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- W2397145573 abstract "To determine the contents of L-enantiomer impurity in valaciclovir hydrochloride.Valaciclovir enantiomers were separated and determined by using chiral high performance liquid chromatography. Chromatographic conditions were as follows:CROWNPAK(®) CR(+) chiral column (4 mm×150 mm, 5 μm), detection wavelength:254 nm, mobile phase:water-methanol-perchloric acid (19:1:0.1), flow rate:0.75 ml/min, sample injection volume:10 μl.D-valaciclovir was completely separated from L-enantiomer impurity. The contents of L-enantiomer impurity were 0.65%-2.62% on average in 8 batches of valaciclovir hydrochloride.Enantiomeric impurity contents in each batch of products were all meet criteria of United States Pharmacopeia, which can be used in criteria of Chinese Pharmacopeia as references." @default.
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- W2397145573 date "2014-03-01" @default.
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- W2397145573 title "[Enantiomeric separation and impurity determination of valaciclovir hydrochloride]." @default.
- W2397145573 doi "https://doi.org/10.3785/j.issn.1008-9292.2014.03.008" @default.
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