FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396690909> ?p ?o ?g. }

• W2396690909 endingPage "81" @default.
• W2396690909 startingPage "373" @default.
• W2396690909 abstract "To observe the effect of tert-butylhydroquinone (tBHQ) on the islets function and expression of HO-1 and VEGF in retina of type 2 diabetic rats.Experimental study. Forty healthy male Sprague-Dawley rats with 6 weeks old were given high-fat and high-sugar diet for 4 weeks and then intraperitoneal injection with streptozotocin(STZ) 30mg/kg to induce diabetic model. Model group were further randomly divided into normal group and model group. Ten age matched health rats were chosen as control group. 4 and 12 weeks later, weight of rats , fasting blood glucose (FBG), fasting serum insulin (FINS), the levels of serum liqids were measured. The HO-1 and vascular endothelial growth factor (VEGF) expression in retina were determined by immunohistochmistry and quantitative real-time PCR. The differences of the mean values among the three groups were analyzed by one-factor analysis of variance. The multiple comparisons of the mean values among the three groups were analyzed by LSD-t analysis.Type 2 diabetic model was successfully established in 32 rats, the success rate was 80.0%. Compared with normal gourp, plasma triglyceride (TG), plasma total cholesterol (TC) and plasma low density lipoprotein (LDL-C) of diabetic rats increased dramatically, and plasma high density lipoprotein (HDL-C) decreased. FBG was significant different between all groups(χ(2)4w=10.631, P4W=0.005; χ(2)12w=15.053, P12w=0.001), and was significantly increased in tBHQ intervention group than that in diabetic group at the end of 12 week. The levels of FINS and homeostasis model assessment for insulin resistance (HOMA-IR) were significantly higher , and insulin sensitivity index (ISI) was significantly lower in diabetic and tBHQ intervention group compared with normal group(P<0.05), but there is no significantly difference between diabetic and tBHQ intervention group(P>0.05). The immunohistochemistry staining results showed the protein leveI of retinal HO-1 (F4w=689.535, P4w=0.000; F12w=287.988, P12w=0.000)and VEGF(F4w=1084.956, P4w=0.000; F12w= 1107.553, P12w=0.000) was significant different beteween all groups. The expression of HO-1 mRNA increased significantly in diabetic group(t4w=10.21, t12w=9.95)and tBHQ intervention group(t4w=14.01, t12w= 25.64)than that in normal group(P<0.05). The expression of HO-1 mRNA increased significantly in tBHQ intervention group(t4w=6.04, t12w=19.00)than that in diabetic group(P<0.05). The expression of VEGF mRNA increased significantly in diabetic group(t4w=11.92, t12w=29.27)and tBHQ intervention group(t4w=12.50, t12w= 11.24)than that in normal group(P<0.05). The expression of VEGF mRNA increased significantly in tBHQ intervention group(t4w=-6.36, t12w=-20.22)than that in diabetic group(P<0.05).tBHQ can promote the secretion of insulin in diabetic rats, lowered glucose levels, also induce the expression of HO-1 and suppress the expression of VEGF in retina to confer protection to islets function and retina of type 2 diabtic rats." @default.
• W2396690909 created "2016-06-24" @default.
• W2396690909 creator A5026066949 @default.
• W2396690909 creator A5038096051 @default.
• W2396690909 creator A5075938969 @default.
• W2396690909 creator A5077204221 @default.
• W2396690909 creator A5077744989 @default.
• W2396690909 creator A5087677226 @default.
• W2396690909 date "2016-05-01" @default.
• W2396690909 modified "2023-09-23" @default.
• W2396690909 title "[Influence of tert-butylhydroquinone on the islets function and expression of HO-1 and VEGF in retina of type 2 diabetic rats]." @default.
• W2396690909 doi "https://doi.org/10.3760/cma.j.issn.0412-4081.2016.05.012" @default.
• W2396690909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27220712" @default.
• W2396690909 hasPublicationYear "2016" @default.
• W2396690909 type Work @default.
• W2396690909 sameAs 2396690909 @default.
• W2396690909 citedByCount "0" @default.
• W2396690909 crossrefType "journal-article" @default.
• W2396690909 hasAuthorship W2396690909A5026066949 @default.
• W2396690909 hasAuthorship W2396690909A5038096051 @default.
• W2396690909 hasAuthorship W2396690909A5075938969 @default.
• W2396690909 hasAuthorship W2396690909A5077204221 @default.
• W2396690909 hasAuthorship W2396690909A5077744989 @default.
• W2396690909 hasAuthorship W2396690909A5087677226 @default.
• W2396690909 hasConcept C126322002 @default.
• W2396690909 hasConcept C134018914 @default.
• W2396690909 hasConcept C165220095 @default.
• W2396690909 hasConcept C167734588 @default.
• W2396690909 hasConcept C185592680 @default.
• W2396690909 hasConcept C2777025900 @default.
• W2396690909 hasConcept C2778163477 @default.
• W2396690909 hasConcept C2778913445 @default.
• W2396690909 hasConcept C2779280383 @default.
• W2396690909 hasConcept C2779306644 @default.
• W2396690909 hasConcept C2779829184 @default.
• W2396690909 hasConcept C2780159080 @default.
• W2396690909 hasConcept C2780541478 @default.
• W2396690909 hasConcept C555293320 @default.
• W2396690909 hasConcept C71924100 @default.
• W2396690909 hasConceptScore W2396690909C126322002 @default.
• W2396690909 hasConceptScore W2396690909C134018914 @default.
• W2396690909 hasConceptScore W2396690909C165220095 @default.
• W2396690909 hasConceptScore W2396690909C167734588 @default.
• W2396690909 hasConceptScore W2396690909C185592680 @default.
• W2396690909 hasConceptScore W2396690909C2777025900 @default.
• W2396690909 hasConceptScore W2396690909C2778163477 @default.
• W2396690909 hasConceptScore W2396690909C2778913445 @default.
• W2396690909 hasConceptScore W2396690909C2779280383 @default.
• W2396690909 hasConceptScore W2396690909C2779306644 @default.
• W2396690909 hasConceptScore W2396690909C2779829184 @default.
• W2396690909 hasConceptScore W2396690909C2780159080 @default.
• W2396690909 hasConceptScore W2396690909C2780541478 @default.
• W2396690909 hasConceptScore W2396690909C555293320 @default.
• W2396690909 hasConceptScore W2396690909C71924100 @default.
• W2396690909 hasIssue "5" @default.
• W2396690909 hasLocation W23966909091 @default.
• W2396690909 hasOpenAccess W2396690909 @default.
• W2396690909 hasPrimaryLocation W23966909091 @default.
• W2396690909 hasRelatedWork W1931016857 @default.
• W2396690909 hasRelatedWork W1976841804 @default.
• W2396690909 hasRelatedWork W2003485540 @default.
• W2396690909 hasRelatedWork W2007186002 @default.
• W2396690909 hasRelatedWork W2056069628 @default.
• W2396690909 hasRelatedWork W2070290955 @default.
• W2396690909 hasRelatedWork W2112457773 @default.
• W2396690909 hasRelatedWork W2131147582 @default.
• W2396690909 hasRelatedWork W2397535441 @default.
• W2396690909 hasRelatedWork W2434287781 @default.
• W2396690909 hasVolume "52" @default.
• W2396690909 isParatext "false" @default.
• W2396690909 isRetracted "false" @default.
• W2396690909 magId "2396690909" @default.
• W2396690909 workType "article" @default.