FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397519005> ?p ?o ?g. }

• W2397519005 endingPage "e1004915" @default.
• W2397519005 startingPage "e1004915" @default.
• W2397519005 abstract "The inherent complexity of biological systems gives rise to complicated mechanistic models with a large number of parameters. On the other hand, the collective behavior of these systems can often be characterized by a relatively small number of phenomenological parameters. We use the Manifold Boundary Approximation Method (MBAM) as a tool for deriving simple phenomenological models from complicated mechanistic models. The resulting models are not black boxes, but remain expressed in terms of the microscopic parameters. In this way, we explicitly connect the macroscopic and microscopic descriptions, characterize the equivalence class of distinct systems exhibiting the same range of collective behavior, and identify the combinations of components that function as tunable control knobs for the behavior. We demonstrate the procedure for adaptation behavior exhibited by the EGFR pathway. From a 48 parameter mechanistic model, the system can be effectively described by a single adaptation parameter τ characterizing the ratio of time scales for the initial response and recovery time of the system which can in turn be expressed as a combination of microscopic reaction rates, Michaelis-Menten constants, and biochemical concentrations. The situation is not unlike modeling in physics in which microscopically complex processes can often be renormalized into simple phenomenological models with only a few effective parameters. The proposed method additionally provides a mechanistic explanation for non-universal features of the behavior." @default.
• W2397519005 created "2016-06-24" @default.
• W2397519005 creator A5041343853 @default.
• W2397519005 creator A5048733359 @default.
• W2397519005 date "2016-05-17" @default.
• W2397519005 modified "2023-10-13" @default.
• W2397519005 title "Bridging Mechanistic and Phenomenological Models of Complex Biological Systems" @default.
• W2397519005 cites W1486453207 @default.
• W2397519005 cites W1527010484 @default.
• W2397519005 cites W155102939 @default.
• W2397519005 cites W1644749979 @default.
• W2397519005 cites W1757084193 @default.
• W2397519005 cites W1862800359 @default.
• W2397519005 cites W1869042642 @default.
• W2397519005 cites W1881146567 @default.
• W2397519005 cites W1882735145 @default.
• W2397519005 cites W1972452616 @default.
• W2397519005 cites W1976446798 @default.
• W2397519005 cites W1977943300 @default.
• W2397519005 cites W199310666 @default.
• W2397519005 cites W1994613299 @default.
• W2397519005 cites W2000619385 @default.
• W2397519005 cites W2006874219 @default.
• W2397519005 cites W2010740413 @default.
• W2397519005 cites W2014382043 @default.
• W2397519005 cites W2019285183 @default.
• W2397519005 cites W2030760849 @default.
• W2397519005 cites W2038398800 @default.
• W2397519005 cites W2042439614 @default.
• W2397519005 cites W2043276874 @default.
• W2397519005 cites W2044394043 @default.
• W2397519005 cites W2046042332 @default.
• W2397519005 cites W2051594535 @default.
• W2397519005 cites W2053874495 @default.
• W2397519005 cites W2062546738 @default.
• W2397519005 cites W2069647329 @default.
• W2397519005 cites W2077259222 @default.
• W2397519005 cites W2078760718 @default.
• W2397519005 cites W2081974879 @default.
• W2397519005 cites W2086215140 @default.
• W2397519005 cites W2087636279 @default.
• W2397519005 cites W2096605014 @default.
• W2397519005 cites W2100560953 @default.
• W2397519005 cites W2101258119 @default.
• W2397519005 cites W2105437542 @default.
• W2397519005 cites W2116361328 @default.
• W2397519005 cites W2117589890 @default.
• W2397519005 cites W2123973944 @default.
• W2397519005 cites W2128362727 @default.
• W2397519005 cites W2137250701 @default.
• W2397519005 cites W2161304688 @default.
• W2397519005 cites W2161682775 @default.
• W2397519005 cites W2166565152 @default.
• W2397519005 cites W2167485946 @default.
• W2397519005 cites W2182229987 @default.
• W2397519005 cites W2315083496 @default.
• W2397519005 cites W4234623988 @default.
• W2397519005 doi "https://doi.org/10.1371/journal.pcbi.1004915" @default.
• W2397519005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4871498" @default.
• W2397519005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27187545" @default.
• W2397519005 hasPublicationYear "2016" @default.
• W2397519005 type Work @default.
• W2397519005 sameAs 2397519005 @default.
• W2397519005 citedByCount "54" @default.
• W2397519005 countsByYear W23975190052016 @default.
• W2397519005 countsByYear W23975190052017 @default.
• W2397519005 countsByYear W23975190052018 @default.
• W2397519005 countsByYear W23975190052019 @default.
• W2397519005 countsByYear W23975190052020 @default.
• W2397519005 countsByYear W23975190052021 @default.
• W2397519005 countsByYear W23975190052022 @default.
• W2397519005 countsByYear W23975190052023 @default.
• W2397519005 crossrefType "journal-article" @default.
• W2397519005 hasAuthorship W2397519005A5041343853 @default.
• W2397519005 hasAuthorship W2397519005A5048733359 @default.
• W2397519005 hasBestOaLocation W23975190051 @default.
• W2397519005 hasConcept C100339178 @default.
• W2397519005 hasConcept C111472728 @default.
• W2397519005 hasConcept C120665830 @default.
• W2397519005 hasConcept C121332964 @default.
• W2397519005 hasConcept C121864883 @default.
• W2397519005 hasConcept C138885662 @default.
• W2397519005 hasConcept C139807058 @default.
• W2397519005 hasConcept C14036430 @default.
• W2397519005 hasConcept C144024400 @default.
• W2397519005 hasConcept C154945302 @default.
• W2397519005 hasConcept C174348530 @default.
• W2397519005 hasConcept C186060115 @default.
• W2397519005 hasConcept C19165224 @default.
• W2397519005 hasConcept C202444582 @default.
• W2397519005 hasConcept C2779569378 @default.
• W2397519005 hasConcept C2780069185 @default.
• W2397519005 hasConcept C2780586882 @default.
• W2397519005 hasConcept C31258907 @default.
• W2397519005 hasConcept C33923547 @default.
• W2397519005 hasConcept C41008148 @default.
• W2397519005 hasConcept C47822265 @default.
• W2397519005 hasConcept C62520636 @default.

• next