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- W2397924138 abstract "In order to investigate adverse effects of herbal drugs, we performed toxicological studies on the methanolic extract from Moutan bark (botanpi) and on the aqueous extracts from Glycyrrhiza (kanzou) and Bupleurum root (saiko) in rats and mice. In the single administration study, these extracts were given orally or intraperitoneally to male Wistar rats and ddY mice at a dose of 6g/kg, and acute toxic effects of the extracts were investigated. In the repeated administration study, these extracts were given orally by intubation to male Wistar rats once a day for 21d at daily doses of 1.5g/kg and 3g/kg. General appearance and body weight of the rats were checked daily, and behavioral, hematological, biochemical and pathological examinations were performed. The results obtained are as follows.1) Single administration studMoutan bark, Glycyrrhiza and Bupleurum root did not show any toxic effect in rats and mice by an oral administration, whereas these herbal drugs showed potent toxic effects by an intraperitoneal injection. No species difference in the toxic effects of these herbal drugs was found between the rat and mouse.2) Repeated administration studyMoutan bark: The erythrocyte count, hemoglobin level and hematocrit value in the blood decreased, the total bilirubin level in the serum increased, and a moderate deposition of hemosiderin in the spleen was evidenced in the pathological observation. These results indicate a weak hemolytic effect of Moutan bark, though no abnormal changes in the size, shape and osmotic fragility of the erythrocytes were found. And also, increases in the liver ALP, GPDAP and LAP activities indicate the possibility of weak influence of Moutan bark on the liver function.Glycyrrhiza: Increases in the kidney weight and urinary protein level and an induction of the renal drug metabolizing enzyme system indicate the possibility of weak influence of Glycyrrhiza on the renal function. The erythrocyte count and hematocrit value decreased slightly.Bupleurum root: The erythrocyte count decreased slightly. The liver weight and the serum γ-GTP activity increased slightly.It is considered that these results should be useful for the safety evaluation of the herbal drugs for human use." @default.
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- W2397924138 date "1986-01-01" @default.
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- W2397924138 title "Toxicological Studies on Biological Effects of the Herbal Drug Extracts in Rats and Mice. II" @default.
- W2397924138 doi "https://doi.org/10.1248/yakushi1947.106.8_671" @default.
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