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• W2397948863 abstract "Abstract Background D anggui B uxue T ang (DBT), a Chinese herbal decoction containing A stragali R adix (AR; roots of Astragalus memebranaceus (Fisch.) Bunge var. mongholicus (Bunge) Hsiao) and A ngelicae S inensis R adix (ASR; roots of Angelica sinensis Oliv.) at a weight ratio of 5:1, is used to improve menopausal syndromes in women. Several lines of evidence indicate that DBT has strong estrogenic property; however, the action mechanism of this herbal decoction is not known. Calycosin, a major flavonoid in AR, shares similar structure with β-estradiol, and thus which is hypothesized to be the key compound of DBT in responsible for such estrogenic properties. Aims We aimed to determine the role of calycosin in DBT in terms of its estrogenic functions by the creation of calycosin-depleted DBT (DBT Δcal ) and calycosin-added DBT (DBT +cal ) herbal extracts. Methods The signalings triggered by DBT ∆cal , DBT +cal , and parental DBT were compared in cultured MCF-7 cells by determining: (i) the activation of estrogen responsive element; (ii) the phosphorylation of estrogen receptor α (ERα); and (iii) the phosphorylation of Erk1/2. The DBT-induced responses were in dose- and/or time-dependent manners. Results The estrogenic signals triggered by DBT were markedly reduced in DBT Δcal , and in contrast the addition of calycosin in DBT, i.e. DBT +cal , enhanced the responses by 2–5 folds; however, calycosin alone did not show such properties. In parallel, the DBT-induced responses could be significantly blocked by inhibitors for estrogen receptor and mitogen activated protein kinases. Conclusion Thus, we hypothesize that calycosin is an indispensable chemical in DBT, and which plays a linker in orchestrating multi-components of DBT as to achieve the maximal estrogenic functions. These discoveries should be invaluable in drug development and in investigating the modernization of traditional Chinese medicine from a new perspective." @default.
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• W2397948863 date "2016-08-01" @default.
• W2397948863 modified "2023-10-10" @default.
• W2397948863 title "The estrogenic properties of Danggui Buxue Tang, a Chinese herbal decoction, are triggered predominantly by calycosin in MCF-7 cells" @default.
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• W2397948863 doi "https://doi.org/10.1016/j.jep.2016.05.035" @default.
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