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- W2397366455 abstract "Objective To investigate the effects of SF injection on coagulation function, p-selectin and D-dimer concentrations in plasma of elderly patients undergoing total hip replacemen(THR). Methods Twenty-four ASA Ⅱ/ Ⅲ patients aged 65 to 85 were divided equally into two groups (n = 12). In Group S, SF injection was administered by peripheral intravenous infusion at initially 0. 2 ml/kg and then 0. 8 ml(kg/h) until the end of operations. In Group N, normal saline was administered similarly. All the patients were given patient-controlled epidural analgesia (PCEA) after operations. Blood samples were taken before operations ( T0 ), immediately post-operation ( T1 ) and 24 h post-operation to detect the levels of p-selectin, D-dimer, blood platelet count and clotting time at all time points. Results The concentrations of p-selectin and D-dimer in Group N increased at T1 and T2 while those in Group S decreased at T1 (P ＜0. 05). Compared with Group N, they were significantly lower in Group S ( P ＜ 0. 05 ). There was no significant difference at T2 between two groups. Conclusion The plasma concentrations of p-selectin and Ddimer increase obviously in elderly THR patients. SF injection can decrease the plasma concentrations of pselectin and D-dimer in patients during surgery. Thus it may protect the vascular endothelial cells and attenuate the activation of platelet and fibrinolysis.Key words: Arthroplasty,replacement,hip; Injections,intravenous; Blood coagulation" @default.
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- W2397366455 date "2010-08-03" @default.
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- W2397366455 title "Effects of Shenfu injection on coagulation function, D-dimer and plasma p-selectin in elderly patients during total hip replacement surgery" @default.
- W2397366455 doi "https://doi.org/10.3760/cma.j.issn.0376-2491.2010.29.007" @default.
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