Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397806876> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2397806876 endingPage "83" @default.
- W2397806876 startingPage "1577" @default.
- W2397806876 abstract "This study was aimed to investigate the effect of Honokiol (HNK) on proliferation and apoptosis of acute myeloid leukemia HL-60 cells and its potential mechanism. Inhibitory effect of HNK on the HL-60 cell proliferation was detected by MTT assay. Flow cytometry was used to detect the change of cell cycle and AnnexinV/PI staining was used to detect apoptosis. Western blot was applied to analyze the cell cycle protein (cyclins), cyclin-dependent kinase (CDK), P53, P21, P27, BCL-2, BCL-XL, Bax, caspase-3/9 and proteins for MAPK signal pathway. The results showed that HNK could inhibit the proliferation of HL-60 cells in time- and dose dependent ways. HNK arrested HL-60 cells in G0/G1 phase, and S phase cells decreased significantly (P < 0.05). The expression of cyclin D1, cyclin A, cyclin E and CDK2/4/6 were significantly down-regulated (P < 0.05), the expression of P53 and P21 was significantly upregulated after treating for 24 h with HNK (P < 0.05). After 24 h treatment with HNK, HL-60 cell apoptosis increased significantly with the upregulation of activated caspase-3, -9, BAX expression and the downregulation of BCL-2, BCL-XL expression. The MAPK subfamily, P38 and JNK were not significantly changed, but the expression of MEK1/2-ERK1/2 was significantly downregulated (P < 0.05). It is concluded that HNK arrestes the cells at G0/G1 phase and induces HL-60 cell apoptosis through the intervention of MEK1/2-ERK1/2 signaling pathway." @default.
- W2397806876 created "2016-06-24" @default.
- W2397806876 creator A5009336243 @default.
- W2397806876 creator A5029279163 @default.
- W2397806876 creator A5033097876 @default.
- W2397806876 creator A5037068166 @default.
- W2397806876 creator A5053512370 @default.
- W2397806876 creator A5073941581 @default.
- W2397806876 creator A5074012582 @default.
- W2397806876 creator A5078555655 @default.
- W2397806876 date "2014-12-01" @default.
- W2397806876 modified "2023-09-26" @default.
- W2397806876 title "[Effect of honokiol on proliferation and apoptosis in HL-60 cells and its potential mechanism]." @default.
- W2397806876 doi "https://doi.org/10.7534/j.issn.1009-2137.2014.06.015" @default.
- W2397806876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25543478" @default.
- W2397806876 hasPublicationYear "2014" @default.
- W2397806876 type Work @default.
- W2397806876 sameAs 2397806876 @default.
- W2397806876 citedByCount "0" @default.
- W2397806876 crossrefType "journal-article" @default.
- W2397806876 hasAuthorship W2397806876A5009336243 @default.
- W2397806876 hasAuthorship W2397806876A5029279163 @default.
- W2397806876 hasAuthorship W2397806876A5033097876 @default.
- W2397806876 hasAuthorship W2397806876A5037068166 @default.
- W2397806876 hasAuthorship W2397806876A5053512370 @default.
- W2397806876 hasAuthorship W2397806876A5073941581 @default.
- W2397806876 hasAuthorship W2397806876A5074012582 @default.
- W2397806876 hasAuthorship W2397806876A5078555655 @default.
- W2397806876 hasConcept C104317684 @default.
- W2397806876 hasConcept C124320809 @default.
- W2397806876 hasConcept C127561419 @default.
- W2397806876 hasConcept C153911025 @default.
- W2397806876 hasConcept C16438837 @default.
- W2397806876 hasConcept C184235292 @default.
- W2397806876 hasConcept C185592680 @default.
- W2397806876 hasConcept C190283241 @default.
- W2397806876 hasConcept C199835354 @default.
- W2397806876 hasConcept C29537977 @default.
- W2397806876 hasConcept C502942594 @default.
- W2397806876 hasConcept C55493867 @default.
- W2397806876 hasConcept C57074206 @default.
- W2397806876 hasConcept C62112901 @default.
- W2397806876 hasConcept C82495950 @default.
- W2397806876 hasConcept C86803240 @default.
- W2397806876 hasConcept C94561458 @default.
- W2397806876 hasConcept C95444343 @default.
- W2397806876 hasConceptScore W2397806876C104317684 @default.
- W2397806876 hasConceptScore W2397806876C124320809 @default.
- W2397806876 hasConceptScore W2397806876C127561419 @default.
- W2397806876 hasConceptScore W2397806876C153911025 @default.
- W2397806876 hasConceptScore W2397806876C16438837 @default.
- W2397806876 hasConceptScore W2397806876C184235292 @default.
- W2397806876 hasConceptScore W2397806876C185592680 @default.
- W2397806876 hasConceptScore W2397806876C190283241 @default.
- W2397806876 hasConceptScore W2397806876C199835354 @default.
- W2397806876 hasConceptScore W2397806876C29537977 @default.
- W2397806876 hasConceptScore W2397806876C502942594 @default.
- W2397806876 hasConceptScore W2397806876C55493867 @default.
- W2397806876 hasConceptScore W2397806876C57074206 @default.
- W2397806876 hasConceptScore W2397806876C62112901 @default.
- W2397806876 hasConceptScore W2397806876C82495950 @default.
- W2397806876 hasConceptScore W2397806876C86803240 @default.
- W2397806876 hasConceptScore W2397806876C94561458 @default.
- W2397806876 hasConceptScore W2397806876C95444343 @default.
- W2397806876 hasIssue "6" @default.
- W2397806876 hasLocation W23978068761 @default.
- W2397806876 hasOpenAccess W2397806876 @default.
- W2397806876 hasPrimaryLocation W23978068761 @default.
- W2397806876 hasRelatedWork W1985544840 @default.
- W2397806876 hasRelatedWork W1990593021 @default.
- W2397806876 hasRelatedWork W2000483549 @default.
- W2397806876 hasRelatedWork W2048642058 @default.
- W2397806876 hasRelatedWork W2053827948 @default.
- W2397806876 hasRelatedWork W2063667483 @default.
- W2397806876 hasRelatedWork W2086579701 @default.
- W2397806876 hasRelatedWork W2322711897 @default.
- W2397806876 hasRelatedWork W2408878688 @default.
- W2397806876 hasRelatedWork W297761204 @default.
- W2397806876 hasVolume "22" @default.
- W2397806876 isParatext "false" @default.
- W2397806876 isRetracted "false" @default.
- W2397806876 magId "2397806876" @default.
- W2397806876 workType "article" @default.