Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396973143> ?p ?o ?g. }
- W2396973143 endingPage "2265" @default.
- W2396973143 startingPage "2251" @default.
- W2396973143 abstract "Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas perturbations to Denr impair the long-term positioning, dendritic arborization, and dendritic spine characteristics of postnatal projection neurons. We characterized de novo missense mutations in DENR (p.C37Y and p.P121L) detected in two unrelated human subjects diagnosed with brain developmental disorder to find that each variant impairs the function of DENR in mRNA translation re-initiation and disrupts the migration and terminal branching of cortical neurons in different ways. Thus, our findings link human brain disorders to impaired mRNA translation re-initiation through perturbations in DENR (OMIM: 604550) function in neurons." @default.
- W2396973143 created "2016-06-24" @default.
- W2396973143 creator A5007519527 @default.
- W2396973143 creator A5011356431 @default.
- W2396973143 creator A5017810366 @default.
- W2396973143 creator A5021944265 @default.
- W2396973143 creator A5044661699 @default.
- W2396973143 creator A5049182473 @default.
- W2396973143 creator A5050030530 @default.
- W2396973143 creator A5050778277 @default.
- W2396973143 creator A5052778454 @default.
- W2396973143 creator A5052845737 @default.
- W2396973143 creator A5056809474 @default.
- W2396973143 creator A5061323937 @default.
- W2396973143 creator A5061706996 @default.
- W2396973143 creator A5062455516 @default.
- W2396973143 creator A5070688637 @default.
- W2396973143 creator A5082259407 @default.
- W2396973143 creator A5089485574 @default.
- W2396973143 date "2016-06-01" @default.
- W2396973143 modified "2023-10-16" @default.
- W2396973143 title "De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation" @default.
- W2396973143 cites W1965456948 @default.
- W2396973143 cites W1966992478 @default.
- W2396973143 cites W1981379485 @default.
- W2396973143 cites W1986223165 @default.
- W2396973143 cites W1996905285 @default.
- W2396973143 cites W1999794337 @default.
- W2396973143 cites W1999841014 @default.
- W2396973143 cites W2008235053 @default.
- W2396973143 cites W2009865652 @default.
- W2396973143 cites W2011209444 @default.
- W2396973143 cites W2014766025 @default.
- W2396973143 cites W2024663595 @default.
- W2396973143 cites W2025603247 @default.
- W2396973143 cites W2036581163 @default.
- W2396973143 cites W2044531433 @default.
- W2396973143 cites W2046683077 @default.
- W2396973143 cites W2047452007 @default.
- W2396973143 cites W2047690919 @default.
- W2396973143 cites W2060965924 @default.
- W2396973143 cites W2061868267 @default.
- W2396973143 cites W2089242029 @default.
- W2396973143 cites W2093225683 @default.
- W2396973143 cites W2095664656 @default.
- W2396973143 cites W2095711264 @default.
- W2396973143 cites W2099378585 @default.
- W2396973143 cites W2100517566 @default.
- W2396973143 cites W2101693384 @default.
- W2396973143 cites W2103059305 @default.
- W2396973143 cites W2114611110 @default.
- W2396973143 cites W2117767933 @default.
- W2396973143 cites W2121305410 @default.
- W2396973143 cites W2127220436 @default.
- W2396973143 cites W2133212095 @default.
- W2396973143 cites W2136015426 @default.
- W2396973143 cites W2138304538 @default.
- W2396973143 cites W2141838466 @default.
- W2396973143 cites W2142438562 @default.
- W2396973143 cites W2142517432 @default.
- W2396973143 cites W2142680666 @default.
- W2396973143 cites W2142826449 @default.
- W2396973143 cites W2144132729 @default.
- W2396973143 cites W2148400099 @default.
- W2396973143 cites W2154934792 @default.
- W2396973143 cites W2163139716 @default.
- W2396973143 cites W2180986577 @default.
- W2396973143 doi "https://doi.org/10.1016/j.celrep.2016.04.090" @default.
- W2396973143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4906373" @default.
- W2396973143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27239039" @default.
- W2396973143 hasPublicationYear "2016" @default.
- W2396973143 type Work @default.
- W2396973143 sameAs 2396973143 @default.
- W2396973143 citedByCount "26" @default.
- W2396973143 countsByYear W23969731432017 @default.
- W2396973143 countsByYear W23969731432018 @default.
- W2396973143 countsByYear W23969731432019 @default.
- W2396973143 countsByYear W23969731432020 @default.
- W2396973143 countsByYear W23969731432021 @default.
- W2396973143 countsByYear W23969731432022 @default.
- W2396973143 countsByYear W23969731432023 @default.
- W2396973143 crossrefType "journal-article" @default.
- W2396973143 hasAuthorship W2396973143A5007519527 @default.
- W2396973143 hasAuthorship W2396973143A5011356431 @default.
- W2396973143 hasAuthorship W2396973143A5017810366 @default.
- W2396973143 hasAuthorship W2396973143A5021944265 @default.
- W2396973143 hasAuthorship W2396973143A5044661699 @default.
- W2396973143 hasAuthorship W2396973143A5049182473 @default.
- W2396973143 hasAuthorship W2396973143A5050030530 @default.
- W2396973143 hasAuthorship W2396973143A5050778277 @default.
- W2396973143 hasAuthorship W2396973143A5052778454 @default.
- W2396973143 hasAuthorship W2396973143A5052845737 @default.
- W2396973143 hasAuthorship W2396973143A5056809474 @default.
- W2396973143 hasAuthorship W2396973143A5061323937 @default.
- W2396973143 hasAuthorship W2396973143A5061706996 @default.
- W2396973143 hasAuthorship W2396973143A5062455516 @default.
- W2396973143 hasAuthorship W2396973143A5070688637 @default.
- W2396973143 hasAuthorship W2396973143A5082259407 @default.