Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397495531> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2397495531 endingPage "22" @default.
- W2397495531 startingPage "117" @default.
- W2397495531 abstract "The guanine analogue, queuine (q), is a nutrition factor for eukaryotes and occurs as a free base or as modified nucleoside queuosine (Q) inserted into the anticodon of tRNAs(GUN) in place of guanosine (G). The free q-base and the corresponding Q-deficient tRNAs accumulate in fast proliferating tumors and in embryonic cells. The present data show that treatment of Q-deficient HeLa cells with queuine resulted in reduced in vitro phosphorylation of two membrane-associated proteins, pp110 and pp18. Reduced phosphorylation of pp110 and pp18 was also observed when a membrane-containing particulate fraction from queuine starved HeLa cells was labelled with [gamma-32P]ATP in the presence of queuine. Incorporated phosphate into pp110 was alkali-stable, suggesting that this protein became phosphorylated at tyrosine residues. After stimulation of intact Q-deficient cells with epidermal growth factor, pp110 was rapidly phosphorylated at tyrosine residues. The results show that queuine as a free base influences protein tyrosine phosphorylation in intact cells, suggesting that it might interfere with protein phosphorylation involved in signal transduction pathways." @default.
- W2397495531 created "2016-06-24" @default.
- W2397495531 creator A5065820344 @default.
- W2397495531 date "1993-05-01" @default.
- W2397495531 modified "2023-09-23" @default.
- W2397495531 title "Changes of the phosphorylation of membrane-associated proteins following treatment of HeLa cells with the guanine analogue, queuine." @default.
- W2397495531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7688512" @default.
- W2397495531 hasPublicationYear "1993" @default.
- W2397495531 type Work @default.
- W2397495531 sameAs 2397495531 @default.
- W2397495531 citedByCount "1" @default.
- W2397495531 crossrefType "journal-article" @default.
- W2397495531 hasAuthorship W2397495531A5065820344 @default.
- W2397495531 hasConcept C104317684 @default.
- W2397495531 hasConcept C11960822 @default.
- W2397495531 hasConcept C2776165026 @default.
- W2397495531 hasConcept C2777553839 @default.
- W2397495531 hasConcept C2777995097 @default.
- W2397495531 hasConcept C2778301229 @default.
- W2397495531 hasConcept C512185932 @default.
- W2397495531 hasConcept C55493867 @default.
- W2397495531 hasConcept C86803240 @default.
- W2397495531 hasConcept C87325107 @default.
- W2397495531 hasConcept C97029542 @default.
- W2397495531 hasConceptScore W2397495531C104317684 @default.
- W2397495531 hasConceptScore W2397495531C11960822 @default.
- W2397495531 hasConceptScore W2397495531C2776165026 @default.
- W2397495531 hasConceptScore W2397495531C2777553839 @default.
- W2397495531 hasConceptScore W2397495531C2777995097 @default.
- W2397495531 hasConceptScore W2397495531C2778301229 @default.
- W2397495531 hasConceptScore W2397495531C512185932 @default.
- W2397495531 hasConceptScore W2397495531C55493867 @default.
- W2397495531 hasConceptScore W2397495531C86803240 @default.
- W2397495531 hasConceptScore W2397495531C87325107 @default.
- W2397495531 hasConceptScore W2397495531C97029542 @default.
- W2397495531 hasIssue "2" @default.
- W2397495531 hasLocation W23974955311 @default.
- W2397495531 hasOpenAccess W2397495531 @default.
- W2397495531 hasPrimaryLocation W23974955311 @default.
- W2397495531 hasRelatedWork W1531825933 @default.
- W2397495531 hasRelatedWork W1562710579 @default.
- W2397495531 hasRelatedWork W1976908689 @default.
- W2397495531 hasRelatedWork W1987860905 @default.
- W2397495531 hasRelatedWork W2020608970 @default.
- W2397495531 hasRelatedWork W2077261875 @default.
- W2397495531 hasRelatedWork W2142130323 @default.
- W2397495531 hasRelatedWork W2397495531 @default.
- W2397495531 hasRelatedWork W2412949585 @default.
- W2397495531 hasRelatedWork W4253704295 @default.
- W2397495531 hasVolume "4" @default.
- W2397495531 isParatext "false" @default.
- W2397495531 isRetracted "false" @default.
- W2397495531 magId "2397495531" @default.
- W2397495531 workType "article" @default.