FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397756710> ?p ?o ?g. }

• W2397756710 abstract "Infections caused by bacteria or viruses are frequent in common variable immunodeficiency (CVID) patients due to antibody deficiencies, which may be associated with altered T cell function. CVID patients are frequently in contact with pathogen-associated molecular patterns (PAMPs), leading to the activation of innate immunity through Toll-like receptors (TLR) affecting T cell activation. We evaluated the effect of TLR activation on T cells in CVID patients undergoing intravenous immunoglobulin (IVIg) replacement using synthetic ligands.Expression of exhaustion, activation and maturation markers on T cells from peripheral blood as well as regulatory T cells and follicular T cells in peripheral blood mononuclear cells (PBMCs) from CVID and healthy individuals were evaluated by flow cytometry. PBMCs cultured with TLR agonists were assessed for intracellular IFN-γ, TNF, IL-10, IL-17a or IL-22 secretion as monofunctional or polyfunctional T cells (simultaneous cytokine secretion) by flow cytometry.We found increased expression of the exhaustion marker PD-1 on effector memory CD4(+) T cells (CD45RA(-)CCR7(-)) in the peripheral blood and increased expression of CD38 in terminally differentiated CD8(+) T cells (CD45RA(+)CCR7(-)). Furthermore, a decreased frequency of naïve regulatory T cells (CD45RA(+)Foxp3(low)), but not of activated regulatory T cells (CD45RA(-)Foxp3(high)) was detected in CVID patients with splenomegaly, the non-infectious manifestation in this CVID cohort (43.7 %). Moreover, the frequency of peripheral blood follicular helper T cells (CD3(+)CD4(+)CXCR5(+)PD-1(+)ICOS(+)) was similar between the CVID and control groups. Upon in vitro TLR3 activation, a decreased frequency of CD8(+) T cells secreting IFN-γ, IL-17a or IL-22 was detected in the CVID group compared to the control group. However, a TLR7/TLR8 agonist and staphylococcal enterotoxin B induced an increased Th22/Tc22 (IL-22(+), IFN-γ(-), IL-17a(-)) response in CVID patients. Both TLR2 and TLR7/8/CL097 activation induced an increased response of CD4(+) T cells secreting three cytokines (IL-17a, IL-22 and TNF)in CVID patients, whereas CD8(+) T cells were unresponsive to these stimuli.The data show that despite the unresponsive profile of CD8(+) T cells to TLR activation, CD4(+) T cells and Tc22/Th22 cells are responsive, suggesting that activation of innate immunity by TLRs could be a strategy to stimulate CD4(+) T cells in CVID." @default.
• W2397756710 created "2016-06-24" @default.
• W2397756710 creator A5002506097 @default.
• W2397756710 creator A5027505271 @default.
• W2397756710 creator A5045814232 @default.
• W2397756710 creator A5057592645 @default.
• W2397756710 creator A5079456545 @default.
• W2397756710 creator A5085211757 @default.
• W2397756710 creator A5089876011 @default.
• W2397756710 creator A5090554872 @default.
• W2397756710 date "2016-05-17" @default.
• W2397756710 modified "2023-09-25" @default.
• W2397756710 title "Impaired CD8+ T cell responses upon Toll-like receptor activation in common variable immunodeficiency" @default.
• W2397756710 cites W1506126816 @default.
• W2397756710 cites W1605796307 @default.
• W2397756710 cites W1770811198 @default.
• W2397756710 cites W1981229997 @default.
• W2397756710 cites W1983366728 @default.
• W2397756710 cites W1994624777 @default.
• W2397756710 cites W1995738251 @default.
• W2397756710 cites W2007631222 @default.
• W2397756710 cites W2009370591 @default.
• W2397756710 cites W2010643338 @default.
• W2397756710 cites W2016261682 @default.
• W2397756710 cites W2024502371 @default.
• W2397756710 cites W2025477540 @default.
• W2397756710 cites W2034507166 @default.
• W2397756710 cites W2038600671 @default.
• W2397756710 cites W2040886654 @default.
• W2397756710 cites W2044859167 @default.
• W2397756710 cites W2050528176 @default.
• W2397756710 cites W2052044919 @default.
• W2397756710 cites W2057121293 @default.
• W2397756710 cites W2059323776 @default.
• W2397756710 cites W2082450021 @default.
• W2397756710 cites W2089996985 @default.
• W2397756710 cites W2098542011 @default.
• W2397756710 cites W2099658042 @default.
• W2397756710 cites W2101909968 @default.
• W2397756710 cites W2103704908 @default.
• W2397756710 cites W2106464597 @default.
• W2397756710 cites W2109491705 @default.
• W2397756710 cites W2114637517 @default.
• W2397756710 cites W2117613919 @default.
• W2397756710 cites W2124241330 @default.
• W2397756710 cites W2134717682 @default.
• W2397756710 cites W2141649011 @default.
• W2397756710 cites W2151758954 @default.
• W2397756710 cites W2159816032 @default.
• W2397756710 cites W2572233504 @default.
• W2397756710 doi "https://doi.org/10.1186/s12967-016-0900-2" @default.
• W2397756710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4870753" @default.
• W2397756710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27188997" @default.
• W2397756710 hasPublicationYear "2016" @default.
• W2397756710 type Work @default.
• W2397756710 sameAs 2397756710 @default.
• W2397756710 citedByCount "11" @default.
• W2397756710 countsByYear W23977567102017 @default.
• W2397756710 countsByYear W23977567102018 @default.
• W2397756710 countsByYear W23977567102019 @default.
• W2397756710 countsByYear W23977567102020 @default.
• W2397756710 countsByYear W23977567102021 @default.
• W2397756710 countsByYear W23977567102022 @default.
• W2397756710 countsByYear W23977567102023 @default.
• W2397756710 crossrefType "journal-article" @default.
• W2397756710 hasAuthorship W2397756710A5002506097 @default.
• W2397756710 hasAuthorship W2397756710A5027505271 @default.
• W2397756710 hasAuthorship W2397756710A5045814232 @default.
• W2397756710 hasAuthorship W2397756710A5057592645 @default.
• W2397756710 hasAuthorship W2397756710A5079456545 @default.
• W2397756710 hasAuthorship W2397756710A5085211757 @default.
• W2397756710 hasAuthorship W2397756710A5089876011 @default.
• W2397756710 hasAuthorship W2397756710A5090554872 @default.
• W2397756710 hasBestOaLocation W23977567101 @default.
• W2397756710 hasConcept C10205521 @default.
• W2397756710 hasConcept C127801297 @default.
• W2397756710 hasConcept C12823836 @default.
• W2397756710 hasConcept C13373296 @default.
• W2397756710 hasConcept C137061746 @default.
• W2397756710 hasConcept C159654299 @default.
• W2397756710 hasConcept C159912055 @default.
• W2397756710 hasConcept C167672396 @default.
• W2397756710 hasConcept C202751555 @default.
• W2397756710 hasConcept C203014093 @default.
• W2397756710 hasConcept C2776090121 @default.
• W2397756710 hasConcept C2776433325 @default.
• W2397756710 hasConcept C2779727006 @default.
• W2397756710 hasConcept C28328180 @default.
• W2397756710 hasConcept C55493867 @default.
• W2397756710 hasConcept C71924100 @default.
• W2397756710 hasConcept C79484868 @default.
• W2397756710 hasConcept C86803240 @default.
• W2397756710 hasConcept C8891405 @default.
• W2397756710 hasConcept C95444343 @default.
• W2397756710 hasConceptScore W2397756710C10205521 @default.
• W2397756710 hasConceptScore W2397756710C127801297 @default.
• W2397756710 hasConceptScore W2397756710C12823836 @default.
• W2397756710 hasConceptScore W2397756710C13373296 @default.
• W2397756710 hasConceptScore W2397756710C137061746 @default.
• W2397756710 hasConceptScore W2397756710C159654299 @default.

• next