Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397767360> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2397767360 endingPage "9" @default.
- W2397767360 startingPage "524" @default.
- W2397767360 abstract "To evaluate the efficacy of one-week therapy with omeprazole, clarithromycin and amoxycillin in eradicating Helicobacter pylori and healing duodenal ulcer.One-hundred and thirty-four consecutive duodenal ulcer patients (mean age 47 +/- 13 yrs, 66% males) with H. pylori infection were prospectively studied. At endoscopy, biopsies from both gastric antrum and body were obtained for histologic study (H/E). A 15C-urea breath test was also performed in 98 patients. Omeprazole 20 mg b.i.d., amoxycillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. were administered only for 1 week, and no therapy was administered thereafter. Endoscopy with biopsies and breath test were repeated 1 month after completing therapy.Eradication was achieved in 87.3% of patients (n = 93; 95% CI = 82-93%). In the multivariate analysis the variables which influenced H. pylori eradication were: time of evolution of ulcer disease (p = 0.002) and active chronic gastritis in the antrum (p = 0.04) (chi 2 model = 15.8; p = 0.001). Ulcer healing was demonstrated in 89.5% of patients (84-95%), and healing rate was higher when eradication was achieved (94%; 90-98%) than in H. pylori-positive patients (59%; 36-78%) (p < 0.001). In the multivariate analysis the variables which influenced ulcer healing were: age (p = 0.02) and H. pylori eradication (p = 0.001) (chi 2 model = 21.2; p = 0.0001). An improvement of histologic gastritis was observed when eradication was achieved (p < 0.001). Compliance of therapy was complete in all patients but one and no relevant adverse effects were reported.One-week triple therapy with omeprazole, clarithromycin and amoxycillin administered on a twice daily basis achieves a high efficacy in eradicating H. pylori and healing duodenal ulcer. Moreover, this therapy regimen is simple and is associated with a low incidence of adverse effects and a low cost." @default.
- W2397767360 created "2016-06-24" @default.
- W2397767360 creator A5006803538 @default.
- W2397767360 creator A5014254734 @default.
- W2397767360 creator A5025425398 @default.
- W2397767360 creator A5039184033 @default.
- W2397767360 creator A5041791555 @default.
- W2397767360 creator A5075052827 @default.
- W2397767360 creator A5088075729 @default.
- W2397767360 creator A5088280306 @default.
- W2397767360 date "1997-04-12" @default.
- W2397767360 modified "2023-10-12" @default.
- W2397767360 title "[One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]." @default.
- W2397767360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9190436" @default.
- W2397767360 hasPublicationYear "1997" @default.
- W2397767360 type Work @default.
- W2397767360 sameAs 2397767360 @default.
- W2397767360 citedByCount "2" @default.
- W2397767360 crossrefType "journal-article" @default.
- W2397767360 hasAuthorship W2397767360A5006803538 @default.
- W2397767360 hasAuthorship W2397767360A5014254734 @default.
- W2397767360 hasAuthorship W2397767360A5025425398 @default.
- W2397767360 hasAuthorship W2397767360A5039184033 @default.
- W2397767360 hasAuthorship W2397767360A5041791555 @default.
- W2397767360 hasAuthorship W2397767360A5075052827 @default.
- W2397767360 hasAuthorship W2397767360A5088075729 @default.
- W2397767360 hasAuthorship W2397767360A5088280306 @default.
- W2397767360 hasConcept C126322002 @default.
- W2397767360 hasConcept C131253125 @default.
- W2397767360 hasConcept C2775981797 @default.
- W2397767360 hasConcept C2776409635 @default.
- W2397767360 hasConcept C2776962512 @default.
- W2397767360 hasConcept C2777172195 @default.
- W2397767360 hasConcept C2777498785 @default.
- W2397767360 hasConcept C2778451229 @default.
- W2397767360 hasConcept C2778677798 @default.
- W2397767360 hasConcept C2779422922 @default.
- W2397767360 hasConcept C2779708577 @default.
- W2397767360 hasConcept C2780708398 @default.
- W2397767360 hasConcept C2908868296 @default.
- W2397767360 hasConcept C501593827 @default.
- W2397767360 hasConcept C71924100 @default.
- W2397767360 hasConcept C86803240 @default.
- W2397767360 hasConcept C89423630 @default.
- W2397767360 hasConcept C90924648 @default.
- W2397767360 hasConceptScore W2397767360C126322002 @default.
- W2397767360 hasConceptScore W2397767360C131253125 @default.
- W2397767360 hasConceptScore W2397767360C2775981797 @default.
- W2397767360 hasConceptScore W2397767360C2776409635 @default.
- W2397767360 hasConceptScore W2397767360C2776962512 @default.
- W2397767360 hasConceptScore W2397767360C2777172195 @default.
- W2397767360 hasConceptScore W2397767360C2777498785 @default.
- W2397767360 hasConceptScore W2397767360C2778451229 @default.
- W2397767360 hasConceptScore W2397767360C2778677798 @default.
- W2397767360 hasConceptScore W2397767360C2779422922 @default.
- W2397767360 hasConceptScore W2397767360C2779708577 @default.
- W2397767360 hasConceptScore W2397767360C2780708398 @default.
- W2397767360 hasConceptScore W2397767360C2908868296 @default.
- W2397767360 hasConceptScore W2397767360C501593827 @default.
- W2397767360 hasConceptScore W2397767360C71924100 @default.
- W2397767360 hasConceptScore W2397767360C86803240 @default.
- W2397767360 hasConceptScore W2397767360C89423630 @default.
- W2397767360 hasConceptScore W2397767360C90924648 @default.
- W2397767360 hasIssue "14" @default.
- W2397767360 hasLocation W23977673601 @default.
- W2397767360 hasOpenAccess W2397767360 @default.
- W2397767360 hasPrimaryLocation W23977673601 @default.
- W2397767360 hasRelatedWork W1016986967 @default.
- W2397767360 hasRelatedWork W1969297582 @default.
- W2397767360 hasRelatedWork W2030251904 @default.
- W2397767360 hasRelatedWork W2045657923 @default.
- W2397767360 hasRelatedWork W2046112814 @default.
- W2397767360 hasRelatedWork W2139030568 @default.
- W2397767360 hasRelatedWork W2162337554 @default.
- W2397767360 hasRelatedWork W2341562468 @default.
- W2397767360 hasRelatedWork W2397767360 @default.
- W2397767360 hasRelatedWork W248670409 @default.
- W2397767360 hasVolume "108" @default.
- W2397767360 isParatext "false" @default.
- W2397767360 isRetracted "false" @default.
- W2397767360 magId "2397767360" @default.
- W2397767360 workType "article" @default.