Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397469175> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2397469175 endingPage "40" @default.
- W2397469175 startingPage "635" @default.
- W2397469175 abstract "OBJECTIVE To assess the value of quantitative fluorescence PCR (QF-PCR) for the prenatal diagnosis of common fetal chromosomal aneuploidies. METHODS A total of 2436 amniotic fluid samples were collected at 18 to 22 gestational weeks. Multiplex QF-PCR was performed with fluorescence-labeled primers specific for 32 polymorphic short tandem repeat (STR) sites on chromosomes 21, 18, 13, X and Y. The PCR products were assayed by capillary electrophoresis. All samples were also assayed by karyotyping. RESULTS Seventy-six (3.12%) samples were diagnosed as chromosomal aneuploidies by QF-PCR, among which 51 were trisomy 21, 12 were trisomy 18, 2 were trisomy 13, and 1 was triploidy. The results were all consistent with those of karyotyping. Ten samples were suspected as sex chromosomal aneuploidies, among which 9 were confirmed, except for 1 case with X structural abnormality. In addition, karyotyping has diagnosed 24 (0.99%) cases of structural abnormalities, only one of which was suspected by QF-PCR with partial abnormal STR results. Two (0.08%) samples were found to be mosaic by karyotyping, one of which was suggested by QF-PCR with cut-off ratios of STR markers. CONCLUSION QF-PCR is reliable for the diagnosis of numerical abnormalities of chromosomes 21, 18, 13, X and Y. The method can serve as an effective technique for rapid prenatal screening of common chromosome aneuploidies in fetus." @default.
- W2397469175 created "2016-06-24" @default.
- W2397469175 creator A5000892548 @default.
- W2397469175 creator A5002188808 @default.
- W2397469175 creator A5016048028 @default.
- W2397469175 creator A5029562127 @default.
- W2397469175 creator A5030060042 @default.
- W2397469175 date "2015-10-01" @default.
- W2397469175 modified "2023-09-23" @default.
- W2397469175 title "[Application of quantitative fluorescence PCR for the prenatal diagnosis of common fetal chromosomal aneuploidies]." @default.
- W2397469175 doi "https://doi.org/10.3760/cma.j.issn.1003-9406.2015.05.006" @default.
- W2397469175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26418981" @default.
- W2397469175 hasPublicationYear "2015" @default.
- W2397469175 type Work @default.
- W2397469175 sameAs 2397469175 @default.
- W2397469175 citedByCount "0" @default.
- W2397469175 crossrefType "journal-article" @default.
- W2397469175 hasAuthorship W2397469175A5000892548 @default.
- W2397469175 hasAuthorship W2397469175A5002188808 @default.
- W2397469175 hasAuthorship W2397469175A5016048028 @default.
- W2397469175 hasAuthorship W2397469175A5029562127 @default.
- W2397469175 hasAuthorship W2397469175A5030060042 @default.
- W2397469175 hasConcept C104317684 @default.
- W2397469175 hasConcept C142724271 @default.
- W2397469175 hasConcept C153911025 @default.
- W2397469175 hasConcept C172680121 @default.
- W2397469175 hasConcept C2776229224 @default.
- W2397469175 hasConcept C2778194526 @default.
- W2397469175 hasConcept C2778258057 @default.
- W2397469175 hasConcept C2779234561 @default.
- W2397469175 hasConcept C2779672484 @default.
- W2397469175 hasConcept C2781188995 @default.
- W2397469175 hasConcept C30481170 @default.
- W2397469175 hasConcept C53226629 @default.
- W2397469175 hasConcept C54355233 @default.
- W2397469175 hasConcept C71924100 @default.
- W2397469175 hasConcept C86803240 @default.
- W2397469175 hasConceptScore W2397469175C104317684 @default.
- W2397469175 hasConceptScore W2397469175C142724271 @default.
- W2397469175 hasConceptScore W2397469175C153911025 @default.
- W2397469175 hasConceptScore W2397469175C172680121 @default.
- W2397469175 hasConceptScore W2397469175C2776229224 @default.
- W2397469175 hasConceptScore W2397469175C2778194526 @default.
- W2397469175 hasConceptScore W2397469175C2778258057 @default.
- W2397469175 hasConceptScore W2397469175C2779234561 @default.
- W2397469175 hasConceptScore W2397469175C2779672484 @default.
- W2397469175 hasConceptScore W2397469175C2781188995 @default.
- W2397469175 hasConceptScore W2397469175C30481170 @default.
- W2397469175 hasConceptScore W2397469175C53226629 @default.
- W2397469175 hasConceptScore W2397469175C54355233 @default.
- W2397469175 hasConceptScore W2397469175C71924100 @default.
- W2397469175 hasConceptScore W2397469175C86803240 @default.
- W2397469175 hasIssue "5" @default.
- W2397469175 hasLocation W23974691751 @default.
- W2397469175 hasOpenAccess W2397469175 @default.
- W2397469175 hasPrimaryLocation W23974691751 @default.
- W2397469175 hasRelatedWork W1964359181 @default.
- W2397469175 hasRelatedWork W2066202396 @default.
- W2397469175 hasRelatedWork W2092123776 @default.
- W2397469175 hasRelatedWork W2131159740 @default.
- W2397469175 hasRelatedWork W2381261220 @default.
- W2397469175 hasRelatedWork W2390713779 @default.
- W2397469175 hasRelatedWork W2808456119 @default.
- W2397469175 hasRelatedWork W3031877374 @default.
- W2397469175 hasRelatedWork W4284988655 @default.
- W2397469175 hasRelatedWork W1857586080 @default.
- W2397469175 hasVolume "32" @default.
- W2397469175 isParatext "false" @default.
- W2397469175 isRetracted "false" @default.
- W2397469175 magId "2397469175" @default.
- W2397469175 workType "article" @default.