FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398183597> ?p ?o ?g. }

• W2398183597 endingPage "1176" @default.
• W2398183597 startingPage "1170" @default.
• W2398183597 abstract "The pivotal roles of phosphatidylinositol 3-kinases (PI3Ks) in human cancers have inspired active development of small molecules to inhibit these lipid kinases. However, the first-generation pan-PI3K and dual-PI3K/mTOR inhibitors have encountered problems in clinical trials, with limited efficacies as a monotherapeutic agent as well as a relatively high rate of side effects. It is increasingly recognized that different PI3K isoforms play non-redundant roles in particular tumor types, which has prompted the development of isoform-selective inhibitors for pre-selected patients with the aim for improving efficacy while decreasing undesirable side effects. The success of PI3K isoform-selective inhibitors is represented by CAL101 (Idelalisib), a first-in-class PI3Kδ-selective small-molecule inhibitor that has been approved by the FDA for the treatment of chronic lymphocytic leukemia, indolent B-cell non-Hodgkin's lymphoma and relapsed small lymphocytic lymphoma. Inhibitors targeting other PI3K isoforms are also being extensively developed. This review focuses on the recent progress in development of PI3K isoform-selective inhibitors for cancer therapy. A deeper understanding of the action modes of novel PI3K isoform-selective inhibitors will provide valuable information to further validate the concept of targeting specific PI3K isoforms, while the identification of biomarkers to stratify patients who are likely to benefit from the therapy will be essential for the success of these agents." @default.
• W2398183597 created "2016-06-24" @default.
• W2398183597 creator A5044936528 @default.
• W2398183597 creator A5077391385 @default.
• W2398183597 creator A5089348951 @default.
• W2398183597 date "2015-09-14" @default.
• W2398183597 modified "2023-10-16" @default.
• W2398183597 title "PI3K isoform-selective inhibitors: next-generation targeted cancer therapies" @default.
• W2398183597 cites W1567253059 @default.
• W2398183597 cites W1583314344 @default.
• W2398183597 cites W1795892439 @default.
• W2398183597 cites W1964554012 @default.
• W2398183597 cites W1977556560 @default.
• W2398183597 cites W1980040544 @default.
• W2398183597 cites W1994824666 @default.
• W2398183597 cites W2010729236 @default.
• W2398183597 cites W2025745090 @default.
• W2398183597 cites W2025786205 @default.
• W2398183597 cites W2027623923 @default.
• W2398183597 cites W2027971058 @default.
• W2398183597 cites W2031681802 @default.
• W2398183597 cites W2038053631 @default.
• W2398183597 cites W2038444072 @default.
• W2398183597 cites W2045608879 @default.
• W2398183597 cites W2052618262 @default.
• W2398183597 cites W2052763184 @default.
• W2398183597 cites W2057366353 @default.
• W2398183597 cites W2057370954 @default.
• W2398183597 cites W2066564017 @default.
• W2398183597 cites W2067342462 @default.
• W2398183597 cites W2071463092 @default.
• W2398183597 cites W2077379867 @default.
• W2398183597 cites W2078521685 @default.
• W2398183597 cites W2085736853 @default.
• W2398183597 cites W2101982508 @default.
• W2398183597 cites W2121510983 @default.
• W2398183597 cites W2127355894 @default.
• W2398183597 cites W2134861285 @default.
• W2398183597 cites W2141766988 @default.
• W2398183597 cites W2148274139 @default.
• W2398183597 cites W2149941857 @default.
• W2398183597 cites W2150798124 @default.
• W2398183597 cites W2165992619 @default.
• W2398183597 cites W2166188515 @default.
• W2398183597 cites W2169450835 @default.
• W2398183597 cites W2318012531 @default.
• W2398183597 cites W2509319388 @default.
• W2398183597 doi "https://doi.org/10.1038/aps.2015.71" @default.
• W2398183597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4648175" @default.
• W2398183597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26364801" @default.
• W2398183597 hasPublicationYear "2015" @default.
• W2398183597 type Work @default.
• W2398183597 sameAs 2398183597 @default.
• W2398183597 citedByCount "87" @default.
• W2398183597 countsByYear W23981835972015 @default.
• W2398183597 countsByYear W23981835972016 @default.
• W2398183597 countsByYear W23981835972017 @default.
• W2398183597 countsByYear W23981835972018 @default.
• W2398183597 countsByYear W23981835972019 @default.
• W2398183597 countsByYear W23981835972020 @default.
• W2398183597 countsByYear W23981835972021 @default.
• W2398183597 countsByYear W23981835972022 @default.
• W2398183597 countsByYear W23981835972023 @default.
• W2398183597 crossrefType "journal-article" @default.
• W2398183597 hasAuthorship W2398183597A5044936528 @default.
• W2398183597 hasAuthorship W2398183597A5077391385 @default.
• W2398183597 hasAuthorship W2398183597A5089348951 @default.
• W2398183597 hasBestOaLocation W23981835971 @default.
• W2398183597 hasConcept C104317684 @default.
• W2398183597 hasConcept C121608353 @default.
• W2398183597 hasConcept C126322002 @default.
• W2398183597 hasConcept C161624437 @default.
• W2398183597 hasConcept C184235292 @default.
• W2398183597 hasConcept C203014093 @default.
• W2398183597 hasConcept C2777938653 @default.
• W2398183597 hasConcept C2778461978 @default.
• W2398183597 hasConcept C2779260929 @default.
• W2398183597 hasConcept C2779878957 @default.
• W2398183597 hasConcept C502942594 @default.
• W2398183597 hasConcept C53345823 @default.
• W2398183597 hasConcept C55493867 @default.
• W2398183597 hasConcept C62478195 @default.
• W2398183597 hasConcept C71924100 @default.
• W2398183597 hasConcept C86554907 @default.
• W2398183597 hasConcept C86803240 @default.
• W2398183597 hasConcept C98274493 @default.
• W2398183597 hasConceptScore W2398183597C104317684 @default.
• W2398183597 hasConceptScore W2398183597C121608353 @default.
• W2398183597 hasConceptScore W2398183597C126322002 @default.
• W2398183597 hasConceptScore W2398183597C161624437 @default.
• W2398183597 hasConceptScore W2398183597C184235292 @default.
• W2398183597 hasConceptScore W2398183597C203014093 @default.
• W2398183597 hasConceptScore W2398183597C2777938653 @default.
• W2398183597 hasConceptScore W2398183597C2778461978 @default.
• W2398183597 hasConceptScore W2398183597C2779260929 @default.
• W2398183597 hasConceptScore W2398183597C2779878957 @default.
• W2398183597 hasConceptScore W2398183597C502942594 @default.
• W2398183597 hasConceptScore W2398183597C53345823 @default.

• next