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• W2397061948 abstract "Clostridium perfringensis the causative agent of clostridial myonecrosis or gas gangrene and mediates infection and disease by producing numerous extracellular toxins, including α-toxin, θ-toxin and κ-toxin Tn916-mutagenesis was used to isolate mutants defective in their ability to produce either α-toxin or θ-toxin. Nine independently derived mutants were isolated In four of these mutants Tn916had inserted at sites located 193 bp or 198 bp upstream of the θ-toxin structural gene,pfoAFour mutants contained large deletions, three in regions which encompassed the θ-toxin structural and regulatory genespfoAandpfoR, respectively, and the κ-toxin structural gene,colA, and one in a region encompassing the α-toxin structural gene,plcThese mutants should prove to be invaluable for further genetic studies aimed at determining the role of these toxins in virulence" @default.
• W2397061948 created "2016-06-24" @default.
• W2397061948 creator A5053064309 @default.
• W2397061948 creator A5053957570 @default.
• W2397061948 date "1997-05-01" @default.
• W2397061948 modified "2023-09-25" @default.
• W2397061948 title "Isolation of α-toxin, θ-toxin and κ-toxin mutants ofClostridium perfringensby Tn916mutagenesis" @default.
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• W2397061948 doi "https://doi.org/10.1006/mpat.1996.0115" @default.
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