Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397188234> ?p ?o ?g. }
- W2397188234 endingPage "S18" @default.
- W2397188234 startingPage "S8" @default.
- W2397188234 abstract "Bergamot (Citrus bergamia Risso et Poiteau) juice has a particularly high content and a unique composition of flavonoids. Neoeriocitrin, neohesperidin, naringin, melitidin and brutieridin represent more than 95% of Bergamot Polyphenol Fraction (BPF), while rhoifolin, diosmin, poncirin and others can be found in the remaining 5%. The brilliant performance of BPF in clinical practice against as a treatment for hyperlipidemia and moderate hyperglycemia in metabolic syndrome, awaits a plausible mechanistic explanation. Considering the overwhelming scientific evidence, it is likely that flavonoid components of BPF are responsible for majority of pharmacological effects. Here, we will review the scientific evidence showing that flavonoids, in particular citrus flavonoids present in bergamot fruits, influence lipid and sugar metabolism at the molecular level. Anti-diabetic and dyslipidemia-correcting effects of bergamot polyphenols may be explained by their ability to activate AMP kinase (AMPK), which is a central regulator of glucose and fatty acids metabolism and inhibit cAMP phosphodiesterases (PDE), involved in regulation of lipolysis in adipocytes and liver. Importantly, certain polyphenols can act as 3-hydroxy-3-methlglutaryl coenzyme A (HMG-CoA) reductase inhibitors, thereby mimicking statins action. In addition, flavonoids bind and act as natural inhibitors of quinone oxidoreductase 2 (QR2/NQO2) and other enzymes with potential roles in metabolic regulation. Finally, pleiotropic and possible synergistic effects may account for enhanced nutraceutical effects of natural flavonoid mixtures, such as BPF as compared to purified flavonoids." @default.
- W2397188234 created "2016-06-24" @default.
- W2397188234 creator A5006053315 @default.
- W2397188234 creator A5017770306 @default.
- W2397188234 creator A5020588068 @default.
- W2397188234 creator A5023025317 @default.
- W2397188234 creator A5029516464 @default.
- W2397188234 creator A5038338043 @default.
- W2397188234 creator A5067929802 @default.
- W2397188234 creator A5070957587 @default.
- W2397188234 date "2016-10-01" @default.
- W2397188234 modified "2023-09-26" @default.
- W2397188234 title "Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids" @default.
- W2397188234 cites W1481290542 @default.
- W2397188234 cites W1508120154 @default.
- W2397188234 cites W1515390664 @default.
- W2397188234 cites W1525318001 @default.
- W2397188234 cites W1533117723 @default.
- W2397188234 cites W1533767372 @default.
- W2397188234 cites W1738497100 @default.
- W2397188234 cites W1839867987 @default.
- W2397188234 cites W1929522529 @default.
- W2397188234 cites W1966339676 @default.
- W2397188234 cites W1966399667 @default.
- W2397188234 cites W1967532400 @default.
- W2397188234 cites W1967833615 @default.
- W2397188234 cites W1972029250 @default.
- W2397188234 cites W1974850809 @default.
- W2397188234 cites W1975599815 @default.
- W2397188234 cites W1983457087 @default.
- W2397188234 cites W1986851225 @default.
- W2397188234 cites W1987078306 @default.
- W2397188234 cites W1990718598 @default.
- W2397188234 cites W1993012591 @default.
- W2397188234 cites W1997306559 @default.
- W2397188234 cites W1998025316 @default.
- W2397188234 cites W1998178455 @default.
- W2397188234 cites W2003894821 @default.
- W2397188234 cites W2005915142 @default.
- W2397188234 cites W2010894390 @default.
- W2397188234 cites W2015957376 @default.
- W2397188234 cites W2016761176 @default.
- W2397188234 cites W2027442494 @default.
- W2397188234 cites W2028319504 @default.
- W2397188234 cites W2029739963 @default.
- W2397188234 cites W2030266364 @default.
- W2397188234 cites W2030467598 @default.
- W2397188234 cites W2031562023 @default.
- W2397188234 cites W2032156343 @default.
- W2397188234 cites W2035336703 @default.
- W2397188234 cites W2039091641 @default.
- W2397188234 cites W2042503457 @default.
- W2397188234 cites W2043498277 @default.
- W2397188234 cites W2043831656 @default.
- W2397188234 cites W2046406719 @default.
- W2397188234 cites W2051719098 @default.
- W2397188234 cites W2055317640 @default.
- W2397188234 cites W2060428034 @default.
- W2397188234 cites W2062956684 @default.
- W2397188234 cites W2063335530 @default.
- W2397188234 cites W2064807233 @default.
- W2397188234 cites W2073068954 @default.
- W2397188234 cites W2074997034 @default.
- W2397188234 cites W2075441161 @default.
- W2397188234 cites W2075731394 @default.
- W2397188234 cites W2076572520 @default.
- W2397188234 cites W2084062672 @default.
- W2397188234 cites W2086364753 @default.
- W2397188234 cites W2088934129 @default.
- W2397188234 cites W2096170389 @default.
- W2397188234 cites W2096271770 @default.
- W2397188234 cites W2100159014 @default.
- W2397188234 cites W2103450921 @default.
- W2397188234 cites W2110936053 @default.
- W2397188234 cites W2112733885 @default.
- W2397188234 cites W2114825009 @default.
- W2397188234 cites W2120591996 @default.
- W2397188234 cites W2124056180 @default.
- W2397188234 cites W2125121177 @default.
- W2397188234 cites W2125553122 @default.
- W2397188234 cites W2127482883 @default.
- W2397188234 cites W2128627308 @default.
- W2397188234 cites W2129072484 @default.
- W2397188234 cites W2147137265 @default.
- W2397188234 cites W2152150730 @default.
- W2397188234 cites W2158438063 @default.
- W2397188234 cites W2159620999 @default.
- W2397188234 cites W2164573775 @default.
- W2397188234 cites W2165722123 @default.
- W2397188234 cites W2168425425 @default.
- W2397188234 cites W2415307807 @default.
- W2397188234 doi "https://doi.org/10.1016/j.phanu.2016.05.001" @default.
- W2397188234 hasPublicationYear "2016" @default.
- W2397188234 type Work @default.
- W2397188234 sameAs 2397188234 @default.
- W2397188234 citedByCount "30" @default.
- W2397188234 countsByYear W23971882342017 @default.
- W2397188234 countsByYear W23971882342018 @default.