Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397714095> ?p ?o ?g. }
- W2397714095 abstract "Abstract Campylobacter jejuni is a predominant cause of human gastroenteritis worldwide. Source-attribution studies indicate that chickens are the main reservoir for infection, thus elimination of C. jejuni from poultry would significantly reduce the burden of human disease. We constructed glycoconjugate vaccines combining the conserved C. jejuni N-glycan with a protein carrier, GlycoTag, or fused to the Escherichia coli lipopolysaccharide-core. Vaccination of chickens with the protein-based or E. coli -displayed glycoconjugate showed up to 10-log reduction in C. jejuni colonization and induced N-glycan-specific IgY responses. Moreover, the live E. coli vaccine was cleared prior to C. jejuni challenge and no selection for resistant campylobacter variants was observed. Analyses of the chicken gut communities revealed that the live vaccine did not alter the composition or complexity of the microbiome, thus representing an effective and low-cost strategy to reduce C. jejuni in chickens and its subsequent entry into the food chain." @default.
- W2397714095 created "2016-06-24" @default.
- W2397714095 creator A5005724388 @default.
- W2397714095 creator A5018235838 @default.
- W2397714095 creator A5021951963 @default.
- W2397714095 creator A5024717527 @default.
- W2397714095 creator A5033516292 @default.
- W2397714095 creator A5047702426 @default.
- W2397714095 creator A5060648419 @default.
- W2397714095 creator A5076815423 @default.
- W2397714095 date "2016-05-25" @default.
- W2397714095 modified "2023-10-01" @default.
- W2397714095 title "Engineering the Campylobacter jejuni N-glycan to create an effective chicken vaccine" @default.
- W2397714095 cites W1853727284 @default.
- W2397714095 cites W1914323123 @default.
- W2397714095 cites W1943024006 @default.
- W2397714095 cites W1953840377 @default.
- W2397714095 cites W1963964459 @default.
- W2397714095 cites W1972435343 @default.
- W2397714095 cites W1975352838 @default.
- W2397714095 cites W1976852236 @default.
- W2397714095 cites W1977101213 @default.
- W2397714095 cites W1979456422 @default.
- W2397714095 cites W1983339757 @default.
- W2397714095 cites W1996401266 @default.
- W2397714095 cites W1998364116 @default.
- W2397714095 cites W2003147598 @default.
- W2397714095 cites W2003895492 @default.
- W2397714095 cites W2009926857 @default.
- W2397714095 cites W2010927211 @default.
- W2397714095 cites W2019160016 @default.
- W2397714095 cites W2021115141 @default.
- W2397714095 cites W2022801349 @default.
- W2397714095 cites W2031395967 @default.
- W2397714095 cites W2031406182 @default.
- W2397714095 cites W2054583152 @default.
- W2397714095 cites W2057028229 @default.
- W2397714095 cites W2057746244 @default.
- W2397714095 cites W2059242915 @default.
- W2397714095 cites W2063683785 @default.
- W2397714095 cites W2064193137 @default.
- W2397714095 cites W2067359751 @default.
- W2397714095 cites W2072258127 @default.
- W2397714095 cites W2074879055 @default.
- W2397714095 cites W2075797628 @default.
- W2397714095 cites W2081414533 @default.
- W2397714095 cites W2088221752 @default.
- W2397714095 cites W2092393551 @default.
- W2397714095 cites W2097313256 @default.
- W2397714095 cites W2099796660 @default.
- W2397714095 cites W2102112996 @default.
- W2397714095 cites W2102340583 @default.
- W2397714095 cites W2103706295 @default.
- W2397714095 cites W2105157366 @default.
- W2397714095 cites W2106600347 @default.
- W2397714095 cites W2107164117 @default.
- W2397714095 cites W2108741450 @default.
- W2397714095 cites W2108832457 @default.
- W2397714095 cites W2109396279 @default.
- W2397714095 cites W2109715893 @default.
- W2397714095 cites W2111967267 @default.
- W2397714095 cites W2112647387 @default.
- W2397714095 cites W2112765785 @default.
- W2397714095 cites W2112879979 @default.
- W2397714095 cites W2113746382 @default.
- W2397714095 cites W2116451545 @default.
- W2397714095 cites W2116817862 @default.
- W2397714095 cites W2117398483 @default.
- W2397714095 cites W2117752663 @default.
- W2397714095 cites W2120244959 @default.
- W2397714095 cites W2120904752 @default.
- W2397714095 cites W2124030128 @default.
- W2397714095 cites W2124052868 @default.
- W2397714095 cites W2141390821 @default.
- W2397714095 cites W2142993603 @default.
- W2397714095 cites W2150764734 @default.
- W2397714095 cites W2153273043 @default.
- W2397714095 cites W2156512781 @default.
- W2397714095 cites W2157102043 @default.
- W2397714095 cites W2160993282 @default.
- W2397714095 cites W2161171034 @default.
- W2397714095 cites W2162102848 @default.
- W2397714095 cites W2162203023 @default.
- W2397714095 cites W2163255170 @default.
- W2397714095 cites W2313375653 @default.
- W2397714095 cites W2320870795 @default.
- W2397714095 cites W2327165497 @default.
- W2397714095 cites W2331030431 @default.
- W2397714095 cites W2395682772 @default.
- W2397714095 cites W4322700637 @default.
- W2397714095 doi "https://doi.org/10.1038/srep26511" @default.
- W2397714095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4879521" @default.
- W2397714095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27221144" @default.
- W2397714095 hasPublicationYear "2016" @default.
- W2397714095 type Work @default.
- W2397714095 sameAs 2397714095 @default.
- W2397714095 citedByCount "69" @default.
- W2397714095 countsByYear W23977140952016 @default.
- W2397714095 countsByYear W23977140952017 @default.
- W2397714095 countsByYear W23977140952018 @default.