Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397356767> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2397356767 endingPage "7" @default.
- W2397356767 startingPage "272" @default.
- W2397356767 abstract "A plasma membrane glycoprotein (P-gp) of 170 kd is over-expressed in most of the drug resistant cells. P-gp is encoded in humans by the gene mdrl and is thought to function as a broad substrate ATP-dependent drug efflux pump. P-gp is also present in many types of normal cells. A good number of chemicals inhibit or deactivate P-gp and thus reverse multidrug resistance (MDR). Most of the reported resistance modifying agents (RMAs) are effective in vitro and have adverse effect on the hosts. Hence, the development of nontoxic RMA is of immense importance in the field of cancer chemotherapy. With this end in view, a nontoxic resistance modifying agent, viz., oxalyl bis (N-phenyl) hydroxamic acid (OPHA) has been developed on the basis of the structural commonalities of the reported RMAs. We reported earlier that OPHA reverses doxorubicin resistance in vitro and also reduces glutathione and glutathione S-transferase in a non P-gp expressing cell line. In the present report, the inhibition of P-gp by the compound, OPHA in human cervical cancer cell line, HeLa, has been described by western blotting, study of immunofluorescence and enzyme linked immunofluorescence assay (ELISA). The inhibition of P-gp by OPHA is significantly higher than that of verapamil. The high IC50 values of OPHA against different cell lines indicate the non toxic nature of the compound. This work underscores the possibility of using the present hydroxamic acid derivative as the nontoxic modulator of the MDR phenotype." @default.
- W2397356767 created "2016-06-24" @default.
- W2397356767 creator A5075835459 @default.
- W2397356767 date "2002-01-01" @default.
- W2397356767 modified "2023-09-23" @default.
- W2397356767 title "Deactivation of P-glycoprotein by a novel compound, oxalyl bis (N-phenyl) hydroxamic acid." @default.
- W2397356767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12382028" @default.
- W2397356767 hasPublicationYear "2002" @default.
- W2397356767 type Work @default.
- W2397356767 sameAs 2397356767 @default.
- W2397356767 citedByCount "0" @default.
- W2397356767 crossrefType "journal-article" @default.
- W2397356767 hasAuthorship W2397356767A5075835459 @default.
- W2397356767 hasConcept C133936738 @default.
- W2397356767 hasConcept C185592680 @default.
- W2397356767 hasConcept C202751555 @default.
- W2397356767 hasConcept C2776281265 @default.
- W2397356767 hasConcept C2776694085 @default.
- W2397356767 hasConcept C2777366897 @default.
- W2397356767 hasConcept C2777752497 @default.
- W2397356767 hasConcept C2778707650 @default.
- W2397356767 hasConcept C2781303535 @default.
- W2397356767 hasConcept C501593827 @default.
- W2397356767 hasConcept C54355233 @default.
- W2397356767 hasConcept C55493867 @default.
- W2397356767 hasConcept C71240020 @default.
- W2397356767 hasConcept C81885089 @default.
- W2397356767 hasConcept C86803240 @default.
- W2397356767 hasConcept C98274493 @default.
- W2397356767 hasConceptScore W2397356767C133936738 @default.
- W2397356767 hasConceptScore W2397356767C185592680 @default.
- W2397356767 hasConceptScore W2397356767C202751555 @default.
- W2397356767 hasConceptScore W2397356767C2776281265 @default.
- W2397356767 hasConceptScore W2397356767C2776694085 @default.
- W2397356767 hasConceptScore W2397356767C2777366897 @default.
- W2397356767 hasConceptScore W2397356767C2777752497 @default.
- W2397356767 hasConceptScore W2397356767C2778707650 @default.
- W2397356767 hasConceptScore W2397356767C2781303535 @default.
- W2397356767 hasConceptScore W2397356767C501593827 @default.
- W2397356767 hasConceptScore W2397356767C54355233 @default.
- W2397356767 hasConceptScore W2397356767C55493867 @default.
- W2397356767 hasConceptScore W2397356767C71240020 @default.
- W2397356767 hasConceptScore W2397356767C81885089 @default.
- W2397356767 hasConceptScore W2397356767C86803240 @default.
- W2397356767 hasConceptScore W2397356767C98274493 @default.
- W2397356767 hasIssue "4" @default.
- W2397356767 hasLocation W23973567671 @default.
- W2397356767 hasOpenAccess W2397356767 @default.
- W2397356767 hasPrimaryLocation W23973567671 @default.
- W2397356767 hasRelatedWork W2044769069 @default.
- W2397356767 hasRelatedWork W2062338537 @default.
- W2397356767 hasRelatedWork W2065890465 @default.
- W2397356767 hasRelatedWork W2077865136 @default.
- W2397356767 hasRelatedWork W2078998991 @default.
- W2397356767 hasRelatedWork W2094809302 @default.
- W2397356767 hasRelatedWork W2100596948 @default.
- W2397356767 hasRelatedWork W2155533610 @default.
- W2397356767 hasRelatedWork W2328605846 @default.
- W2397356767 hasRelatedWork W2397356767 @default.
- W2397356767 hasVolume "49" @default.
- W2397356767 isParatext "false" @default.
- W2397356767 isRetracted "false" @default.
- W2397356767 magId "2397356767" @default.
- W2397356767 workType "article" @default.