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• W2396908022 abstract "B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen internalization in immune synapses. Using large-scale imaging across B cell subsets, we found that, in contrast with naive and memory B cells, which gathered antigen toward the synapse center before internalization, germinal center (GC) B cells extracted antigen by a distinct pathway using small peripheral clusters. Both naive and GC B cell synapses required proximal BCR signaling, but GC cells signaled less through the protein kinase C-β-NF-κB pathway and produced stronger tugging forces on the BCR, thereby more stringently regulating antigen binding. Consequently, GC B cells extracted antigen with better affinity discrimination than naive B cells, suggesting that specialized biomechanical patterns in B cell synapses regulate T cell-dependent selection of high-affinity B cells in GCs." @default.
• W2396908022 created "2016-06-24" @default.
• W2396908022 creator A5001294774 @default.
• W2396908022 creator A5056278119 @default.
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• W2396908022 date "2016-05-16" @default.
• W2396908022 modified "2023-10-10" @default.
• W2396908022 title "Germinal center B cells recognize antigen through a specialized immune synapse architecture" @default.
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• W2396908022 doi "https://doi.org/10.1038/ni.3458" @default.
• W2396908022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4943528" @default.
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