Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397133057> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2397133057 endingPage "71" @default.
- W2397133057 startingPage "259" @default.
- W2397133057 abstract "We report here that a highly toxic coplanar polychlorinated biphenyl (PCB), 3,3',4,4',5-pentachlorobiphenyl (PenCB) induces molecular chaperones, HSP70 and HSP90 in liver cytosol of rats. Male Wistar rats received PenCB in corn oil once at a dose of 25 mg/kg i.p. Pair-fed control groups were treated with the vehicle and given the amount of chow matched with that taken by the PenCB-treated animals, and free-fed controls were given the vehicle. The liver cytosolic HSP70 level in rats treated with PenCB was 5-fold higher than those in free-fed controls, though that for pair-fed controls was approximately 2-fold higher than that in free-fed controls. The liver cytosolic HSP90 alpha and HSP90 beta levels were also higher in PenCB-treated rats than in both control groups, but the induction extent was lesser than that for HSP70. Inductive effect on the chaperones was examined with a single different dose of PenCB 0, 0.5, 1.0, 5.0, 10 and 25 mg/kg. Marked induction of the HSP70 level was observed with a minimum dose of PenCB 0.5 mg/kg. The HSP90 alpha level was induced with PenCB-dose dependent manner although the HSP90 beta induction was greatest with a dose of PenCB 5.0 mg/kg. HSP70 and HSP90 are essential for cells under normal conditions and act as molecular chaperones. HSP90 is well known to modulate the function of sex steroid hormone or aromatic hydrocarbon receptors while HSP70 is required for receptor-HSP90 heterocomplex assembly. The role of molecular chaperones may be involved in the endocrine disrupting properties of coplanar PCB and dioxins." @default.
- W2397133057 created "2016-06-24" @default.
- W2397133057 creator A5014603664 @default.
- W2397133057 creator A5021405413 @default.
- W2397133057 creator A5033044041 @default.
- W2397133057 creator A5068326959 @default.
- W2397133057 creator A5079992977 @default.
- W2397133057 creator A5091016662 @default.
- W2397133057 date "1999-05-01" @default.
- W2397133057 modified "2023-10-16" @default.
- W2397133057 title "[Induction of molecular chaperones HSP70 and HSP90 in rat liver cytosol by a highly toxic coplanar PCB]." @default.
- W2397133057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10396883" @default.
- W2397133057 hasPublicationYear "1999" @default.
- W2397133057 type Work @default.
- W2397133057 sameAs 2397133057 @default.
- W2397133057 citedByCount "3" @default.
- W2397133057 countsByYear W23971330572019 @default.
- W2397133057 crossrefType "journal-article" @default.
- W2397133057 hasAuthorship W2397133057A5014603664 @default.
- W2397133057 hasAuthorship W2397133057A5021405413 @default.
- W2397133057 hasAuthorship W2397133057A5033044041 @default.
- W2397133057 hasAuthorship W2397133057A5068326959 @default.
- W2397133057 hasAuthorship W2397133057A5079992977 @default.
- W2397133057 hasAuthorship W2397133057A5091016662 @default.
- W2397133057 hasConcept C104317684 @default.
- W2397133057 hasConcept C126322002 @default.
- W2397133057 hasConcept C134018914 @default.
- W2397133057 hasConcept C170493617 @default.
- W2397133057 hasConcept C181199279 @default.
- W2397133057 hasConcept C185592680 @default.
- W2397133057 hasConcept C205260736 @default.
- W2397133057 hasConcept C2775932338 @default.
- W2397133057 hasConcept C55493867 @default.
- W2397133057 hasConcept C68991219 @default.
- W2397133057 hasConcept C71924100 @default.
- W2397133057 hasConcept C86803240 @default.
- W2397133057 hasConcept C98274493 @default.
- W2397133057 hasConcept C98539663 @default.
- W2397133057 hasConceptScore W2397133057C104317684 @default.
- W2397133057 hasConceptScore W2397133057C126322002 @default.
- W2397133057 hasConceptScore W2397133057C134018914 @default.
- W2397133057 hasConceptScore W2397133057C170493617 @default.
- W2397133057 hasConceptScore W2397133057C181199279 @default.
- W2397133057 hasConceptScore W2397133057C185592680 @default.
- W2397133057 hasConceptScore W2397133057C205260736 @default.
- W2397133057 hasConceptScore W2397133057C2775932338 @default.
- W2397133057 hasConceptScore W2397133057C55493867 @default.
- W2397133057 hasConceptScore W2397133057C68991219 @default.
- W2397133057 hasConceptScore W2397133057C71924100 @default.
- W2397133057 hasConceptScore W2397133057C86803240 @default.
- W2397133057 hasConceptScore W2397133057C98274493 @default.
- W2397133057 hasConceptScore W2397133057C98539663 @default.
- W2397133057 hasIssue "5" @default.
- W2397133057 hasLocation W23971330571 @default.
- W2397133057 hasOpenAccess W2397133057 @default.
- W2397133057 hasPrimaryLocation W23971330571 @default.
- W2397133057 hasRelatedWork W1511792975 @default.
- W2397133057 hasRelatedWork W1988702999 @default.
- W2397133057 hasRelatedWork W2002579601 @default.
- W2397133057 hasRelatedWork W2009526355 @default.
- W2397133057 hasRelatedWork W2053335981 @default.
- W2397133057 hasRelatedWork W2064284998 @default.
- W2397133057 hasRelatedWork W2069302954 @default.
- W2397133057 hasRelatedWork W2120573615 @default.
- W2397133057 hasRelatedWork W2171723716 @default.
- W2397133057 hasRelatedWork W2022381224 @default.
- W2397133057 hasVolume "90" @default.
- W2397133057 isParatext "false" @default.
- W2397133057 isRetracted "false" @default.
- W2397133057 magId "2397133057" @default.
- W2397133057 workType "article" @default.