Matches in SemOpenAlex for { <https://semopenalex.org/work/W2397986148> ?p ?o ?g. }
- W2397986148 endingPage "15895" @default.
- W2397986148 startingPage "15881" @default.
- W2397986148 abstract "An emerging number of non-chemokine mediators are found to bind to classical chemokine receptors and to elicit critical biological responses. Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that exhibits chemokine-like activities through non-cognate interactions with the chemokine receptors CXCR2 and CXCR4, in addition to activating the type II receptor CD74. Activation of the MIF-CXCR2 and -CXCR4 axes promotes leukocyte recruitment, mediating the exacerbating role of MIF in atherosclerosis and contributing to the wealth of other MIF biological activities. Although the structural basis of the MIF-CXCR2 interaction has been well studied and was found to engage a pseudo-ELR and an N-like loop motif, nothing is known about the regions of CXCR4 and MIF that are involved in binding to each other. Using a genetic strain of Saccharomyces cerevisiae that expresses a functional CXCR4 receptor, site-specific mutagenesis, hybrid CXCR3/CXCR4 receptors, pharmacological reagents, peptide array analysis, chemotaxis, fluorescence spectroscopy, and circular dichroism, we provide novel molecular information about the structural elements that govern the interaction between MIF and CXCR4. The data identify similarities with classical chemokine-receptor interactions but also provide evidence for a partial allosteric agonist compared with CXCL12 that is possible due to the two binding sites of CXCR4." @default.
- W2397986148 created "2016-06-24" @default.
- W2397986148 creator A5001597686 @default.
- W2397986148 creator A5001883769 @default.
- W2397986148 creator A5015954991 @default.
- W2397986148 creator A5020924533 @default.
- W2397986148 creator A5021681644 @default.
- W2397986148 creator A5023960735 @default.
- W2397986148 creator A5032494718 @default.
- W2397986148 creator A5054691505 @default.
- W2397986148 creator A5061359662 @default.
- W2397986148 creator A5063619843 @default.
- W2397986148 creator A5065012856 @default.
- W2397986148 creator A5069557619 @default.
- W2397986148 creator A5072194652 @default.
- W2397986148 creator A5080194585 @default.
- W2397986148 creator A5086963252 @default.
- W2397986148 date "2016-07-01" @default.
- W2397986148 modified "2023-10-16" @default.
- W2397986148 title "Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions" @default.
- W2397986148 cites W109149868 @default.
- W2397986148 cites W1502471364 @default.
- W2397986148 cites W1540323116 @default.
- W2397986148 cites W1543575007 @default.
- W2397986148 cites W1586392520 @default.
- W2397986148 cites W1597760950 @default.
- W2397986148 cites W1874492336 @default.
- W2397986148 cites W1922705469 @default.
- W2397986148 cites W1941070784 @default.
- W2397986148 cites W1963984954 @default.
- W2397986148 cites W1964083898 @default.
- W2397986148 cites W1964408193 @default.
- W2397986148 cites W1966874741 @default.
- W2397986148 cites W1971588558 @default.
- W2397986148 cites W1972056955 @default.
- W2397986148 cites W1973473416 @default.
- W2397986148 cites W1973610607 @default.
- W2397986148 cites W1975740938 @default.
- W2397986148 cites W1979244891 @default.
- W2397986148 cites W1980471149 @default.
- W2397986148 cites W1983783590 @default.
- W2397986148 cites W1988778953 @default.
- W2397986148 cites W1989832114 @default.
- W2397986148 cites W1991922050 @default.
- W2397986148 cites W1994015218 @default.
- W2397986148 cites W1997868017 @default.
- W2397986148 cites W2001220125 @default.
- W2397986148 cites W2012759923 @default.
- W2397986148 cites W2013839742 @default.
- W2397986148 cites W2020601776 @default.
- W2397986148 cites W2021256296 @default.
- W2397986148 cites W2026137685 @default.
- W2397986148 cites W2026192283 @default.
- W2397986148 cites W2026589915 @default.
- W2397986148 cites W2026729873 @default.
- W2397986148 cites W2027876574 @default.
- W2397986148 cites W2029174607 @default.
- W2397986148 cites W2029479572 @default.
- W2397986148 cites W2034013835 @default.
- W2397986148 cites W2039399096 @default.
- W2397986148 cites W2044815206 @default.
- W2397986148 cites W2045517532 @default.
- W2397986148 cites W2047297009 @default.
- W2397986148 cites W2047567287 @default.
- W2397986148 cites W2051137913 @default.
- W2397986148 cites W2051318436 @default.
- W2397986148 cites W2061631515 @default.
- W2397986148 cites W2062148688 @default.
- W2397986148 cites W2062824264 @default.
- W2397986148 cites W2066963386 @default.
- W2397986148 cites W2067583186 @default.
- W2397986148 cites W2068036925 @default.
- W2397986148 cites W2071858539 @default.
- W2397986148 cites W2075416959 @default.
- W2397986148 cites W2077008732 @default.
- W2397986148 cites W2082180266 @default.
- W2397986148 cites W2087441379 @default.
- W2397986148 cites W2097197630 @default.
- W2397986148 cites W2097632784 @default.
- W2397986148 cites W2104159258 @default.
- W2397986148 cites W2104477830 @default.
- W2397986148 cites W2104918497 @default.
- W2397986148 cites W2105850524 @default.
- W2397986148 cites W2108285949 @default.
- W2397986148 cites W2110929110 @default.
- W2397986148 cites W2114650590 @default.
- W2397986148 cites W2115359460 @default.
- W2397986148 cites W2117440442 @default.
- W2397986148 cites W2129971584 @default.
- W2397986148 cites W2131117602 @default.
- W2397986148 cites W2132280604 @default.
- W2397986148 cites W2134249102 @default.
- W2397986148 cites W2136990296 @default.
- W2397986148 cites W2138437398 @default.
- W2397986148 cites W2146933058 @default.
- W2397986148 cites W2147322788 @default.
- W2397986148 cites W2149689090 @default.
- W2397986148 cites W2152853006 @default.