Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396784829> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2396784829 endingPage "8" @default.
- W2396784829 startingPage "35" @default.
- W2396784829 abstract "Despite the critical role of the liver in the metabolism of cyclosporine, only a few studies have measured hepatic levels (CSAH) in patients receiving the drug, and none has directly assayed hepatic levels of the metabolites. In this study we measured CSAH and its principal metabolites (mono-OH and di-OH CSA) by HPLC/mass spectroscopy in 19 liver biopsy specimens collected from 14 patients who had undergone liver transplantation, in order to determine how they correlated with blood levels (CSAB). The hepatic concentrations were also compared with biochemical and histological parameters of cholestasis. A positive correlation was observed between CSAH and CSAB (r = 0.47), irrespective of the length of time the patients had received the drug (7 to 1662 days) as defined by the relationship: CSAH(ng/g wet weight) = 6.7 x CSAB(ng/ml)+338. Hepatic levels of metabolites exceeded those of the parent compound in 11 biopsy specimens. No correlation was found for CSAH and the metabolites and serum bilirubin or the degree of cholestasis in the liver biopsy specimens. These findings indicate that: (1) CSA is concentrated in liver tissue several-fold over blood; (2) The hepatic concentration can be estimated from the blood concentration even in the presence of cholestasis; (3) Significant levels of CSA metabolites are found in liver tissue, frequently exceeding the concentration of the parent compound." @default.
- W2396784829 created "2016-06-24" @default.
- W2396784829 creator A5013504895 @default.
- W2396784829 creator A5032452616 @default.
- W2396784829 creator A5035351729 @default.
- W2396784829 creator A5060532902 @default.
- W2396784829 creator A5074727093 @default.
- W2396784829 date "1995-02-01" @default.
- W2396784829 modified "2023-09-23" @default.
- W2396784829 title "Hepatic levels of cyclosporine and metabolites in patients after liver transplantation." @default.
- W2396784829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7742581" @default.
- W2396784829 hasPublicationYear "1995" @default.
- W2396784829 type Work @default.
- W2396784829 sameAs 2396784829 @default.
- W2396784829 citedByCount "2" @default.
- W2396784829 crossrefType "journal-article" @default.
- W2396784829 hasAuthorship W2396784829A5013504895 @default.
- W2396784829 hasAuthorship W2396784829A5032452616 @default.
- W2396784829 hasAuthorship W2396784829A5035351729 @default.
- W2396784829 hasAuthorship W2396784829A5060532902 @default.
- W2396784829 hasAuthorship W2396784829A5074727093 @default.
- W2396784829 hasConcept C126322002 @default.
- W2396784829 hasConcept C142724271 @default.
- W2396784829 hasConcept C2775934546 @default.
- W2396784829 hasConcept C2777477808 @default.
- W2396784829 hasConcept C2777513400 @default.
- W2396784829 hasConcept C2777766500 @default.
- W2396784829 hasConcept C2778593092 @default.
- W2396784829 hasConcept C2779609443 @default.
- W2396784829 hasConcept C2911091166 @default.
- W2396784829 hasConcept C62231903 @default.
- W2396784829 hasConcept C71924100 @default.
- W2396784829 hasConcept C89311334 @default.
- W2396784829 hasConcept C90924648 @default.
- W2396784829 hasConceptScore W2396784829C126322002 @default.
- W2396784829 hasConceptScore W2396784829C142724271 @default.
- W2396784829 hasConceptScore W2396784829C2775934546 @default.
- W2396784829 hasConceptScore W2396784829C2777477808 @default.
- W2396784829 hasConceptScore W2396784829C2777513400 @default.
- W2396784829 hasConceptScore W2396784829C2777766500 @default.
- W2396784829 hasConceptScore W2396784829C2778593092 @default.
- W2396784829 hasConceptScore W2396784829C2779609443 @default.
- W2396784829 hasConceptScore W2396784829C2911091166 @default.
- W2396784829 hasConceptScore W2396784829C62231903 @default.
- W2396784829 hasConceptScore W2396784829C71924100 @default.
- W2396784829 hasConceptScore W2396784829C89311334 @default.
- W2396784829 hasConceptScore W2396784829C90924648 @default.
- W2396784829 hasIssue "1" @default.
- W2396784829 hasLocation W23967848291 @default.
- W2396784829 hasOpenAccess W2396784829 @default.
- W2396784829 hasPrimaryLocation W23967848291 @default.
- W2396784829 hasRelatedWork W2017218231 @default.
- W2396784829 hasRelatedWork W2030892157 @default.
- W2396784829 hasRelatedWork W2341507905 @default.
- W2396784829 hasRelatedWork W2363992619 @default.
- W2396784829 hasRelatedWork W2365705143 @default.
- W2396784829 hasRelatedWork W2379136534 @default.
- W2396784829 hasRelatedWork W2396784829 @default.
- W2396784829 hasRelatedWork W2603936203 @default.
- W2396784829 hasRelatedWork W3039346205 @default.
- W2396784829 hasRelatedWork W51976641 @default.
- W2396784829 hasVolume "9" @default.
- W2396784829 isParatext "false" @default.
- W2396784829 isRetracted "false" @default.
- W2396784829 magId "2396784829" @default.
- W2396784829 workType "article" @default.