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- W2398357175 abstract "Objective: To investigate the change of CORT and the level of GRmRNA of adrenal in CLP induced septic rats which were treated by Xuebijing, identify that Xuebijing can regulate the CORT and GRmRNA. Methods: 40 male rats were divided randomly into normal control group, sham group, saline group (Sepsis group), Xuebijing for treatment group. The model of sepsis was made by CLP. We observe the clinical manifestation of animal after CLP. We use the radio-immunity me- thod to detect the levels of CORT; using the RT-PCR method to measure the level of GRmRNA in adrenal. Results: In Sepsis group, the plasma CORT concentration (29.74 ± 1.65 ng/ml) was sig- nificantly higher than that in the normal control group (7.56 ± 0.89 ng/ml, P 0.05). In Sepsis group, the level of the GRmRNA in the adrenal tissue (0.80 ± 0.11) was significantly lower than that in the normal con- trol group (1.44 ± 0.07, P 0.05). Conclusion: In septic rats, the HPA axis was excessive activate. Xuebijing can decrease the level of CORT, increase the level of GRmRNA in adrenal, improve the excessive activate condition of HPA axis, and lessen the clinical manifestation." @default.
- W2398357175 created "2016-06-24" @default.
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- W2398357175 date "2015-01-01" @default.
- W2398357175 modified "2023-09-26" @default.
- W2398357175 title "Xuebijing Regulate the Hypothalamic-Pituitary-Adrenal Axis and the Level of GRmRNA of Adrenal in Septic Rats" @default.
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