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- W2398377426 abstract "Genetic factors combined with oxidative stress are major determinants of age-related hearing loss (ARHL), one of the most prevalent disorders of the elderly. Dwarf grey mice, Ggt1dwg/dwg, are homozygous for a loss of function mutation of the γ-glutamyl transferase 1 gene, which encodes an important antioxidant enzyme critical for the resynthesis of glutathione (GSH). Since GSH reduces oxidative damage, we hypothesized that Ggt1dwg/dwg mice would be susceptible to ARHL. Surprisingly, otoacoustic emissions and cochlear microphonic potentials, which reflect cochlear outer hair cell (OHC) function, were largely unaffected in mutant mice, whereas auditory brainstem responses and the compound action potential were grossly abnormal. These functional deficits were associated with an unusual and selective loss of inner hair cells (IHC), but retention of OHC and auditory nerve fibers. Remarkably, hearing deficits and IHC loss were completely prevented by N-acetyl-L-cysteine, which induces de novo synthesis of GSH; however, hearing deficits and IHC loss reappeared when treatment was discontinued. Ggt1dwg/dwgmice represent an important new model for investigating ARHL, therapeutic interventions, and understanding the perceptual and electrophysiological consequences of sensory deprivation caused by the loss of sensory input exclusively from IHC." @default.
- W2398377426 created "2016-06-24" @default.
- W2398377426 creator A5000259116 @default.
- W2398377426 creator A5013936863 @default.
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- W2398377426 creator A5068192594 @default.
- W2398377426 creator A5068398472 @default.
- W2398377426 date "2016-03-14" @default.
- W2398377426 modified "2023-10-11" @default.
- W2398377426 title "N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice" @default.
- W2398377426 cites W1112196583 @default.
- W2398377426 cites W1169067896 @default.
- W2398377426 cites W1502289101 @default.
- W2398377426 cites W1530433556 @default.
- W2398377426 cites W1755671302 @default.
- W2398377426 cites W183069189 @default.
- W2398377426 cites W1855015466 @default.
- W2398377426 cites W1939052857 @default.
- W2398377426 cites W1964248735 @default.
- W2398377426 cites W1966939142 @default.
- W2398377426 cites W1967381132 @default.
- W2398377426 cites W1969401957 @default.
- W2398377426 cites W1970698282 @default.
- W2398377426 cites W1974133523 @default.
- W2398377426 cites W1974270735 @default.
- W2398377426 cites W1974980963 @default.
- W2398377426 cites W1976219423 @default.
- W2398377426 cites W1978080323 @default.
- W2398377426 cites W1979526541 @default.
- W2398377426 cites W1979840983 @default.
- W2398377426 cites W1986733224 @default.
- W2398377426 cites W1988283674 @default.
- W2398377426 cites W1989683926 @default.
- W2398377426 cites W1990470711 @default.
- W2398377426 cites W1990647439 @default.
- W2398377426 cites W1993458346 @default.
- W2398377426 cites W1996135966 @default.
- W2398377426 cites W1999776105 @default.
- W2398377426 cites W2004847756 @default.
- W2398377426 cites W2005543346 @default.
- W2398377426 cites W2006018333 @default.
- W2398377426 cites W2006288165 @default.
- W2398377426 cites W2008300701 @default.
- W2398377426 cites W2010985773 @default.
- W2398377426 cites W2011210106 @default.
- W2398377426 cites W2012624830 @default.
- W2398377426 cites W2012717802 @default.
- W2398377426 cites W2012973109 @default.
- W2398377426 cites W2013441522 @default.
- W2398377426 cites W2013496968 @default.
- W2398377426 cites W2014390603 @default.
- W2398377426 cites W2015647734 @default.
- W2398377426 cites W2016502180 @default.
- W2398377426 cites W2019108060 @default.
- W2398377426 cites W2020991261 @default.
- W2398377426 cites W2021697693 @default.
- W2398377426 cites W2023194082 @default.
- W2398377426 cites W2026459212 @default.
- W2398377426 cites W2030352252 @default.
- W2398377426 cites W2031375292 @default.
- W2398377426 cites W2031713270 @default.
- W2398377426 cites W2033198883 @default.
- W2398377426 cites W2040259366 @default.
- W2398377426 cites W2042029123 @default.
- W2398377426 cites W2042040204 @default.
- W2398377426 cites W2043373896 @default.
- W2398377426 cites W2044687954 @default.
- W2398377426 cites W2046280353 @default.
- W2398377426 cites W2056774798 @default.
- W2398377426 cites W2057029719 @default.
- W2398377426 cites W2057663429 @default.
- W2398377426 cites W2058005929 @default.
- W2398377426 cites W2060618882 @default.
- W2398377426 cites W2061709990 @default.
- W2398377426 cites W2062762488 @default.
- W2398377426 cites W2064230788 @default.
- W2398377426 cites W2064414015 @default.
- W2398377426 cites W2065371942 @default.
- W2398377426 cites W2066256064 @default.
- W2398377426 cites W2067814359 @default.
- W2398377426 cites W2068244727 @default.
- W2398377426 cites W2069245399 @default.
- W2398377426 cites W2069361188 @default.
- W2398377426 cites W2069455756 @default.
- W2398377426 cites W2069559293 @default.
- W2398377426 cites W2069589645 @default.
- W2398377426 cites W2073445576 @default.
- W2398377426 cites W2075039068 @default.
- W2398377426 cites W207578233 @default.
- W2398377426 cites W2078045632 @default.
- W2398377426 cites W2078291178 @default.
- W2398377426 cites W2078357046 @default.
- W2398377426 cites W2080607432 @default.
- W2398377426 cites W2080713395 @default.