Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397029126> ?p ?o ?g. }
- W2397029126 endingPage "1040" @default.
- W2397029126 startingPage "1033" @default.
- W2397029126 abstract "Pairing between homologous chromosomes is essential for successful meiosis; generally only paired homologs recombine and segregate correctly into haploid germ cells. Homologs also pair in some somatic cells (e.g. in diploid and polytene cells of Drosophila). How homologs find their partners is a mystery. First, I review some explanations of how they might do so; most involve base-pairing (i.e. DNA-DNA) interactions. Then I discuss the remarkable fact that chromosomes only pair when they are transcriptionally active. Finally, I present a general model for pairing based upon the DNA-protein interactions involved in transcription. Each chromosome in the haploid set has a unique array of transcription units strung along its length. Therefore, each chromatin fibre will be folded into a unique array of loops associated with clusters of polymerases and transcription factors; only homologs share similar arrays. As these loops and clusters, or transcription factories, move continually, they make and break contact with others. Correct pairing would be nucleated when a promoter in a loop tethered to one factory binds to a homologous polymerizing site in another factory, before transcription stabilizes the association. This increases the chances that adjacent promoters will bind to their homologs, so that chromosomes eventually become zipped together with their partners. Pairing is then the inevitable consequence of transcription of partially-condensed chromosomes." @default.
- W2397029126 created "2016-06-24" @default.
- W2397029126 creator A5037053123 @default.
- W2397029126 date "1997-05-01" @default.
- W2397029126 modified "2023-10-17" @default.
- W2397029126 title "The transcriptional basis of chromosome pairing" @default.
- W2397029126 cites W1564476465 @default.
- W2397029126 cites W1877359570 @default.
- W2397029126 cites W1896499191 @default.
- W2397029126 cites W1964059076 @default.
- W2397029126 cites W1968645164 @default.
- W2397029126 cites W1970771773 @default.
- W2397029126 cites W1972877061 @default.
- W2397029126 cites W1973288261 @default.
- W2397029126 cites W1984688123 @default.
- W2397029126 cites W1985218830 @default.
- W2397029126 cites W1986590336 @default.
- W2397029126 cites W1986730363 @default.
- W2397029126 cites W1994776594 @default.
- W2397029126 cites W1999718358 @default.
- W2397029126 cites W2001155934 @default.
- W2397029126 cites W2010058099 @default.
- W2397029126 cites W2022123138 @default.
- W2397029126 cites W2022865656 @default.
- W2397029126 cites W2023510408 @default.
- W2397029126 cites W2032297400 @default.
- W2397029126 cites W2034252391 @default.
- W2397029126 cites W2035756674 @default.
- W2397029126 cites W2039284752 @default.
- W2397029126 cites W2039438812 @default.
- W2397029126 cites W2039858277 @default.
- W2397029126 cites W2052968074 @default.
- W2397029126 cites W2056526354 @default.
- W2397029126 cites W2056750443 @default.
- W2397029126 cites W2059221980 @default.
- W2397029126 cites W2059428026 @default.
- W2397029126 cites W2061112864 @default.
- W2397029126 cites W2067356383 @default.
- W2397029126 cites W2068822634 @default.
- W2397029126 cites W2069449012 @default.
- W2397029126 cites W2073313097 @default.
- W2397029126 cites W2073722866 @default.
- W2397029126 cites W2073882445 @default.
- W2397029126 cites W2075803846 @default.
- W2397029126 cites W2077297124 @default.
- W2397029126 cites W2077751434 @default.
- W2397029126 cites W2080615813 @default.
- W2397029126 cites W2080818512 @default.
- W2397029126 cites W2083972154 @default.
- W2397029126 cites W2084748926 @default.
- W2397029126 cites W2092097845 @default.
- W2397029126 cites W2094414993 @default.
- W2397029126 cites W2101588034 @default.
- W2397029126 cites W2104603726 @default.
- W2397029126 cites W2107746480 @default.
- W2397029126 cites W2109584264 @default.
- W2397029126 cites W2115512131 @default.
- W2397029126 cites W2118834362 @default.
- W2397029126 cites W2119106904 @default.
- W2397029126 cites W2123005075 @default.
- W2397029126 cites W2130226882 @default.
- W2397029126 cites W2143396816 @default.
- W2397029126 cites W2145557480 @default.
- W2397029126 cites W2146404878 @default.
- W2397029126 cites W2152128037 @default.
- W2397029126 cites W2152251331 @default.
- W2397029126 cites W2159555868 @default.
- W2397029126 cites W2162125655 @default.
- W2397029126 cites W2166252054 @default.
- W2397029126 cites W2169441156 @default.
- W2397029126 cites W2179227716 @default.
- W2397029126 cites W2184334441 @default.
- W2397029126 cites W2188108820 @default.
- W2397029126 cites W2194804006 @default.
- W2397029126 cites W2885822705 @default.
- W2397029126 cites W4233570200 @default.
- W2397029126 cites W4251663987 @default.
- W2397029126 doi "https://doi.org/10.1242/jcs.110.9.1033" @default.
- W2397029126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9175699" @default.
- W2397029126 hasPublicationYear "1997" @default.
- W2397029126 type Work @default.
- W2397029126 sameAs 2397029126 @default.
- W2397029126 citedByCount "89" @default.
- W2397029126 countsByYear W23970291262012 @default.
- W2397029126 countsByYear W23970291262013 @default.
- W2397029126 countsByYear W23970291262014 @default.
- W2397029126 countsByYear W23970291262015 @default.
- W2397029126 countsByYear W23970291262016 @default.
- W2397029126 countsByYear W23970291262017 @default.
- W2397029126 countsByYear W23970291262018 @default.
- W2397029126 countsByYear W23970291262019 @default.
- W2397029126 countsByYear W23970291262020 @default.
- W2397029126 countsByYear W23970291262021 @default.
- W2397029126 countsByYear W23970291262022 @default.
- W2397029126 countsByYear W23970291262023 @default.
- W2397029126 crossrefType "journal-article" @default.
- W2397029126 hasAuthorship W2397029126A5037053123 @default.
- W2397029126 hasConcept C104317684 @default.