Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398630335> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2398630335 endingPage "8" @default.
- W2398630335 startingPage "185" @default.
- W2398630335 abstract "In the gallbladders of germ-free guinea-pigs, biliary sludge appeared in all 4 two-week-old animals and concrete gallstones appeared at the age of four weeks in all of 9 animals. Qualitative analysis of the gallstones revealed positive bilirubin reactions. Infrared spectrum indicated that the gallstones contained calcium bilirubinate, phosphate and protein. These characteristics are similar to those of gallstones induced in guinea-pigs by partial ligation of the common bile duct without infection. There was no stone in the control group. At the age of four weeks, the indirect reactive bilirubin (IB, represent UCB) concentration in gallbladder bile from germ-free guinea-pigs (0.84 +/- 0.16 mg/dl, n = 8) was higher than that of control animals (0.28 +/- 0.12 mg/dl, n = 9, P less than 0.05); as was the ratio of ionized calcium to total calcium (0.28 +/- 0.04, n = 8, vs 0.16 0.03, n = 7, P less than 0.05). Thus, the characteristics of gallbladder bile in germ-free guinea-pigs (which are susceptible to pigment stones) are consistent with those of bile from human beings with pigment gallstones. Since the presence of intestinal flora is essential for the normal metabolism of bile salts and the regulation of their enterohepatic circulation, the germ-free state of the guinea-pigs must have been responsible for the gallstone formation in these animals. Our experiments have shown that germ-free guinea-pigs provide a useful animal model for investigating the role of intestinal flora and bile salts metabolism in pigment gallstone formation. The gallstone incidence in this animal model is high, and the experimental period is short." @default.
- W2398630335 created "2016-06-24" @default.
- W2398630335 creator A5009142066 @default.
- W2398630335 date "1991-06-01" @default.
- W2398630335 modified "2023-09-23" @default.
- W2398630335 title "[The germ-free guinea-pig as an animal model of pigment gallstone]." @default.
- W2398630335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1831723" @default.
- W2398630335 hasPublicationYear "1991" @default.
- W2398630335 type Work @default.
- W2398630335 sameAs 2398630335 @default.
- W2398630335 citedByCount "0" @default.
- W2398630335 crossrefType "journal-article" @default.
- W2398630335 hasAuthorship W2398630335A5009142066 @default.
- W2398630335 hasConcept C126322002 @default.
- W2398630335 hasConcept C134018914 @default.
- W2398630335 hasConcept C2776884468 @default.
- W2398630335 hasConcept C2777148285 @default.
- W2398630335 hasConcept C2777513400 @default.
- W2398630335 hasConcept C2778620825 @default.
- W2398630335 hasConcept C2778815084 @default.
- W2398630335 hasConcept C2779388726 @default.
- W2398630335 hasConcept C2779399885 @default.
- W2398630335 hasConcept C2909467636 @default.
- W2398630335 hasConcept C519063684 @default.
- W2398630335 hasConcept C71924100 @default.
- W2398630335 hasConcept C86803240 @default.
- W2398630335 hasConcept C90924648 @default.
- W2398630335 hasConceptScore W2398630335C126322002 @default.
- W2398630335 hasConceptScore W2398630335C134018914 @default.
- W2398630335 hasConceptScore W2398630335C2776884468 @default.
- W2398630335 hasConceptScore W2398630335C2777148285 @default.
- W2398630335 hasConceptScore W2398630335C2777513400 @default.
- W2398630335 hasConceptScore W2398630335C2778620825 @default.
- W2398630335 hasConceptScore W2398630335C2778815084 @default.
- W2398630335 hasConceptScore W2398630335C2779388726 @default.
- W2398630335 hasConceptScore W2398630335C2779399885 @default.
- W2398630335 hasConceptScore W2398630335C2909467636 @default.
- W2398630335 hasConceptScore W2398630335C519063684 @default.
- W2398630335 hasConceptScore W2398630335C71924100 @default.
- W2398630335 hasConceptScore W2398630335C86803240 @default.
- W2398630335 hasConceptScore W2398630335C90924648 @default.
- W2398630335 hasIssue "3" @default.
- W2398630335 hasLocation W23986303351 @default.
- W2398630335 hasOpenAccess W2398630335 @default.
- W2398630335 hasPrimaryLocation W23986303351 @default.
- W2398630335 hasRelatedWork W118372930 @default.
- W2398630335 hasRelatedWork W130415026 @default.
- W2398630335 hasRelatedWork W1895116506 @default.
- W2398630335 hasRelatedWork W1999048394 @default.
- W2398630335 hasRelatedWork W2062648442 @default.
- W2398630335 hasRelatedWork W2376322896 @default.
- W2398630335 hasRelatedWork W2398630335 @default.
- W2398630335 hasRelatedWork W2411035525 @default.
- W2398630335 hasRelatedWork W26879888 @default.
- W2398630335 hasRelatedWork W3030157866 @default.
- W2398630335 hasVolume "13" @default.
- W2398630335 isParatext "false" @default.
- W2398630335 isRetracted "false" @default.
- W2398630335 magId "2398630335" @default.
- W2398630335 workType "article" @default.