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- W2396979117 abstract "To study the character of non-selective cation channel in human umbilical cord vein endothelial cell line ECV304 and the effect of tumor necrosis factor-alpha (TNF-alpha) on channel activity.Patch clamp technique was used to record single channel and whole cell currents.This channel can be activated by calcium, channel conductance was (19.74 +/- 2.35) pS and its Po was 0.260 +/- 0.006 (n = 5). 100 U/ml TNF-alpha inhibited channel activity, showing that conductance reduced to (10.69 +/- 4.68) pS and Po reduced to 0.230 +/- 0.051 (n = 5). Results in whole-cell configuration were consistent with that in cell-attached patches. Currents were obviously blocked by Cl- channel inhibitor anthracene-9-carboxylic acid (A9C). In order to testify the character of this channel further, KCl and NaCl were exchanged by K(+)-Aspartate in pipette solution. Under this condition, the single channel activities as before were recorded again. Its conductance was (18.33 +/- 2.98) pS(n = 8), and TNF-alpha as well as A9C could inhibit channel activity. But this channel activity could not be blocked by another Cl- channel blocker Zn2+. In the condition of K-Asparate replaced by CsCl in solution, identical channel activity as before could not be recorded. It seemed that Cs+ could not pass through this cation channel.It is inferred that calcium-activated non-selective-action channel recorded in endothelial cell ECV304, can be inhibited by TNF-alpha and A9C." @default.
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- W2396979117 date "2000-10-01" @default.
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- W2396979117 title "[Calcium activated non-selective cation channel in endothelial cell line ECV304 and inhibition of tumor necrosis factor-alpha]." @default.
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