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- W2398344267 abstract "We report the results of immunosuppressive treatments of 13 patients with rnultifocal motor neuropathy and elevated titers of serum antibodies to the GM1 ganglioside. All patients failed to respond to oral prednisone. There was no clinical response in 4 patients treated with plasma exchange. Nine patients received cyclophosphamide, with clinical improvement and fall in antibody titers in 8. In 3 patients, cyclophosphamide was discontinued with ensuing clinical relapse and rise in the titers of serum anti-GM1 antibodies. These patients provide further evidence for the efficacy of cyclophosphamide therapy in patients with multifocal motor neuropathy. Feldman EL, Bromberg MB, Albers JW, Pestronk A. Immunosuppressive treatment in multifocal motor neuropathy. Ann Neurol 1991;30:397-401 Lower motor neuron syndromes can be divided into clinical subsets based on the patterns of weakness, electrodiagnostic abnormalities, and serum antiglycolipid antibody activity [I]. One such syndrome, multifocal motor neuropathy (MMN), is characterized by distal, asymmetrical weakness and conduction block on motor but not sensory axons [ 1-41. High titers of serum antibodies to GM1 ganglioside are common in this syndrome [I, 2) and in acquired lower motor neuron syndromes in general 11, 5-91. Individual patient reports suggest that MMN may respond to immunotherapy [2). Cytotoxic medications such as cyclophosphamide may be useful in producing clinical improvement, that is, an increase in strength C2, 31. In this study, we report our retrospective experience with the treatment of a series of 13 patients with a diagnosis of MMN. Our results show that prednisone treatment, even in high doses, is not often associated with clinical benefit in patients with MMN. In contrast, improvement in strength commonly occurs within 3 to 6 months after institution of cyclophosphamide therapy. Further, there is usually a correlation between clinical improvement and reduction of titers of antiGMl antibodies." @default.
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- W2398344267 date "1991-01-01" @default.
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- W2398344267 title "Immunosuppressive Treatment in Multhocal Motor Neuropathy" @default.
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