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• W2397719271 abstract "Few studies have considered the joint associa- tion of body mass index (BMI) and physical activity, two modifiable factors, with all-cause mortality after breast cancer diagnosis. Women diagnosed with invasive breast cancer (n = 4,153) between 1991 and 2000 were enrolled in the Breast Cancer Family Registry through population- based sampling in Northern California, USA; Ontario, Canada; and Melbourne and Sydney, Australia. During a median follow-up of 7.8 years, 725 deaths occurred. Baseline questionnaires assessed moderate and vigorous recreational physical activity and BMI prior to diagnosis. Associations with all-cause mortality were assessed using Cox proportional hazards regression, adjusting for established prognostic factors. Compared with no physical activity, any recreational activity during the 3 years prior to diag- nosis was associated with a 34% lower risk of death (hazard ratio (HR) = 0.66, 95% confidence interval (CI): 0.51-0.85) for women with estrogen receptor (ER)-positive tumors, but not those with ER-negative tumors; this asso- ciation did not appear to differ by race/ethnicity or BMI. Lifetime physical activity was not associated with all-cause mortality. BMI was positively associated with all-cause mortality for women diagnosed at age C50 years with ER- positive tumors (compared with normal-weight women, HR for overweight = 1.39, 95% CI: 0.90-2.15; HR for obese = 1.77, 95% CI: 1.11-2.82). BMI associations did" @default.
• W2397719271 created "2016-06-24" @default.
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• W2397719271 date "2010-01-01" @default.
• W2397719271 modified "2023-09-27" @default.
• W2397719271 title "Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the breast cancer family registry Theresa H. M. KeeganRoger L. MilneIrene L. AndrulisEllen T. Chang • Meera SangaramoorthyKelly-Anne PhillipsGraham G. GilesPamela J. Goodwin • Carmel ApicellaJohn L. HopperAlice S. WhittemoreEsther M. John" @default.
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