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- W2396804766 abstract "Aim: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po 2) in lymphocyte. Methods: Primarily cultured rat splenic lymphocytes were treated with different pressure-duration of oxygen that led to promotion or inhibition of cell function. The catalytic activities, protein expression and tyrosine phosphorylation of SHP-1 and CD45 were determined. Results: The activity of SHP-1 was decreased after high Po 2 treatment no matter what pressure-duration was, while the activity of CD45 was decreased only after high Po 2 that led to inhibition of lymphocyte function. The proteins expressed and tyrosine phosphorylation levels of two enzymes had no alteration in most treatment groups. Conclusion: The decrease of PTP catalytic activities might be caused by their structures modification by high Po 2 induced reactive oxygen species. SHP-1 and CD45 might be one of the key points of action through which high Po 2 exerts its effects on lymphocytes." @default.
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- W2396804766 date "2005-02-01" @default.
- W2396804766 modified "2023-09-29" @default.
- W2396804766 title "[The state of SHP-1 and CD45 in lymphocyte under high partial pressure of oxygen]." @default.
- W2396804766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21166153" @default.
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