Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396608102> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2396608102 endingPage "403" @default.
- W2396608102 startingPage "399" @default.
- W2396608102 abstract "To investigate the effect of siRNA targeting Livin and Survivin gene simultaneously on the proliferation and apoptosis of human colon cancer cells.SiRNA recombinant expression vectors targeting Livin and Survivin gene simultaneously were constructed and transfected into human colon cancer cell line Lovo. The effects of siRNA recombinant expression vector on Lovo cells were detected by RT-PCR, Western blot, MTT reduction assay and flow cytometry.It was confirmed by restriction endonuclease and sequence analysis that siRNA recombinant expression vector targeting Livin and Survivin gene simultaneously was constructed successfully. The suppressive rates of siRNA targeting Livin and Survivin gene simultaneously on Livin mRNA and protein expression were 27.9% and 22.3% respectively, and those on Survivin mRNA and protein expression were 32.2% and 40.9% respectively. The survival rate of cancer cells was decreased whereas the apoptotic rate was increased, but the coordinate repression was weaker than Livin and Survivin RNA interference alone.siRNA targeting Livin and Survivin gene simultaneously can decrease the expression of Livin and Survivin gene, suppress cell proliferation and induce cell apoptosis in human colon cancer. The coordinate repression was weaker than Livin and Survivin RNA interference alone." @default.
- W2396608102 created "2016-06-24" @default.
- W2396608102 creator A5043966557 @default.
- W2396608102 creator A5067612393 @default.
- W2396608102 creator A5079375938 @default.
- W2396608102 creator A5084930619 @default.
- W2396608102 date "2009-07-01" @default.
- W2396608102 modified "2023-09-25" @default.
- W2396608102 title "[Apoptosis induction effect of siRNA recombinant expression vector targeting Livin and Survivin gene simultaneously on human colon cancer cells]." @default.
- W2396608102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19598029" @default.
- W2396608102 hasPublicationYear "2009" @default.
- W2396608102 type Work @default.
- W2396608102 sameAs 2396608102 @default.
- W2396608102 citedByCount "1" @default.
- W2396608102 countsByYear W23966081022016 @default.
- W2396608102 crossrefType "journal-article" @default.
- W2396608102 hasAuthorship W2396608102A5043966557 @default.
- W2396608102 hasAuthorship W2396608102A5067612393 @default.
- W2396608102 hasAuthorship W2396608102A5079375938 @default.
- W2396608102 hasAuthorship W2396608102A5084930619 @default.
- W2396608102 hasConcept C104317684 @default.
- W2396608102 hasConcept C150194340 @default.
- W2396608102 hasConcept C153911025 @default.
- W2396608102 hasConcept C166703698 @default.
- W2396608102 hasConcept C190283241 @default.
- W2396608102 hasConcept C22615655 @default.
- W2396608102 hasConcept C2775975398 @default.
- W2396608102 hasConcept C2776415932 @default.
- W2396608102 hasConcept C2777408456 @default.
- W2396608102 hasConcept C31573885 @default.
- W2396608102 hasConcept C502942594 @default.
- W2396608102 hasConcept C54009773 @default.
- W2396608102 hasConcept C54355233 @default.
- W2396608102 hasConcept C62112901 @default.
- W2396608102 hasConcept C67705224 @default.
- W2396608102 hasConcept C71924100 @default.
- W2396608102 hasConcept C86803240 @default.
- W2396608102 hasConceptScore W2396608102C104317684 @default.
- W2396608102 hasConceptScore W2396608102C150194340 @default.
- W2396608102 hasConceptScore W2396608102C153911025 @default.
- W2396608102 hasConceptScore W2396608102C166703698 @default.
- W2396608102 hasConceptScore W2396608102C190283241 @default.
- W2396608102 hasConceptScore W2396608102C22615655 @default.
- W2396608102 hasConceptScore W2396608102C2775975398 @default.
- W2396608102 hasConceptScore W2396608102C2776415932 @default.
- W2396608102 hasConceptScore W2396608102C2777408456 @default.
- W2396608102 hasConceptScore W2396608102C31573885 @default.
- W2396608102 hasConceptScore W2396608102C502942594 @default.
- W2396608102 hasConceptScore W2396608102C54009773 @default.
- W2396608102 hasConceptScore W2396608102C54355233 @default.
- W2396608102 hasConceptScore W2396608102C62112901 @default.
- W2396608102 hasConceptScore W2396608102C67705224 @default.
- W2396608102 hasConceptScore W2396608102C71924100 @default.
- W2396608102 hasConceptScore W2396608102C86803240 @default.
- W2396608102 hasIssue "4" @default.
- W2396608102 hasLocation W23966081021 @default.
- W2396608102 hasOpenAccess W2396608102 @default.
- W2396608102 hasPrimaryLocation W23966081021 @default.
- W2396608102 hasRelatedWork W1533067014 @default.
- W2396608102 hasRelatedWork W1968362551 @default.
- W2396608102 hasRelatedWork W2109592876 @default.
- W2396608102 hasRelatedWork W2184011015 @default.
- W2396608102 hasRelatedWork W2186171145 @default.
- W2396608102 hasRelatedWork W2363842453 @default.
- W2396608102 hasRelatedWork W2365338112 @default.
- W2396608102 hasRelatedWork W2370235276 @default.
- W2396608102 hasRelatedWork W2370935812 @default.
- W2396608102 hasRelatedWork W2378508402 @default.
- W2396608102 hasRelatedWork W2385778052 @default.
- W2396608102 hasRelatedWork W2389766655 @default.
- W2396608102 hasRelatedWork W2407440884 @default.
- W2396608102 hasRelatedWork W2410133489 @default.
- W2396608102 hasRelatedWork W2736943847 @default.
- W2396608102 hasRelatedWork W2747826012 @default.
- W2396608102 hasRelatedWork W2755801580 @default.
- W2396608102 hasRelatedWork W3028718161 @default.
- W2396608102 hasRelatedWork W3028907841 @default.
- W2396608102 hasRelatedWork W3032832913 @default.
- W2396608102 hasVolume "12" @default.
- W2396608102 isParatext "false" @default.
- W2396608102 isRetracted "false" @default.
- W2396608102 magId "2396608102" @default.
- W2396608102 workType "article" @default.