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- W2396715050 abstract "Cells isolated from the uterus of the guinea pig foetus can be maintained in culture even through several sub-cultures. In these cells, estradiol increases progesterone receptor concentrations 2 o 3 times, although estradiol has no effect on cell proliferation. Epidermal growth factor (EGF) stimulates both cell proliferation and the progesterone receptor 4-Hydroxytamoxifen, a tamoxifen metabolite and potent anti-oestrogen, completely inhibits the stimulatory effect of EGF on the progesterone receptor but has no effect on the EGF-induced cell growth. These cells have specific binding sites with high affinity for 125I-EGF. Estradiol increases the number of binding sites but does not affect the affinity for EGF. 4-Hydroxytamoxifen has no significant effect on either the number of binding sites or the binding affinity. In conclusion, EGF could be an autocrine or paracrine factor in estrogen-sensitive cells not only as a potent mitogen but also as a factor capable of increasing an estrogen-induced protein like the progesterone receptor. The observation that an anti-estrogen can also act as an anti-growth factor suggests a close relationship between estrogens and growth factors." @default.
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- W2396715050 date "1989-09-01" @default.
- W2396715050 modified "2023-09-25" @default.
- W2396715050 title "[Epidermal growth factor induces the progesterone receptor in fetal uterine cells in culture: antagonistic effect of antiestrogens]." @default.
- W2396715050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2631032" @default.
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