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- W2396773135 abstract "SummaryTwenty patients (males) with pulmonary surinfection on bronchitis or silicosis are included in this Prospective and controlled trial. Ten patients paired for age, weight and serum creatinine receive either Gentamicin or Tobramycin at similar maintenance dosage during ten consecutive days. The increase of serum creatinine after ten days of treatment is respectively of 12.4 ± 6.2 μ mole/1 (SD) Under Tobramycin and 44.2 ± 37.1 β mole/I Under Gentamicin (p<0.05). Urinary excretion of two tubular enzymes: N-acetyl-β-D-glucosaminidase and Alanine Amino Peptidase increases significantly and correlatedly (p<0.001 r = 0.89) from the first days of treatment in all patients, with however, large individual variations.Therefore, no significant difference between the two groups is found at each stage of therapy.In six patients receiving Tobramycin, urinary excretion of beta 2 microglobulin increases significantly from the fifth day although the threshold serum value for this protein is not reached.Our data suggest a simultaneous and precocious toxic injury of the lysosomes and of the brush border membranes of the proximal tubules, in all patients treated with Tobramycin or Gentamicin.The increase of urinary beta 2 microglobulin under Tobramycin seems explicable either by a competition with aminoglycoside in tubular uptake or t>y a proximal tubular cell dysfunction." @default.
- W2396773135 created "2016-06-24" @default.
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- W2396773135 date "1982-01-01" @default.
- W2396773135 modified "2023-09-23" @default.
- W2396773135 title "Effects of Aminoglycosides on Enzymuria and Beta 2 Microglobulinuria" @default.
- W2396773135 doi "https://doi.org/10.1080/22953337.1982.11718835" @default.
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