Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397867665> ?p ?o ?g. }
- W2397867665 endingPage "1663" @default.
- W2397867665 startingPage "1663" @default.
- W2397867665 abstract "Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury Yanzhe Wang, Zhiyi He, Shumin Deng Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China Background: Activators of PPARs, particularly PPARγ, may be effective neuroprotective drugs against inflammatory responses in cerebral ischemia and reperfusion injury. Ursolic acid (UA) may act as a PPARγ agonist and serve as an anti-inflammatory agent. In this study, we used a rat middle cerebral artery occlusion and reperfusion model to examine how UA acts as a neuroprotective agent to modulate the metalloprotease/anti-metalloprotease balance. Methods: The middle cerebral artery occlusion and reperfusion model (occlusion for 2 hours followed by reperfusion for 48 hours) was induced in male Sprague Dawley rats. UA was administered intragastrically 0.5, 24, and 47 hours after reperfusion. Bisphenol A diglycidyl ether (a PPARγ antagonist) was intraperitoneally administered 1, 24.5, and 47.5 hours after reperfusion. Forty-eight hours after reperfusion, neurological deficits and infarct volume were estimated. The PPARγ level and the metalloprotease/anti-metalloprotease balance were examined by Western blotting and immunohistochemistry. The activation of MAPK signaling pathways was also assessed. Results: UA-treated (5, 10, or 20 mg/kg) rats showed significant improvement in neurological deficit score, infarct volume, and the number of intact neurons compared with control rats (P" @default.
- W2397867665 created "2016-06-24" @default.
- W2397867665 creator A5034133337 @default.
- W2397867665 creator A5048732806 @default.
- W2397867665 creator A5081581951 @default.
- W2397867665 date "2016-05-01" @default.
- W2397867665 modified "2023-09-26" @default.
- W2397867665 title "Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury" @default.
- W2397867665 cites W1540258377 @default.
- W2397867665 cites W1937277400 @default.
- W2397867665 cites W1942299774 @default.
- W2397867665 cites W1974766546 @default.
- W2397867665 cites W1975296850 @default.
- W2397867665 cites W1979807853 @default.
- W2397867665 cites W1984715375 @default.
- W2397867665 cites W1988978162 @default.
- W2397867665 cites W1996328429 @default.
- W2397867665 cites W1998267950 @default.
- W2397867665 cites W2002156365 @default.
- W2397867665 cites W2002175587 @default.
- W2397867665 cites W2009233043 @default.
- W2397867665 cites W2022219828 @default.
- W2397867665 cites W2028517578 @default.
- W2397867665 cites W2036056289 @default.
- W2397867665 cites W2047793512 @default.
- W2397867665 cites W2048047884 @default.
- W2397867665 cites W2052203283 @default.
- W2397867665 cites W2060393372 @default.
- W2397867665 cites W2062138468 @default.
- W2397867665 cites W2071528876 @default.
- W2397867665 cites W2081047269 @default.
- W2397867665 cites W2085515185 @default.
- W2397867665 cites W2089492785 @default.
- W2397867665 cites W2096545764 @default.
- W2397867665 cites W2102998091 @default.
- W2397867665 cites W2108790161 @default.
- W2397867665 cites W2112505121 @default.
- W2397867665 cites W2125683177 @default.
- W2397867665 cites W2139645648 @default.
- W2397867665 cites W2147150250 @default.
- W2397867665 cites W2149287982 @default.
- W2397867665 cites W2154928040 @default.
- W2397867665 cites W2155277431 @default.
- W2397867665 cites W2156371985 @default.
- W2397867665 cites W2156645547 @default.
- W2397867665 cites W2158502209 @default.
- W2397867665 cites W2312687934 @default.
- W2397867665 cites W2322394345 @default.
- W2397867665 cites W2328903040 @default.
- W2397867665 cites W2334019335 @default.
- W2397867665 cites W2371948111 @default.
- W2397867665 doi "https://doi.org/10.2147/dddt.s103829" @default.
- W2397867665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4876798" @default.
- W2397867665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27274199" @default.
- W2397867665 hasPublicationYear "2016" @default.
- W2397867665 type Work @default.
- W2397867665 sameAs 2397867665 @default.
- W2397867665 citedByCount "33" @default.
- W2397867665 countsByYear W23978676652017 @default.
- W2397867665 countsByYear W23978676652018 @default.
- W2397867665 countsByYear W23978676652019 @default.
- W2397867665 countsByYear W23978676652020 @default.
- W2397867665 countsByYear W23978676652021 @default.
- W2397867665 countsByYear W23978676652022 @default.
- W2397867665 countsByYear W23978676652023 @default.
- W2397867665 crossrefType "journal-article" @default.
- W2397867665 hasAuthorship W2397867665A5034133337 @default.
- W2397867665 hasAuthorship W2397867665A5048732806 @default.
- W2397867665 hasAuthorship W2397867665A5081581951 @default.
- W2397867665 hasBestOaLocation W23978676651 @default.
- W2397867665 hasConcept C109523444 @default.
- W2397867665 hasConcept C126322002 @default.
- W2397867665 hasConcept C170493617 @default.
- W2397867665 hasConcept C185592680 @default.
- W2397867665 hasConcept C25498285 @default.
- W2397867665 hasConcept C2778938600 @default.
- W2397867665 hasConcept C2779513101 @default.
- W2397867665 hasConcept C2780114680 @default.
- W2397867665 hasConcept C42219234 @default.
- W2397867665 hasConcept C43617362 @default.
- W2397867665 hasConcept C541997718 @default.
- W2397867665 hasConcept C55728118 @default.
- W2397867665 hasConcept C71924100 @default.
- W2397867665 hasConcept C98274493 @default.
- W2397867665 hasConceptScore W2397867665C109523444 @default.
- W2397867665 hasConceptScore W2397867665C126322002 @default.
- W2397867665 hasConceptScore W2397867665C170493617 @default.
- W2397867665 hasConceptScore W2397867665C185592680 @default.
- W2397867665 hasConceptScore W2397867665C25498285 @default.
- W2397867665 hasConceptScore W2397867665C2778938600 @default.
- W2397867665 hasConceptScore W2397867665C2779513101 @default.
- W2397867665 hasConceptScore W2397867665C2780114680 @default.
- W2397867665 hasConceptScore W2397867665C42219234 @default.
- W2397867665 hasConceptScore W2397867665C43617362 @default.
- W2397867665 hasConceptScore W2397867665C541997718 @default.
- W2397867665 hasConceptScore W2397867665C55728118 @default.
- W2397867665 hasConceptScore W2397867665C71924100 @default.
- W2397867665 hasConceptScore W2397867665C98274493 @default.