FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398450103> ?p ?o ?g. }

• W2398450103 abstract "Background Axial spondyloarthritis (axSpA) is characterised by a substantial fluctuation of inflammation with resolution and new occurrence of inflammatory lesions in the course of the disease. However, it is not clear, whether new osteitis lesions as detected by magnetic resonance imaging (MRI) occur on random or there are factors predicting a certain localisation of new lesions. Objectives To investigate the localisation of newly occurred osteitis lesions in the sacroiliac joints (SIJ) and in the spine in patients with early axSpA in the Part II of the Infliximab As First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial (INFAST) [1]. Methods Part I of the INFAST study was a double-blind, randomized controlled trial of infliximab (IFX) - Remicade – in patients with early ( Results At W28 (end of part I, the new baseline for part II), osteitis was present in 13.1% vs. 14.3% SIJ quadrants and 3.2% vs. 5.2% VUs in the NPX vs. no treatment groups, respectively. At W52, 39.2% vs. 28.7% of SIJ quadrants (p=0.008) and 8.1% vs. 14.0% of VUs (p Osteitis at W52 in the SIJ occurred more frequently in the quadrants with fatty lesions observed at W28 (30%) as compared to those quadrants without any lesions at W28 (15.4%) – table. However, presence of inflammation at W0 (that disappeared at W28 due to the treatment in the phase I of the study) was even a stronger predictor of new osteitis at W52, which occurred in 39.2% of the quadrants affected by osteitis at W0 as compared to 13.8% of the quadrants without osteitis at W0. Presence of fatty lesions at W0 was not significantly associated with new osteitis lesions later on - table. Similarly for the spine, new osteitis lesions at W52 occurred more frequently in VUs with fatty lesions at W28 as compared to VUs without any lesions (21.3% vs. 5.7%); also fatty lesions at W0 was significantly associated with new osteitis lesions at W52 – table. However, the highest risk of new osteitis lesions at W52 was associated with osteitis observed at W0: new lesion occurred at W52 in 43.9% of VUs with osteitis at W0, as compared to 3% of the VU without previous osteitis - table. Conclusions Naproxen therapy did not prevent occurrence of new inflammatory lesions. New inflammatory lesions in axial spondyloarthritis are more likely to occur in the areas already affected by inflammation in the past. References Sieper J, et al. Ann Rheum Dis 2014;73:101-7. Althoff CE, et al. Ann Rheum Dis 2013;72:967-73. Acknowledgements The MRI analysis substudy was supported by an unrestricted research grant from MSD. Disclosure of Interest D. Poddubnyy Consultant for: AbbVie, MSD, Pfizer, UCB, Speakers bureau: AbbVie, MSD, Pfizer, UCB, J. Sieper Grant/research support from: Abbvie, MSD, Pfizer, Consultant for: AbbVie, MSD, Pfizer, UCB, Speakers bureau: AbbVie, MSD, Pfizer, UCB" @default.
• W2398450103 created "2016-06-24" @default.
• W2398450103 creator A5029965399 @default.
• W2398450103 creator A5085745432 @default.
• W2398450103 date "2015-06-01" @default.
• W2398450103 modified "2023-10-02" @default.
• W2398450103 title "SAT0240 New Inflammatory Lesions in Axial Spondyloarthritis are More Likely to Occur in the Areas Already Affected by Inflammation in the Past" @default.
• W2398450103 doi "https://doi.org/10.1136/annrheumdis-2015-eular.3832" @default.
• W2398450103 hasPublicationYear "2015" @default.
• W2398450103 type Work @default.
• W2398450103 sameAs 2398450103 @default.
• W2398450103 citedByCount "0" @default.
• W2398450103 crossrefType "journal-article" @default.
• W2398450103 hasAuthorship W2398450103A5029965399 @default.
• W2398450103 hasAuthorship W2398450103A5085745432 @default.
• W2398450103 hasConcept C126322002 @default.
• W2398450103 hasConcept C126838900 @default.
• W2398450103 hasConcept C141071460 @default.
• W2398450103 hasConcept C143409427 @default.
• W2398450103 hasConcept C2776213234 @default.
• W2398450103 hasConcept C2776260265 @default.
• W2398450103 hasConcept C2777077863 @default.
• W2398450103 hasConcept C2777138892 @default.
• W2398450103 hasConcept C2777453003 @default.
• W2398450103 hasConcept C2778579456 @default.
• W2398450103 hasConcept C2779134260 @default.
• W2398450103 hasConcept C2780551157 @default.
• W2398450103 hasConcept C2781343496 @default.
• W2398450103 hasConcept C71924100 @default.
• W2398450103 hasConceptScore W2398450103C126322002 @default.
• W2398450103 hasConceptScore W2398450103C126838900 @default.
• W2398450103 hasConceptScore W2398450103C141071460 @default.
• W2398450103 hasConceptScore W2398450103C143409427 @default.
• W2398450103 hasConceptScore W2398450103C2776213234 @default.
• W2398450103 hasConceptScore W2398450103C2776260265 @default.
• W2398450103 hasConceptScore W2398450103C2777077863 @default.
• W2398450103 hasConceptScore W2398450103C2777138892 @default.
• W2398450103 hasConceptScore W2398450103C2777453003 @default.
• W2398450103 hasConceptScore W2398450103C2778579456 @default.
• W2398450103 hasConceptScore W2398450103C2779134260 @default.
• W2398450103 hasConceptScore W2398450103C2780551157 @default.
• W2398450103 hasConceptScore W2398450103C2781343496 @default.
• W2398450103 hasConceptScore W2398450103C71924100 @default.
• W2398450103 hasLocation W23984501031 @default.
• W2398450103 hasOpenAccess W2398450103 @default.
• W2398450103 hasPrimaryLocation W23984501031 @default.
• W2398450103 hasRelatedWork W1214031983 @default.
• W2398450103 hasRelatedWork W2104749385 @default.
• W2398450103 hasRelatedWork W2126257512 @default.
• W2398450103 hasRelatedWork W2312331253 @default.
• W2398450103 hasRelatedWork W2316600428 @default.
• W2398450103 hasRelatedWork W2321951773 @default.
• W2398450103 hasRelatedWork W2322175380 @default.
• W2398450103 hasRelatedWork W2326585389 @default.
• W2398450103 hasRelatedWork W2327270077 @default.
• W2398450103 hasRelatedWork W2332806655 @default.
• W2398450103 hasRelatedWork W2332848619 @default.
• W2398450103 hasRelatedWork W2554235576 @default.
• W2398450103 hasRelatedWork W2910044056 @default.
• W2398450103 hasRelatedWork W2950442473 @default.
• W2398450103 hasRelatedWork W3000324410 @default.
• W2398450103 hasRelatedWork W3005430709 @default.
• W2398450103 hasRelatedWork W3026347911 @default.
• W2398450103 hasRelatedWork W3034341136 @default.
• W2398450103 hasRelatedWork W3165877871 @default.
• W2398450103 hasRelatedWork W2343312207 @default.
• W2398450103 isParatext "false" @default.
• W2398450103 isRetracted "false" @default.
• W2398450103 magId "2398450103" @default.
• W2398450103 workType "article" @default.