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• W2398498907 abstract "Gene duplication is a fundamental process in genome evolution. However, most young duplicates are degraded by loss-of-function mutations, and the factors that allow some duplicate pairs to survive long-term remain controversial. One class of models to explain duplicate retention invokes sub- or neofunctionalization, whereas others focus on sharing of gene dosage. RNA-sequencing data from 46 human and 26 mouse tissues indicate that subfunctionalization of expression evolves slowly and is rare among duplicates that arose within the placental mammals, possibly because tandem duplicates are coregulated by shared genomic elements. Instead, consistent with the dosage-sharing hypothesis, most young duplicates are down-regulated to match expression levels of single-copy genes. Thus, dosage sharing of expression allows for the initial survival of mammalian duplicates, followed by slower functional adaptation enabling long-term preservation." @default.
• W2398498907 created "2016-06-24" @default.
• W2398498907 creator A5018628335 @default.
• W2398498907 creator A5051388103 @default.
• W2398498907 date "2016-05-19" @default.
• W2398498907 modified "2023-10-12" @default.
• W2398498907 title "Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals" @default.
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• W2398498907 doi "https://doi.org/10.1126/science.aad8411" @default.
• W2398498907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5182070" @default.
• W2398498907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27199432" @default.
• W2398498907 hasPublicationYear "2016" @default.
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