Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398538703> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2398538703 endingPage "197" @default.
- W2398538703 startingPage "180" @default.
- W2398538703 abstract "Ganetespib is a potent second-generation inhibitor of heat-shock protein 90 (Hsp90), structurally consisting of a resorcinol moiety and a triazolone core. Ganetespib has shown robust anticancer activity against a broad variety of tumor cell lines where exposure resulted in the degradation of many well-known Hsp90 client proteins. In solid and hematological xenograft models of oncogene addiction, ganetespib has demonstrated potent antitumor efficacy both as a single agent and in combination with a number of widely used cancer therapeutics. Evaluation of the microregional activity of ganetespib in tumor xenografts showed that ganetespib efficiently distributed throughout tumor tissue, including hypoxic regions >150 μm from the microvasculature, to inhibit proliferation and induce apoptosis. Pre-clinical results with ganetespib have shown a reduction of levels of hypoxia induced factor-1alpha (HIF-1α), suggesting that the compound can reduce or disrupt new blood vessel formation (angiogenesis) and the emergence of new lesions (metastases). Ganetespib possesses an excellent safety profile and shows no evidence of cardiac, liver or ocular toxicity. Ganetespib is being evaluated in a number of clinical trials including lung and breast cancers. In a Phase IIb global, randomized, multi-center study of ganetespib in combination with docetaxel in lung adenocarcinoma patients, a favorable safety profile as well as meaningful improvements in overall survival have been observed. Noteworthy clinical benefits have also been seen in additional clinical trials using ganetespib as monotherapy." @default.
- W2398538703 created "2016-06-24" @default.
- W2398538703 creator A5067130524 @default.
- W2398538703 date "2013-10-30" @default.
- W2398538703 modified "2023-09-24" @default.
- W2398538703 title "Discovery and Development of Ganetespib" @default.
- W2398538703 cites W1988533633 @default.
- W2398538703 cites W2004703923 @default.
- W2398538703 cites W2016505307 @default.
- W2398538703 cites W2026888844 @default.
- W2398538703 cites W2042699875 @default.
- W2398538703 cites W2076080930 @default.
- W2398538703 cites W2090231065 @default.
- W2398538703 cites W2094595413 @default.
- W2398538703 cites W2099031921 @default.
- W2398538703 cites W2109877347 @default.
- W2398538703 cites W2113523455 @default.
- W2398538703 cites W2115647596 @default.
- W2398538703 cites W2136245016 @default.
- W2398538703 cites W2137132470 @default.
- W2398538703 cites W2139306838 @default.
- W2398538703 cites W2141256350 @default.
- W2398538703 cites W4210407906 @default.
- W2398538703 doi "https://doi.org/10.1039/9781849739689-00180" @default.
- W2398538703 hasPublicationYear "2013" @default.
- W2398538703 type Work @default.
- W2398538703 sameAs 2398538703 @default.
- W2398538703 citedByCount "0" @default.
- W2398538703 crossrefType "book-chapter" @default.
- W2398538703 hasAuthorship W2398538703A5067130524 @default.
- W2398538703 hasConcept C104317684 @default.
- W2398538703 hasConcept C142724271 @default.
- W2398538703 hasConcept C150903083 @default.
- W2398538703 hasConcept C185592680 @default.
- W2398538703 hasConcept C205260736 @default.
- W2398538703 hasConcept C207001950 @default.
- W2398538703 hasConcept C2775932338 @default.
- W2398538703 hasConcept C2776256026 @default.
- W2398538703 hasConcept C2777560012 @default.
- W2398538703 hasConcept C2780394083 @default.
- W2398538703 hasConcept C502942594 @default.
- W2398538703 hasConcept C55493867 @default.
- W2398538703 hasConcept C71924100 @default.
- W2398538703 hasConcept C86803240 @default.
- W2398538703 hasConceptScore W2398538703C104317684 @default.
- W2398538703 hasConceptScore W2398538703C142724271 @default.
- W2398538703 hasConceptScore W2398538703C150903083 @default.
- W2398538703 hasConceptScore W2398538703C185592680 @default.
- W2398538703 hasConceptScore W2398538703C205260736 @default.
- W2398538703 hasConceptScore W2398538703C207001950 @default.
- W2398538703 hasConceptScore W2398538703C2775932338 @default.
- W2398538703 hasConceptScore W2398538703C2776256026 @default.
- W2398538703 hasConceptScore W2398538703C2777560012 @default.
- W2398538703 hasConceptScore W2398538703C2780394083 @default.
- W2398538703 hasConceptScore W2398538703C502942594 @default.
- W2398538703 hasConceptScore W2398538703C55493867 @default.
- W2398538703 hasConceptScore W2398538703C71924100 @default.
- W2398538703 hasConceptScore W2398538703C86803240 @default.
- W2398538703 hasLocation W23985387031 @default.
- W2398538703 hasOpenAccess W2398538703 @default.
- W2398538703 hasPrimaryLocation W23985387031 @default.
- W2398538703 hasRelatedWork W1967103478 @default.
- W2398538703 hasRelatedWork W2032912323 @default.
- W2398538703 hasRelatedWork W2148097028 @default.
- W2398538703 hasRelatedWork W2349030099 @default.
- W2398538703 hasRelatedWork W2359165709 @default.
- W2398538703 hasRelatedWork W2372561159 @default.
- W2398538703 hasRelatedWork W2375344515 @default.
- W2398538703 hasRelatedWork W2380382254 @default.
- W2398538703 hasRelatedWork W2390152934 @default.
- W2398538703 hasRelatedWork W2908335280 @default.
- W2398538703 isParatext "false" @default.
- W2398538703 isRetracted "false" @default.
- W2398538703 magId "2398538703" @default.
- W2398538703 workType "book-chapter" @default.