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• W2396979416 abstract "Jun : Fos and Jun : ATF complexes represent two classes of AP-1 dimers that (1) preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are differently regulated by cellular signaling pathways and oncogene products. To discriminate between the functions of Jun : Fos, Jun : ATF and Jun : Jun, mutants were developed that restrict the ability of Jun to dimerize either to itself, or to Fos(-like) or ATF(-like) partners. Introduction of these mutants in chicken embryo fibroblasts shows that Jun : Fra2 and Jun : ATF2 dimers play distinct, complementary roles in in vitro oncogenesis by inducing either anchorage independence or growth factor independence, respectively. v-Jun : ATF2 rather than v-Jun : Fra2 triggers the development of primary fibrosarcomas in the chicken wing. Genes encoding extracellular matrix components seem to constitute an important subset of v-Jun : ATF2-target genes. Repression of the matrix component SPARC by Jun is essential for the induction of fibrosarcomas. Avian primary cells transformed by either Jun : Fra2 or Jun : ATF2 thus provide powerful tools for the investigation of the downstream pathways involved in oncogenesis. Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems." @default.
• W2396979416 created "2016-06-24" @default.
• W2396979416 creator A5005618621 @default.
• W2396979416 creator A5015796005 @default.
• W2396979416 date "2001-04-30" @default.
• W2396979416 modified "2023-10-17" @default.
• W2396979416 title "Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis" @default.
• W2396979416 cites W146861865 @default.
• W2396979416 cites W1516457342 @default.
• W2396979416 cites W1521237417 @default.
• W2396979416 cites W1555489233 @default.
• W2396979416 cites W1598659248 @default.
• W2396979416 cites W1603478517 @default.
• W2396979416 cites W1692197226 @default.
• W2396979416 cites W1845978309 @default.
• W2396979416 cites W1847275787 @default.
• W2396979416 cites W1888588308 @default.
• W2396979416 cites W1895834181 @default.
• W2396979416 cites W1927565545 @default.
• W2396979416 cites W1963547997 @default.
• W2396979416 cites W1968062627 @default.
• W2396979416 cites W1969071487 @default.
• W2396979416 cites W1969281472 @default.
• W2396979416 cites W1970058540 @default.
• W2396979416 cites W1970133781 @default.
• W2396979416 cites W1972823584 @default.
• W2396979416 cites W1973919009 @default.
• W2396979416 cites W1979655386 @default.
• W2396979416 cites W1981023964 @default.
• W2396979416 cites W1986157687 @default.
• W2396979416 cites W1987453246 @default.
• W2396979416 cites W1993983676 @default.
• W2396979416 cites W1994975139 @default.
• W2396979416 cites W1998130451 @default.
• W2396979416 cites W2002630364 @default.
• W2396979416 cites W2006945872 @default.
• W2396979416 cites W2007468038 @default.
• W2396979416 cites W2011827225 @default.
• W2396979416 cites W2012318656 @default.
• W2396979416 cites W2016774526 @default.
• W2396979416 cites W2023666553 @default.
• W2396979416 cites W2026181894 @default.
• W2396979416 cites W2034269086 @default.
• W2396979416 cites W2035209826 @default.
• W2396979416 cites W2036046756 @default.
• W2396979416 cites W2036224418 @default.
• W2396979416 cites W2036692598 @default.
• W2396979416 cites W2042260090 @default.
• W2396979416 cites W2044987829 @default.
• W2396979416 cites W2045610791 @default.
• W2396979416 cites W2045798063 @default.
• W2396979416 cites W2047285050 @default.
• W2396979416 cites W2052994742 @default.
• W2396979416 cites W2058744360 @default.
• W2396979416 cites W2063746249 @default.
• W2396979416 cites W2064265900 @default.
• W2396979416 cites W2066101080 @default.
• W2396979416 cites W2067837253 @default.
• W2396979416 cites W2075556833 @default.
• W2396979416 cites W2082688528 @default.
• W2396979416 cites W2082961684 @default.
• W2396979416 cites W2085730499 @default.
• W2396979416 cites W2086880360 @default.
• W2396979416 cites W2089256610 @default.
• W2396979416 cites W2093673282 @default.
• W2396979416 cites W2094807913 @default.
• W2396979416 cites W2094872845 @default.
• W2396979416 cites W2095194341 @default.
• W2396979416 cites W2096866437 @default.
• W2396979416 cites W2109399660 @default.
• W2396979416 cites W2112286041 @default.
• W2396979416 cites W2112468983 @default.
• W2396979416 cites W2113737578 @default.
• W2396979416 cites W2119028299 @default.
• W2396979416 cites W2125677984 @default.
• W2396979416 cites W2139488443 @default.
• W2396979416 cites W2139914947 @default.
• W2396979416 cites W2140582490 @default.
• W2396979416 cites W2142182363 @default.
• W2396979416 cites W2144517045 @default.
• W2396979416 cites W2147084019 @default.
• W2396979416 cites W2150498320 @default.
• W2396979416 cites W2159335638 @default.
• W2396979416 cites W2159390753 @default.
• W2396979416 cites W2159922011 @default.
• W2396979416 cites W2160767270 @default.
• W2396979416 cites W2162609478 @default.
• W2396979416 cites W2167978536 @default.
• W2396979416 cites W2313750402 @default.
• W2396979416 cites W2321348439 @default.
• W2396979416 cites W2324347911 @default.
• W2396979416 cites W2325610284 @default.
• W2396979416 cites W2326990516 @default.
• W2396979416 cites W2328064496 @default.
• W2396979416 cites W2329930272 @default.
• W2396979416 cites W2331602964 @default.
• W2396979416 cites W2332064520 @default.
• W2396979416 cites W2333033610 @default.

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