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- W2397673513 abstract "In creating the osmotic gradient between the mucosa and the serous surface of the urinary bladder of the frog the flow of water from the bladder may be intensified by adding pituitrin into the solution, irrigating the serous surface. Addition of some changes to the solution considerably decreases this effect of pituitrin. The most marked antipituitrin action (of the 30 agents studied) is possessed by diprazin (phenergan) and tifen, which in a concentration of 1.10−5 to 1.10−6 decreased the effect of pituitrin. The antipituitrin effect is not connected with the intensity of the antihistaminic properties of the substances studied. In passing from the tertiary amines to the corresponding quaternary ammonium bases the antipituitrin action disappears. The data obtained may serve as a basis for the search for diuretics capable of depressing the antidiuretic hormone and of increasing the excretion of osmotically free water." @default.
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- W2397673513 date "1964-01-01" @default.
- W2397673513 modified "2023-10-14" @default.
- W2397673513 title "The search for drugs to depress the action of antidiuretic hormone" @default.
- W2397673513 cites W2014090075 @default.
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- W2397673513 doi "https://doi.org/10.1007/bf00783475" @default.
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