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- W2397679898 abstract "We have investigated some covalent interactions of Rauscher leukemia virus (RLV) with the potent carcinogen (±)7β,8α,-dihydroxy-9α,10α,epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). Using sodium dodecyl sulfate-polyacrylamide gel electrophoresis to assay protein binding, we found that BPDE can penetrate the RLV envelope and bind covalently to all structural virus proteins, and that the permeability of the viral envelope toward BPDE displays a bimodal temperature dependence with a minimum near room temperature. Once inside the virus, BPDE binds preferentially to the histone-like p10 molecules, possibly because the basic amino acid residues of this nucleic acid-binding protein are readily available for reaction with BPDE. In contrast, the amount of BPDE bound to gag gene coded p15 was only about 25% of the amount bound to p10 in intact virions. However, when preparations of heat-disrupted virus were used, we found almost equal amounts of binding to p1O and p15. These results suggest that in intact virions p15 molecules are not accessible for reaction with BPDE, possibly because this hydrophobic protein is an integral protein of the RLV envelope (M. Barbacid and S. A. Aaronson, J. Biol. Chem.253, 1408–1414, 1978). Further, when BPDE is incubated with preparations of intact virus for periods greater than 20 min, it apparently interacts strongly with the viral RNA-dependent DNA polymerase to inhibit reverse transcription of an exogenous poly(A) template. But it does not increase the rate of misincorporation of noncomplementary bases (dC) over the inherent rate." @default.
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- W2397679898 title "Interaction of retroviruses with chemical carcinogens" @default.
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- W2397679898 doi "https://doi.org/10.1016/0003-9861(80)90073-9" @default.
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