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- W2398085325 abstract "Schistosomiasis affects approximately 2,5 million people Brazil, being one of main parasitic helminthes this country. The majority of the S. mansoni -infected individuals develop the intestinal clinical form of disease and many studies demonstrate, in vitro '', that, the chronic phase of infection, occurs predominantly a type 2 immune response, being the infection intensity one of the factors that influence this response. However, few studies have evaluated the relationship between infection intensity and the immune response profile ofpatients with intestinal chronic schistosomiasis mansoni. Thus, we evaluated the influence of the intensity of infection with S. mansoni on the immunologic markers of the cellular response: IL-2, IL-4, IL-5, IL-10, IFN-γ , TNF- α , eotaxin and eosinophils; and markers of the humoral response: IgG4 and IgE, against antigens of the egg (SEA) and adult worm (SWAP), patients with intestinal clinical chronic schistosomiasis mansoni, residents endemic area of Virgem das Gracas, Ponto dos Volantes municipality, Minas Gerais, Brazil. As for thecellular response, our results suggest that, intestinal clinical form of the disease, there is a predominance of a type 2 response, with an increase the levels of IL-5, IL-10, eosinophils and eotaxin, being the immune response modulation related with IL-10 production and thatthese factors are influenced by infection intensity. As for the humoral response, our data suggest that, the intestinal clinical form, occurs a change IgE/IgG4 rate, specific against SEA and SWAP, with an increase the levels of IgG4 and reduction the levels of IgE. Ourresults suggest that these changes can be influenced by IL-10, a context dependent on the infection intensit" @default.
- W2398085325 created "2016-06-24" @default.
- W2398085325 creator A5059427662 @default.
- W2398085325 date "2005-01-01" @default.
- W2398085325 modified "2023-09-27" @default.
- W2398085325 title "Influência da intensidade de infecção pelo Schistosoma mansoni sobre o perfil de marcadores imunológicos da resposta celular e humoral na forma clínica intestinal da esquistossomose." @default.
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