Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398337462> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2398337462 abstract "Male Munich-Wistar rats were subjected to 1 2/3 nephrectomy. One group received no therapy (C). A second group received daily doses of methylprednisolone (MP). A third group received MP plus the angiotensin I converting enzyme inhibitor (CEI) benzazepril. A fourth group received CEI alone. Half of the rats in each group underwent micropuncture study 2 weeks after ablation. Untreated rats exhibited systemic hypertension and elevation of the single nephron glomerular filtration rate (SNGFR), due to glomerular capillary hyperperfusion and hypertension. Administration of MP resulted in comparable systemic hypertension with further elevation of SNGFR due to even higher values for glomerular perfusion and hydraulic pressure (PGC). Concurrent treatment with CEI-controlled systemic and glomerular hypertension despite equivalent renal ablation and comparable doses of MP. After 12 weeks untreated rats demonstrated continued systemic hypertension, progressive proteinuria, and eventual glomerular sclerosis. Addition of MP dramatically accelerated the development of proteinuria and glomerular sclerosis, while CEI afforded striking protection against disease progression. Thus, potent vasodilator glucocorticoids may amplify hemodynamically mediated glomerular injury, whereas control of systemic and glomerular hypertension prevents this undesirable consequence of chronic steroid therapy." @default.
- W2398337462 created "2016-06-24" @default.
- W2398337462 creator A5013889724 @default.
- W2398337462 creator A5016263167 @default.
- W2398337462 creator A5024812806 @default.
- W2398337462 creator A5088191963 @default.
- W2398337462 date "1988-01-01" @default.
- W2398337462 modified "2023-10-16" @default.
- W2398337462 title "Glucocorticoids Amplify Glomerular Injury in Rats with Renal Ablation" @default.
- W2398337462 doi "https://doi.org/10.1093/ajh/1.1.54" @default.
- W2398337462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3370134" @default.
- W2398337462 hasPublicationYear "1988" @default.
- W2398337462 type Work @default.
- W2398337462 sameAs 2398337462 @default.
- W2398337462 citedByCount "6" @default.
- W2398337462 crossrefType "journal-article" @default.
- W2398337462 hasAuthorship W2398337462A5013889724 @default.
- W2398337462 hasAuthorship W2398337462A5016263167 @default.
- W2398337462 hasAuthorship W2398337462A5024812806 @default.
- W2398337462 hasAuthorship W2398337462A5088191963 @default.
- W2398337462 hasConcept C126322002 @default.
- W2398337462 hasConcept C126894567 @default.
- W2398337462 hasConcept C134018914 @default.
- W2398337462 hasConcept C159641895 @default.
- W2398337462 hasConcept C2777390665 @default.
- W2398337462 hasConcept C2779561371 @default.
- W2398337462 hasConcept C2780091579 @default.
- W2398337462 hasConcept C2780227381 @default.
- W2398337462 hasConcept C2780372218 @default.
- W2398337462 hasConcept C71924100 @default.
- W2398337462 hasConcept C84393581 @default.
- W2398337462 hasConceptScore W2398337462C126322002 @default.
- W2398337462 hasConceptScore W2398337462C126894567 @default.
- W2398337462 hasConceptScore W2398337462C134018914 @default.
- W2398337462 hasConceptScore W2398337462C159641895 @default.
- W2398337462 hasConceptScore W2398337462C2777390665 @default.
- W2398337462 hasConceptScore W2398337462C2779561371 @default.
- W2398337462 hasConceptScore W2398337462C2780091579 @default.
- W2398337462 hasConceptScore W2398337462C2780227381 @default.
- W2398337462 hasConceptScore W2398337462C2780372218 @default.
- W2398337462 hasConceptScore W2398337462C71924100 @default.
- W2398337462 hasConceptScore W2398337462C84393581 @default.
- W2398337462 hasLocation W23983374621 @default.
- W2398337462 hasLocation W23983374622 @default.
- W2398337462 hasOpenAccess W2398337462 @default.
- W2398337462 hasPrimaryLocation W23983374621 @default.
- W2398337462 hasRelatedWork W1894184984 @default.
- W2398337462 hasRelatedWork W1993083581 @default.
- W2398337462 hasRelatedWork W2006297346 @default.
- W2398337462 hasRelatedWork W2096714571 @default.
- W2398337462 hasRelatedWork W2202376584 @default.
- W2398337462 hasRelatedWork W2214628828 @default.
- W2398337462 hasRelatedWork W2363496730 @default.
- W2398337462 hasRelatedWork W2746956670 @default.
- W2398337462 hasRelatedWork W3098903879 @default.
- W2398337462 hasRelatedWork W3160593593 @default.
- W2398337462 isParatext "false" @default.
- W2398337462 isRetracted "false" @default.
- W2398337462 magId "2398337462" @default.
- W2398337462 workType "article" @default.