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- W2397079377 abstract "Preclinical evidence has been accumulating on the impact of the DNA repair status on the sensitivity/resistance to anticancer agents in different tumor types, including lung cancer. The possibility to predict the response to therapy, and specifically to platinum agents, based on tumor specific DNA repair functionality would enable to tailor its use only in those patients with maximum chances to respond, avoiding the burden of toxicity in those ones with lesser chances. We here reviewed the clinical evidence on the prognostic role of DNA repair markers and/or functional assays in predicting the response to a platinum-based chemotherapy in lung cancer patients. Consequently, we focused on those proteins involved in pathways repairing platinum induced DNA inter-strand and intra-strand crosslinks. Most promising clinical trials targeting the nucleotide repair protein ERCC1 in non-small cell lung cancer later on suffered from serious drawbacks. Nevertheless, these results spurred a variety of preclinical studies on a multitude of alternative DNA repair markers. However so far, no one of the analyzed DNA repair markers can be considered a reliable and mature biomarker for selecting patients. We discuss the reasons for such failure which discloses novel strategies for the future." @default.
- W2397079377 created "2016-06-24" @default.
- W2397079377 creator A5001684767 @default.
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- W2397079377 creator A5047481473 @default.
- W2397079377 creator A5091714925 @default.
- W2397079377 date "2016-07-01" @default.
- W2397079377 modified "2023-10-18" @default.
- W2397079377 title "Can the response to a platinum-based therapy be predicted by the DNA repair status in non-small cell lung cancer?" @default.
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