Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397973103> ?p ?o ?g. }
- W2397973103 endingPage "297" @default.
- W2397973103 startingPage "292" @default.
- W2397973103 abstract "The concurrent management of type 2 diabetes mellitus (T2DM) and chronic congestive heart failure presents several therapeutic challenges. Of concern is that insulin and insulin-sensitizing medications detrimentally flood the heart with energy-providing substrates, including fats and glucose. In this population, treatment of T2DM should focus on the reduction of increased substrate supply. Sodium glucose cotransporter-2 (SGLT-2) inhibitors, a new class of antidiabetic medication, operate via this principle by blocking the reabsorption of glucose in the kidney and subsequently releasing glucose through the urine. In this review, we begin with an examination of the mechanisms of glucotoxicity and lipotoxicity in the heart. Then we analyze the potential role of SGLT-2 inhibitor therapy in patients with concurrent T2DM and chronic heart failure. Based on the available evidence, SGLT-2 inhibitors are safe and can be recommended to treat T2DM in patients with chronic heart failure and intact renal function. Further studies are in progress to assess long-term survival benefits." @default.
- W2397973103 created "2016-06-24" @default.
- W2397973103 creator A5010780253 @default.
- W2397973103 creator A5010975035 @default.
- W2397973103 creator A5030529424 @default.
- W2397973103 creator A5043064282 @default.
- W2397973103 date "2015-09-01" @default.
- W2397973103 modified "2023-10-16" @default.
- W2397973103 title "The Use of SGLT-2 Inhibitors in Type 2 Diabetes and Heart Failure" @default.
- W2397973103 cites W1497671643 @default.
- W2397973103 cites W1543261695 @default.
- W2397973103 cites W1968715224 @default.
- W2397973103 cites W1977810453 @default.
- W2397973103 cites W1983133936 @default.
- W2397973103 cites W1987015387 @default.
- W2397973103 cites W1998877815 @default.
- W2397973103 cites W2009666209 @default.
- W2397973103 cites W2012085370 @default.
- W2397973103 cites W2013109740 @default.
- W2397973103 cites W2016103822 @default.
- W2397973103 cites W2018903719 @default.
- W2397973103 cites W2021517048 @default.
- W2397973103 cites W2024144792 @default.
- W2397973103 cites W2024878386 @default.
- W2397973103 cites W2025557298 @default.
- W2397973103 cites W2026199993 @default.
- W2397973103 cites W2027519369 @default.
- W2397973103 cites W2030311010 @default.
- W2397973103 cites W2035626188 @default.
- W2397973103 cites W2035704925 @default.
- W2397973103 cites W2036127635 @default.
- W2397973103 cites W2044474225 @default.
- W2397973103 cites W2046345048 @default.
- W2397973103 cites W2049697163 @default.
- W2397973103 cites W2052503411 @default.
- W2397973103 cites W2058536977 @default.
- W2397973103 cites W2071010185 @default.
- W2397973103 cites W2072040765 @default.
- W2397973103 cites W2072535229 @default.
- W2397973103 cites W2074610906 @default.
- W2397973103 cites W2077636750 @default.
- W2397973103 cites W2079796426 @default.
- W2397973103 cites W2082053713 @default.
- W2397973103 cites W2083485319 @default.
- W2397973103 cites W2095268798 @default.
- W2397973103 cites W2096317893 @default.
- W2397973103 cites W2096772012 @default.
- W2397973103 cites W2102326852 @default.
- W2397973103 cites W2105263388 @default.
- W2397973103 cites W2105265053 @default.
- W2397973103 cites W2106411160 @default.
- W2397973103 cites W2108648971 @default.
- W2397973103 cites W2111393584 @default.
- W2397973103 cites W2116771437 @default.
- W2397973103 cites W2117820310 @default.
- W2397973103 cites W2124966303 @default.
- W2397973103 cites W2126317966 @default.
- W2397973103 cites W2126495538 @default.
- W2397973103 cites W2129981357 @default.
- W2397973103 cites W2130570549 @default.
- W2397973103 cites W2140799114 @default.
- W2397973103 cites W2142593697 @default.
- W2397973103 cites W2144568374 @default.
- W2397973103 cites W2144766505 @default.
- W2397973103 cites W2147980767 @default.
- W2397973103 cites W2148513135 @default.
- W2397973103 cites W2150855258 @default.
- W2397973103 cites W2153454097 @default.
- W2397973103 cites W2153839551 @default.
- W2397973103 cites W2156942915 @default.
- W2397973103 cites W2157405334 @default.
- W2397973103 cites W2157643616 @default.
- W2397973103 cites W2159869147 @default.
- W2397973103 cites W2163284148 @default.
- W2397973103 cites W2165104566 @default.
- W2397973103 cites W2165574517 @default.
- W2397973103 cites W2166613497 @default.
- W2397973103 cites W2166788192 @default.
- W2397973103 cites W2167245776 @default.
- W2397973103 cites W2214282653 @default.
- W2397973103 cites W2343392246 @default.
- W2397973103 cites W2398696273 @default.
- W2397973103 cites W2913709946 @default.
- W2397973103 cites W4205457333 @default.
- W2397973103 doi "https://doi.org/10.1089/met.2015.0038" @default.
- W2397973103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4702428" @default.
- W2397973103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26125313" @default.
- W2397973103 hasPublicationYear "2015" @default.
- W2397973103 type Work @default.
- W2397973103 sameAs 2397973103 @default.
- W2397973103 citedByCount "14" @default.
- W2397973103 countsByYear W23979731032016 @default.
- W2397973103 countsByYear W23979731032017 @default.
- W2397973103 countsByYear W23979731032018 @default.
- W2397973103 countsByYear W23979731032019 @default.
- W2397973103 countsByYear W23979731032021 @default.
- W2397973103 countsByYear W23979731032022 @default.
- W2397973103 countsByYear W23979731032023 @default.