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- W2397947765 abstract "Hepatitis C virus (HCV) remains a public health problem of global importance, even in the era of potent directly-acting antiviral drugs. In this chapter, I discuss immune responses to acute and chronic HCV infection. The outcome of HCV infection is influenced by viral strategies that limit or delay the initiation of innate antiviral responses. This delay may enable HCV to establish widespread infection long before the host mounts effective T and B cell responses. HCV's genetic agility, resulting from its high rate of replication and its error prone replication mechanism, enables it to evade immune recognition. Adaptive immune responses fail to keep up with changing viral epitopes. Neutralizing antibody epitopes may be hidden by decoy structures, glycans, and lipoproteins. T cell responses fail due to changing epitope sequences and due to exhaustion, a phenomenon that may have evolved to limit immune-mediated pathology. Despite these difficulties, innate and adaptive immune mechanisms do impact HCV replication. Immune-mediated clearance of infection is possible, occurring in 20-50% of people who contract the disease. New developments raise hopes for effective immunological interventions to prevent or treat HCV infection." @default.
- W2397947765 created "2016-06-24" @default.
- W2397947765 creator A5031987345 @default.
- W2397947765 date "2017-04-28" @default.
- W2397947765 modified "2023-10-17" @default.
- W2397947765 title "Innate and Adaptive Immune Responses in Chronic HCV Infection" @default.
- W2397947765 cites W1505139021 @default.
- W2397947765 cites W1516535702 @default.
- W2397947765 cites W1519268009 @default.
- W2397947765 cites W1528432054 @default.
- W2397947765 cites W1528826985 @default.
- W2397947765 cites W1554290496 @default.
- W2397947765 cites W1569603086 @default.
- W2397947765 cites W1585906932 @default.
- W2397947765 cites W160108744 @default.
- W2397947765 cites W1781851127 @default.
- W2397947765 cites W1881009043 @default.
- W2397947765 cites W1942926563 @default.
- W2397947765 cites W1964790913 @default.
- W2397947765 cites W1965776393 @default.
- W2397947765 cites W1966153332 @default.
- W2397947765 cites W1967491261 @default.
- W2397947765 cites W1969720994 @default.
- W2397947765 cites W1970276280 @default.
- W2397947765 cites W1970347634 @default.
- W2397947765 cites W1971241973 @default.
- W2397947765 cites W1972503143 @default.
- W2397947765 cites W1974021931 @default.
- W2397947765 cites W1974593063 @default.
- W2397947765 cites W1975576681 @default.
- W2397947765 cites W1975753196 @default.
- W2397947765 cites W1975848200 @default.
- W2397947765 cites W1977300462 @default.
- W2397947765 cites W1977426839 @default.
- W2397947765 cites W1978916431 @default.
- W2397947765 cites W1979999592 @default.
- W2397947765 cites W1981009477 @default.
- W2397947765 cites W1981136135 @default.
- W2397947765 cites W1982514203 @default.
- W2397947765 cites W1983695417 @default.
- W2397947765 cites W1984587729 @default.
- W2397947765 cites W1985982900 @default.
- W2397947765 cites W1986551392 @default.
- W2397947765 cites W1986616881 @default.
- W2397947765 cites W1986944906 @default.
- W2397947765 cites W1990058709 @default.
- W2397947765 cites W1991893044 @default.
- W2397947765 cites W1992004393 @default.
- W2397947765 cites W1992541741 @default.
- W2397947765 cites W1992603628 @default.
- W2397947765 cites W1993023565 @default.
- W2397947765 cites W1993271293 @default.
- W2397947765 cites W1995824993 @default.
- W2397947765 cites W1996053108 @default.
- W2397947765 cites W1996295206 @default.
- W2397947765 cites W1997876081 @default.
- W2397947765 cites W1998373476 @default.
- W2397947765 cites W2000782434 @default.
- W2397947765 cites W2000835793 @default.
- W2397947765 cites W2001331132 @default.
- W2397947765 cites W2001444622 @default.
- W2397947765 cites W2001558817 @default.
- W2397947765 cites W2001624137 @default.
- W2397947765 cites W2001800161 @default.
- W2397947765 cites W2004651002 @default.
- W2397947765 cites W2005113160 @default.
- W2397947765 cites W2007013372 @default.
- W2397947765 cites W2007509612 @default.
- W2397947765 cites W2008860633 @default.
- W2397947765 cites W2011552383 @default.
- W2397947765 cites W2012180137 @default.
- W2397947765 cites W2012873002 @default.
- W2397947765 cites W2013092102 @default.
- W2397947765 cites W2013150240 @default.
- W2397947765 cites W2013607338 @default.
- W2397947765 cites W2013859348 @default.
- W2397947765 cites W2014290325 @default.
- W2397947765 cites W2014828596 @default.
- W2397947765 cites W2014957742 @default.
- W2397947765 cites W2015878390 @default.
- W2397947765 cites W2016005973 @default.
- W2397947765 cites W2016081852 @default.
- W2397947765 cites W2016616640 @default.
- W2397947765 cites W2016878095 @default.
- W2397947765 cites W2017013905 @default.
- W2397947765 cites W2017359325 @default.
- W2397947765 cites W2018882959 @default.
- W2397947765 cites W2019799886 @default.
- W2397947765 cites W2019864920 @default.
- W2397947765 cites W2020301780 @default.
- W2397947765 cites W2020516948 @default.
- W2397947765 cites W2021199098 @default.
- W2397947765 cites W2021668929 @default.
- W2397947765 cites W2021736493 @default.
- W2397947765 cites W2022077416 @default.
- W2397947765 cites W2022687771 @default.
- W2397947765 cites W2024692673 @default.
- W2397947765 cites W2024763248 @default.