FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397155330> ?p ?o ?g. }

• W2397155330 abstract "Quaking (QKI), which belongs to the STAR family of KH domain-containing RNA-binding proteins, functions in pre-mRNA splicing, microRNA regulation, and formation of circular RNA. QKI plays critical roles in myelinogenesis in the central and peripheral nervous systems and has been implicated neuron-glia fate decision in the brain; however, neither the expression nor function of QKI in the neural retina is known. Here we report the expression of QKI RNA-binding protein in the developing and mature mouse retina. QKI was strongly expressed by Müller glial cells in both the developing and adult retina. Intriguingly, during development, QKI was expressed in early differentiating neurons, such as the horizontal and amacrine cells, and subsequently in later differentiating bipolar cells, but not in photoreceptors. Neuronal expression was uniformly weak in the adult. Among QKI isoforms (5, 6, and 7), QKI-5 was the predominantly expressed isoform in the adult retina. To study the function of QKI in the mouse retina, we examined quakingviable(qkv) mice, which have a dysmyelination phenotype that results from deficiency of QKI expression and reduced numbers of mature oligodendrocytes. In homozygous qkv mutant mice (qkv/qkv), the optic nerve expression levels of QKI-6 and 7, but not QKI-5 were reduced. In the retina of the mutant homozygote, QKI-5 levels were unchanged, and QKI-6 and 7 levels, already low, were also unaffected. We conclude that QKI is expressed in developing and adult Müller glia. QKI is additionally expressed in progenitors and in differentiating neurons during retinal development, but expression weakened or diminished during maturation. Among QKI isoforms, we found that QKI-5 predominated in the adult mouse retina. Since Müller glial cells are thought to share properties with retinal progenitor cells, our data suggest that QKI may contribute to maintaining retinal progenitors prior to differentiation into neurons. On the other hand, the expression of QKI in different retinal neurons may suggest a role in neuronal cell type specific fate determination and maturation. The data raises the possibility that QKI may function in retinal cell fate determination and maturation in both glia and neurons." @default.
• W2397155330 created "2016-06-24" @default.
• W2397155330 creator A5000466178 @default.
• W2397155330 creator A5032162260 @default.
• W2397155330 creator A5058796976 @default.
• W2397155330 creator A5065422122 @default.
• W2397155330 creator A5075465842 @default.
• W2397155330 creator A5076551456 @default.
• W2397155330 creator A5083426647 @default.
• W2397155330 creator A5086588508 @default.
• W2397155330 date "2016-05-19" @default.
• W2397155330 modified "2023-10-14" @default.
• W2397155330 title "Expression of Quaking RNA-Binding Protein in the Adult and Developing Mouse Retina" @default.
• W2397155330 cites W1533487943 @default.
• W2397155330 cites W1895565798 @default.
• W2397155330 cites W1964060243 @default.
• W2397155330 cites W1966557314 @default.
• W2397155330 cites W1970878624 @default.
• W2397155330 cites W1974944966 @default.
• W2397155330 cites W1978174272 @default.
• W2397155330 cites W1989385767 @default.
• W2397155330 cites W1989403911 @default.
• W2397155330 cites W2009990282 @default.
• W2397155330 cites W2011443140 @default.
• W2397155330 cites W2013134059 @default.
• W2397155330 cites W2014403665 @default.
• W2397155330 cites W2015034754 @default.
• W2397155330 cites W2015966587 @default.
• W2397155330 cites W2019343236 @default.
• W2397155330 cites W2023930700 @default.
• W2397155330 cites W2025893957 @default.
• W2397155330 cites W2029912485 @default.
• W2397155330 cites W2041598409 @default.
• W2397155330 cites W2048392906 @default.
• W2397155330 cites W2052411635 @default.
• W2397155330 cites W2067020273 @default.
• W2397155330 cites W2067159071 @default.
• W2397155330 cites W2067757416 @default.
• W2397155330 cites W2076996911 @default.
• W2397155330 cites W2081614214 @default.
• W2397155330 cites W2081960147 @default.
• W2397155330 cites W2094971696 @default.
• W2397155330 cites W2105161755 @default.
• W2397155330 cites W2107159327 @default.
• W2397155330 cites W2116718309 @default.
• W2397155330 cites W2117841430 @default.
• W2397155330 cites W2130191760 @default.
• W2397155330 cites W2138480111 @default.
• W2397155330 cites W2141824178 @default.
• W2397155330 cites W2146977555 @default.
• W2397155330 cites W2159555560 @default.
• W2397155330 cites W2167058119 @default.
• W2397155330 cites W2170090906 @default.
• W2397155330 cites W2193156811 @default.
• W2397155330 cites W2404470138 @default.
• W2397155330 cites W71340409 @default.
• W2397155330 doi "https://doi.org/10.1371/journal.pone.0156033" @default.
• W2397155330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4873024" @default.
• W2397155330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27196066" @default.
• W2397155330 hasPublicationYear "2016" @default.
• W2397155330 type Work @default.
• W2397155330 sameAs 2397155330 @default.
• W2397155330 citedByCount "7" @default.
• W2397155330 countsByYear W23971553302018 @default.
• W2397155330 countsByYear W23971553302019 @default.
• W2397155330 countsByYear W23971553302020 @default.
• W2397155330 countsByYear W23971553302022 @default.
• W2397155330 crossrefType "journal-article" @default.
• W2397155330 hasAuthorship W2397155330A5000466178 @default.
• W2397155330 hasAuthorship W2397155330A5032162260 @default.
• W2397155330 hasAuthorship W2397155330A5058796976 @default.
• W2397155330 hasAuthorship W2397155330A5065422122 @default.
• W2397155330 hasAuthorship W2397155330A5075465842 @default.
• W2397155330 hasAuthorship W2397155330A5076551456 @default.
• W2397155330 hasAuthorship W2397155330A5083426647 @default.
• W2397155330 hasAuthorship W2397155330A5086588508 @default.
• W2397155330 hasBestOaLocation W23971553301 @default.
• W2397155330 hasConcept C104317684 @default.
• W2397155330 hasConcept C153911025 @default.
• W2397155330 hasConcept C169760540 @default.
• W2397155330 hasConcept C194583182 @default.
• W2397155330 hasConcept C2777093970 @default.
• W2397155330 hasConcept C41282012 @default.
• W2397155330 hasConcept C53345823 @default.
• W2397155330 hasConcept C54355233 @default.
• W2397155330 hasConcept C67705224 @default.
• W2397155330 hasConcept C86803240 @default.
• W2397155330 hasConcept C95444343 @default.
• W2397155330 hasConceptScore W2397155330C104317684 @default.
• W2397155330 hasConceptScore W2397155330C153911025 @default.
• W2397155330 hasConceptScore W2397155330C169760540 @default.
• W2397155330 hasConceptScore W2397155330C194583182 @default.
• W2397155330 hasConceptScore W2397155330C2777093970 @default.
• W2397155330 hasConceptScore W2397155330C41282012 @default.
• W2397155330 hasConceptScore W2397155330C53345823 @default.
• W2397155330 hasConceptScore W2397155330C54355233 @default.
• W2397155330 hasConceptScore W2397155330C67705224 @default.
• W2397155330 hasConceptScore W2397155330C86803240 @default.
• W2397155330 hasConceptScore W2397155330C95444343 @default.
• W2397155330 hasFunder F4320309807 @default.

• next