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- W2397532101 abstract "Picryl chloride-induced irritant reaction (IR) was shown to be mediated by tumor necrosis factor (TNF). Anti-TNF monoclonal antibodies, but not interleukin 1 receptor antagonist (IL-1 Ra), had a protective effect. Chlorpromazine (CPZ), an inhibitor of TNF synthesis, protected against IR and inhibited the IR-associated TNF induction in ear homogenates. Investigation of the role of polymorphonuclear leukocyte (PMN) in neutropenic mice showed that neutropenia did not prevent the development of the IR." @default.
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- W2397532101 date "1995-01-01" @default.
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- W2397532101 title "Protective effect of chlorpromazine on TNF-mediated hapten-induced irritant reaction." @default.
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