Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397923369> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2397923369 endingPage "487" @default.
- W2397923369 startingPage "477" @default.
- W2397923369 abstract "Detailed characterization of the tumor vasculature provides a better understanding of the complex mechanisms associated with tumor development and is especially important to evaluate responses to current therapies which target the tumor vasculature. Magnetic resonance imaging (MRI) studies of tumors have been mostly performed using gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) contrast-enhanced imaging, which relies on Gd-DTPA leakage from hyperpermeable tumor vessels and subsequent accumulation in the tumor interstitium. In certain tumor types, especially diffuse glioma in the brain, incorporated tumor vessels are not necessarily leaky, complicating effective diagnosis via Gd-DTPA contrast-enhanced MRI. Another class of contrast agents, based on superparamagnetic ultrasmall iron oxide particles (USPIO), allows for non-invasive assessment of vascular volume within the tumor. Vascular volume can be obtained by calculating the change in water proton transverse relaxation rate (R (2) or R (2)) following USPIO administration. This allows for an objective comparison between vascular volumes of different tumors and also allows to perform longitudinal studies in order to assess, for example, treatment efficacy. Moreover, since the USPIO T (2) relaxivity is up to 20 times that of Gd-DTPA, USPIO provides a highly sensitive marker for alterations in vascular volume among tissues; this characteristic might be exploited for tumor detection. Thus, USPIO imaging may be a very attractive alternative to the most commonly used Gd-DTPA imaging and will at least have added value, especially for detection and delineation of diffuse infiltrative brain tumors." @default.
- W2397923369 created "2016-06-24" @default.
- W2397923369 creator A5003400443 @default.
- W2397923369 creator A5019822912 @default.
- W2397923369 date "2011-01-01" @default.
- W2397923369 modified "2023-09-26" @default.
- W2397923369 title "Characterization of Tumor Vasculature in Mouse Brain by USPIO Contrast-Enhanced MRI" @default.
- W2397923369 cites W1970124993 @default.
- W2397923369 cites W1983569280 @default.
- W2397923369 cites W2004144303 @default.
- W2397923369 cites W2011272082 @default.
- W2397923369 cites W2012469554 @default.
- W2397923369 cites W2018051866 @default.
- W2397923369 cites W2068963958 @default.
- W2397923369 cites W2071252762 @default.
- W2397923369 cites W2079716456 @default.
- W2397923369 cites W2099087398 @default.
- W2397923369 cites W2141851994 @default.
- W2397923369 cites W2142699556 @default.
- W2397923369 cites W2146123518 @default.
- W2397923369 cites W2157036804 @default.
- W2397923369 doi "https://doi.org/10.1007/978-1-61779-219-9_25" @default.
- W2397923369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21874494" @default.
- W2397923369 hasPublicationYear "2011" @default.
- W2397923369 type Work @default.
- W2397923369 sameAs 2397923369 @default.
- W2397923369 citedByCount "7" @default.
- W2397923369 countsByYear W23979233692014 @default.
- W2397923369 countsByYear W23979233692016 @default.
- W2397923369 countsByYear W23979233692019 @default.
- W2397923369 countsByYear W23979233692022 @default.
- W2397923369 crossrefType "book-chapter" @default.
- W2397923369 hasAuthorship W2397923369A5003400443 @default.
- W2397923369 hasAuthorship W2397923369A5019822912 @default.
- W2397923369 hasConcept C126838900 @default.
- W2397923369 hasConcept C142724271 @default.
- W2397923369 hasConcept C143409427 @default.
- W2397923369 hasConcept C178790620 @default.
- W2397923369 hasConcept C185592680 @default.
- W2397923369 hasConcept C2778227246 @default.
- W2397923369 hasConcept C2779130545 @default.
- W2397923369 hasConcept C502942594 @default.
- W2397923369 hasConcept C557651011 @default.
- W2397923369 hasConcept C71924100 @default.
- W2397923369 hasConceptScore W2397923369C126838900 @default.
- W2397923369 hasConceptScore W2397923369C142724271 @default.
- W2397923369 hasConceptScore W2397923369C143409427 @default.
- W2397923369 hasConceptScore W2397923369C178790620 @default.
- W2397923369 hasConceptScore W2397923369C185592680 @default.
- W2397923369 hasConceptScore W2397923369C2778227246 @default.
- W2397923369 hasConceptScore W2397923369C2779130545 @default.
- W2397923369 hasConceptScore W2397923369C502942594 @default.
- W2397923369 hasConceptScore W2397923369C557651011 @default.
- W2397923369 hasConceptScore W2397923369C71924100 @default.
- W2397923369 hasLocation W23979233691 @default.
- W2397923369 hasLocation W23979233692 @default.
- W2397923369 hasOpenAccess W2397923369 @default.
- W2397923369 hasPrimaryLocation W23979233691 @default.
- W2397923369 hasRelatedWork W1983225948 @default.
- W2397923369 hasRelatedWork W1993471519 @default.
- W2397923369 hasRelatedWork W2029943263 @default.
- W2397923369 hasRelatedWork W2065042263 @default.
- W2397923369 hasRelatedWork W2150012525 @default.
- W2397923369 hasRelatedWork W2357214907 @default.
- W2397923369 hasRelatedWork W2374437316 @default.
- W2397923369 hasRelatedWork W2381365023 @default.
- W2397923369 hasRelatedWork W2480453571 @default.
- W2397923369 hasRelatedWork W2981892420 @default.
- W2397923369 isParatext "false" @default.
- W2397923369 isRetracted "false" @default.
- W2397923369 magId "2397923369" @default.
- W2397923369 workType "book-chapter" @default.