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• W2396811662 endingPage "2104" @default.
• W2396811662 startingPage "2089" @default.
• W2396811662 abstract "Glucose and oxygen are two of the most important molecules transferred from mother to fetus during eutherian pregnancy, and the metabolic fates of these nutrients converge at the transport and metabolism of pyruvate in mitochondria. Pyruvate enters the mitochondrial matrix through the mitochondrial pyruvate carrier (MPC), a complex in the inner mitochondrial membrane that consists of two essential components, MPC1 and MPC2. Here, we define the requirement for mitochondrial pyruvate metabolism during development with a progressive allelic series of Mpc1 deficiency in mouse. Mpc1 deletion was homozygous lethal in midgestation, but Mpc1 hypomorphs and tissue-specific deletion of Mpc1 presented as early perinatal lethality. The allelic series demonstrated that graded suppression of MPC resulted in dose-dependent metabolic and transcriptional changes. Steady-state metabolomics analysis of brain and liver from Mpc1 hypomorphic embryos identified compensatory changes in amino acid and lipid metabolism. Flux assays in Mpc1-deficient embryonic fibroblasts also reflected these changes, including a dramatic increase in mitochondrial alanine utilization. The mitochondrial alanine transaminase GPT2 was found to be necessary and sufficient for increased alanine flux upon MPC inhibition. These data show that impaired mitochondrial pyruvate transport results in biosynthetic deficiencies that can be mitigated in part by alternative anaplerotic substrates in utero." @default.
• W2396811662 created "2016-06-24" @default.
• W2396811662 creator A5043042092 @default.
• W2396811662 creator A5050365273 @default.
• W2396811662 creator A5071347274 @default.
• W2396811662 creator A5091124551 @default.
• W2396811662 date "2016-08-01" @default.
• W2396811662 modified "2023-10-15" @default.
• W2396811662 title "Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series" @default.
• W2396811662 cites W1559676886 @default.
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• W2396811662 cites W1811725048 @default.
• W2396811662 cites W1879352431 @default.
• W2396811662 cites W1900054156 @default.
• W2396811662 cites W1921406091 @default.
• W2396811662 cites W1932780354 @default.
• W2396811662 cites W1932854961 @default.
• W2396811662 cites W1949786344 @default.
• W2396811662 cites W1960148369 @default.
• W2396811662 cites W1968363533 @default.
• W2396811662 cites W1973113504 @default.
• W2396811662 cites W1982330633 @default.
• W2396811662 cites W1986991123 @default.
• W2396811662 cites W1989520029 @default.
• W2396811662 cites W1991290396 @default.
• W2396811662 cites W1991648436 @default.
• W2396811662 cites W1999333889 @default.
• W2396811662 cites W2003171404 @default.
• W2396811662 cites W2013334588 @default.
• W2396811662 cites W2014058353 @default.
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• W2396811662 cites W2047911553 @default.
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• W2396811662 doi "https://doi.org/10.1128/mcb.00166-16" @default.
• W2396811662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4946427" @default.
• W2396811662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27215380" @default.
• W2396811662 hasPublicationYear "2016" @default.
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