Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397947183> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2397947183 endingPage "198" @default.
- W2397947183 startingPage "190" @default.
- W2397947183 abstract "Purpose of the Study: This study investigated whether sarpogrelate hydrochloride (SPG), a 5-HT2A receptor antagonist, alleviates chronic hypoxic pulmonary hypertension (CH-PH) in rats by stimulating apoptosis and inhibiting proliferation in pulmonary artery smooth muscle cells (PASMCs). Materials and Methods: Forty male Sprague-Dawley rats were pretreated with SPG (50 mg/kg/day by oral gavage) or saline vehicle and then subjected to chronic hypoxia (CH) (hypobaric chamber set to 380 mmHg, 10% oxygen) or normoxia for 14 days. Mean pulmonary artery pressure (PAP) and right ventricular hypertrophy (RVH) were measured. Hypertensive pulmonary vascular remodeling was assayed by light microscopy. Terminal deoxynucletidyl transferase dUTP nick end ligase (TUNEL) assays, western blotting, and real-time polymerase chain reaction were used to assess apoptosis, proliferation and underlying signaling pathways in PASMCs from lung tissue and isolated pulmonary artery rings. Results: CH increased mean PAP and RVH. CH increased the percentage of muscularized arteries in the peripheral pulmonary vasculature and medial wall thickness in small muscular arteries. CH increased pulmonary protein and mRNA levels of the B-cell lymphoma protein 2 (Bcl-2), pyruvate dehydrogenase kinase (PDK), phosphorylation of extracellular signal-regulated kinases 1 and 2 (pERK1/2), cyclin D1, proliferating cell nuclear antigen (PCNA) and decreased protein and mRNA levels of Bcl-2-associated X protein (BAX), cleaved caspase-3. Pretreatment with SPG, which has been shown previously to inhibit ERK1/2 phosphorylation and PDK, countered all of these effects. Isolated pulmonary artery rings incubated with 5-HT increased pERK1/2, PDK, and Bcl-2 expression, and decreased Bax expression. Conclusion: Administration of SPG ameliorated the development of CH-PH by stimulating apoptosis in and inhibiting proliferation of PASMCs." @default.
- W2397947183 created "2016-06-24" @default.
- W2397947183 creator A5002398771 @default.
- W2397947183 creator A5008034207 @default.
- W2397947183 creator A5019224827 @default.
- W2397947183 creator A5040120585 @default.
- W2397947183 creator A5060448158 @default.
- W2397947183 creator A5064642018 @default.
- W2397947183 creator A5074461924 @default.
- W2397947183 creator A5085098106 @default.
- W2397947183 creator A5086559201 @default.
- W2397947183 creator A5087854367 @default.
- W2397947183 date "2016-04-20" @default.
- W2397947183 modified "2023-10-18" @default.
- W2397947183 title "The effects of the 5-HT2Areceptor antagonist sarpogrelate hydrochloride on chronic hypoxic pulmonary hypertension in rats" @default.
- W2397947183 cites W1974049103 @default.
- W2397947183 cites W1998223482 @default.
- W2397947183 cites W2000626196 @default.
- W2397947183 cites W2040102869 @default.
- W2397947183 cites W2044684848 @default.
- W2397947183 cites W2065819294 @default.
- W2397947183 cites W2067671329 @default.
- W2397947183 cites W2087393559 @default.
- W2397947183 cites W2092702897 @default.
- W2397947183 cites W2105963888 @default.
- W2397947183 cites W2131031641 @default.
- W2397947183 cites W2146730628 @default.
- W2397947183 cites W2165788804 @default.
- W2397947183 cites W2170004689 @default.
- W2397947183 cites W4251161234 @default.
- W2397947183 cites W4293257851 @default.
- W2397947183 cites W2067783040 @default.
- W2397947183 doi "https://doi.org/10.1080/01902148.2016.1181122" @default.
- W2397947183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27191897" @default.
- W2397947183 hasPublicationYear "2016" @default.
- W2397947183 type Work @default.
- W2397947183 sameAs 2397947183 @default.
- W2397947183 citedByCount "3" @default.
- W2397947183 countsByYear W23979471832017 @default.
- W2397947183 countsByYear W23979471832018 @default.
- W2397947183 crossrefType "journal-article" @default.
- W2397947183 hasAuthorship W2397947183A5002398771 @default.
- W2397947183 hasAuthorship W2397947183A5008034207 @default.
- W2397947183 hasAuthorship W2397947183A5019224827 @default.
- W2397947183 hasAuthorship W2397947183A5040120585 @default.
- W2397947183 hasAuthorship W2397947183A5060448158 @default.
- W2397947183 hasAuthorship W2397947183A5064642018 @default.
- W2397947183 hasAuthorship W2397947183A5074461924 @default.
- W2397947183 hasAuthorship W2397947183A5085098106 @default.
- W2397947183 hasAuthorship W2397947183A5086559201 @default.
- W2397947183 hasAuthorship W2397947183A5087854367 @default.
- W2397947183 hasConcept C126322002 @default.
- W2397947183 hasConcept C134018914 @default.
- W2397947183 hasConcept C184235292 @default.
- W2397947183 hasConcept C190283241 @default.
- W2397947183 hasConcept C196795494 @default.
- W2397947183 hasConcept C204232928 @default.
- W2397947183 hasConcept C2779376020 @default.
- W2397947183 hasConcept C2780930700 @default.
- W2397947183 hasConcept C2780940725 @default.
- W2397947183 hasConcept C34688535 @default.
- W2397947183 hasConcept C55493867 @default.
- W2397947183 hasConcept C71924100 @default.
- W2397947183 hasConcept C86803240 @default.
- W2397947183 hasConceptScore W2397947183C126322002 @default.
- W2397947183 hasConceptScore W2397947183C134018914 @default.
- W2397947183 hasConceptScore W2397947183C184235292 @default.
- W2397947183 hasConceptScore W2397947183C190283241 @default.
- W2397947183 hasConceptScore W2397947183C196795494 @default.
- W2397947183 hasConceptScore W2397947183C204232928 @default.
- W2397947183 hasConceptScore W2397947183C2779376020 @default.
- W2397947183 hasConceptScore W2397947183C2780930700 @default.
- W2397947183 hasConceptScore W2397947183C2780940725 @default.
- W2397947183 hasConceptScore W2397947183C34688535 @default.
- W2397947183 hasConceptScore W2397947183C55493867 @default.
- W2397947183 hasConceptScore W2397947183C71924100 @default.
- W2397947183 hasConceptScore W2397947183C86803240 @default.
- W2397947183 hasIssue "4" @default.
- W2397947183 hasLocation W23979471831 @default.
- W2397947183 hasLocation W23979471832 @default.
- W2397947183 hasOpenAccess W2397947183 @default.
- W2397947183 hasPrimaryLocation W23979471831 @default.
- W2397947183 hasRelatedWork W12585302 @default.
- W2397947183 hasRelatedWork W2267065393 @default.
- W2397947183 hasRelatedWork W2360419530 @default.
- W2397947183 hasRelatedWork W2364785322 @default.
- W2397947183 hasRelatedWork W2369053899 @default.
- W2397947183 hasRelatedWork W2378949748 @default.
- W2397947183 hasRelatedWork W2382704315 @default.
- W2397947183 hasRelatedWork W2384056888 @default.
- W2397947183 hasRelatedWork W2389644326 @default.
- W2397947183 hasRelatedWork W2390310201 @default.
- W2397947183 hasVolume "42" @default.
- W2397947183 isParatext "false" @default.
- W2397947183 isRetracted "false" @default.
- W2397947183 magId "2397947183" @default.
- W2397947183 workType "article" @default.