Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398045625> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2398045625 endingPage "17" @default.
- W2398045625 startingPage "9" @default.
- W2398045625 abstract "To assess the relationship between the dynamic pattern of IGF-I levels and chosen biochemical markers of bone metabolism in ovariectomized rats - a model of postmenopausal osteoporosis.Six-month-old rats were randomized to sham operation (control group) or ovariectomy. Serum levels of insulin-like growth factor (IGF-I) and chosen biochemical markers of bone metabolism (alkaline phosphatase - ALP, carboxyterminal propeptide of type I procollagen - PICP, cross-linked carboxyterminal telopeptide of type I collagen - ICTP in serum as well as urinary excretion of hydroxyproline - HYP and total calcium - Ca) were measured before (group 0) and 1, 2, 3, 4, 6, 8, 12, 16, 20, 24 and 28 weeks after the operation.In a model of experimental osteoporosis induced by ovariectomy in female rats a distinct tendency to decrease the IGF-I concentrations was shown. Differences were significant in relation to the control group in a period from 2 to 28 weeks after operation. Ovariectomy stimulated the values of studied markers of bone metabolism; it was more intensified in regard to resorption markers. Significant ICTP and HYP concentrations' changes, in relation to the control group, were shown in the some period and total calcium - from 2 to 16 weeks after ovariectomy. However, the values of studied markers of bone formation were generally changing to a slight degree. Significant differences of ALP activity, in relation to the control group, were observed only at 8 and 20 weeks, while those of PICP concentrations were found at in 4, 8 and 12 weeks after the operation. The alterations in the levels of IGF-I correlated significantly and negatively with the changes in ALP activity as well as in PICP, ICTP, HYP and Ca concentrations both in ovariectomized and control rats. This relation was more expressed in the ovariectomized group.Our findings suggest that secondary changes in IGF-I concentration, due to the deficiency of sex hormones, results in altered bone metabolism in ovariectomized rats." @default.
- W2398045625 created "2016-06-24" @default.
- W2398045625 creator A5003314722 @default.
- W2398045625 creator A5011791445 @default.
- W2398045625 creator A5053698057 @default.
- W2398045625 creator A5054519213 @default.
- W2398045625 creator A5084788244 @default.
- W2398045625 date "2002-03-01" @default.
- W2398045625 modified "2023-10-17" @default.
- W2398045625 title "Dynamic pattern of IGF-I and chosen biochemical markers of bone metabolism in a rat model of postmenopausal osteoporosis." @default.
- W2398045625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11971746" @default.
- W2398045625 hasPublicationYear "2002" @default.
- W2398045625 type Work @default.
- W2398045625 sameAs 2398045625 @default.
- W2398045625 citedByCount "2" @default.
- W2398045625 countsByYear W23980456252013 @default.
- W2398045625 crossrefType "journal-article" @default.
- W2398045625 hasAuthorship W2398045625A5003314722 @default.
- W2398045625 hasAuthorship W2398045625A5011791445 @default.
- W2398045625 hasAuthorship W2398045625A5053698057 @default.
- W2398045625 hasAuthorship W2398045625A5054519213 @default.
- W2398045625 hasAuthorship W2398045625A5084788244 @default.
- W2398045625 hasConcept C10146269 @default.
- W2398045625 hasConcept C125870589 @default.
- W2398045625 hasConcept C126322002 @default.
- W2398045625 hasConcept C131075544 @default.
- W2398045625 hasConcept C134018914 @default.
- W2398045625 hasConcept C160160445 @default.
- W2398045625 hasConcept C170033053 @default.
- W2398045625 hasConcept C181199279 @default.
- W2398045625 hasConcept C185592680 @default.
- W2398045625 hasConcept C2776541429 @default.
- W2398045625 hasConcept C2779797417 @default.
- W2398045625 hasConcept C2780644872 @default.
- W2398045625 hasConcept C55493867 @default.
- W2398045625 hasConcept C62231903 @default.
- W2398045625 hasConcept C64348721 @default.
- W2398045625 hasConcept C673006 @default.
- W2398045625 hasConcept C71315377 @default.
- W2398045625 hasConcept C71924100 @default.
- W2398045625 hasConcept C8264082 @default.
- W2398045625 hasConceptScore W2398045625C10146269 @default.
- W2398045625 hasConceptScore W2398045625C125870589 @default.
- W2398045625 hasConceptScore W2398045625C126322002 @default.
- W2398045625 hasConceptScore W2398045625C131075544 @default.
- W2398045625 hasConceptScore W2398045625C134018914 @default.
- W2398045625 hasConceptScore W2398045625C160160445 @default.
- W2398045625 hasConceptScore W2398045625C170033053 @default.
- W2398045625 hasConceptScore W2398045625C181199279 @default.
- W2398045625 hasConceptScore W2398045625C185592680 @default.
- W2398045625 hasConceptScore W2398045625C2776541429 @default.
- W2398045625 hasConceptScore W2398045625C2779797417 @default.
- W2398045625 hasConceptScore W2398045625C2780644872 @default.
- W2398045625 hasConceptScore W2398045625C55493867 @default.
- W2398045625 hasConceptScore W2398045625C62231903 @default.
- W2398045625 hasConceptScore W2398045625C64348721 @default.
- W2398045625 hasConceptScore W2398045625C673006 @default.
- W2398045625 hasConceptScore W2398045625C71315377 @default.
- W2398045625 hasConceptScore W2398045625C71924100 @default.
- W2398045625 hasConceptScore W2398045625C8264082 @default.
- W2398045625 hasIssue "1" @default.
- W2398045625 hasLocation W23980456251 @default.
- W2398045625 hasOpenAccess W2398045625 @default.
- W2398045625 hasPrimaryLocation W23980456251 @default.
- W2398045625 hasRelatedWork W1987767691 @default.
- W2398045625 hasRelatedWork W2015972230 @default.
- W2398045625 hasRelatedWork W2026745053 @default.
- W2398045625 hasRelatedWork W2049047086 @default.
- W2398045625 hasRelatedWork W2054384551 @default.
- W2398045625 hasRelatedWork W2091140190 @default.
- W2398045625 hasRelatedWork W2112695616 @default.
- W2398045625 hasRelatedWork W2306712891 @default.
- W2398045625 hasRelatedWork W2392163602 @default.
- W2398045625 hasRelatedWork W2398045625 @default.
- W2398045625 hasVolume "36" @default.
- W2398045625 isParatext "false" @default.
- W2398045625 isRetracted "false" @default.
- W2398045625 magId "2398045625" @default.
- W2398045625 workType "article" @default.